Perspectives for new anti-tuberculous vaccines in the post-genomic era.
Keywords:
tuberculosis, vaccines, Mycobacterium tuberculosis
Abstract
Vaccination with attenuated Mycobacterium bovis BCG has been used as the routine procedure to immunize against tuberculosis. Since the efficacy of BCG vaccination is very controversial, the search for new immunoprophylatic tools against tuberculosis is an area of intense interest. Knowledge of the complete sequence of Mycobacterium tuberculosis (Mtb) H37Rv genome and the application of new immunological, biochemical and genetic technologies has led to a detailed understanding of the transcriptome and proteome of this bacterium. Approximately one-third of the human population is infected with Mtb; however, the bacillus is only detected once the symptoms appear and therefore most of the recent efforts have been devoted to the development of a post-infection vaccine. In theory, this vaccine (1) will give rise to an increase in the long-lasting specific immunity against Mtb, (2) will not have significant adverse effects, and (3) will be affordable for the people in third world countries. The main strategies that have been developed include the subunit vaccines, either as a mixture of relevant immunogenic proteins or DNA constructs, recombinant strains of Mycobacterium bovis BCG and Mtb, designed to secrete immunogenic proteins or with attenuated virulence, respectively, and DNA-based vaccines. The subunit vaccines are delivered either as mixtures of immunogenic proteins and adjuvants, or as naked DNA or by viral vectors in order to induce a potent Th1 response. Most of these vaccines have been tested in several kinds of animal models, but they do not fully reproduce the human pathology. However, the results obtained so far are very encouraging and have led to the development of phase I trials in humans.Downloads
Download data is not yet available.
How to Cite
1.
García LF, Barrera LF. Perspectives for new anti-tuberculous vaccines in the post-genomic era. biomedica [Internet]. 2004 Jun. 1 [cited 2024 Jul. 12];24(Sup1):228-38. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1320
Some similar items:
- Juan Gabriel Bueno-Sánchez, Jairo René Martínez-Morales, Elena E. Stashenko, Wellman Ribón, Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia , Biomedica: Vol. 29 No. 1 (2009)
- María Consuelo Garzón, Dailyn Yorledy Angée, Claudia Llerena, Dora Leticia Orjuela, Jorge Ernesto Victoria, Surveillance of Mycobacterium tuberculosis resistance to antituberculosis drugs , Biomedica: Vol. 28 No. 3 (2008)
- Diana Hoyos , Rossi Meza, Liliana Forero , César Moreira, Beatriz E. Ferro, Robinson Pacheco , Treatment for RR/MDR tuberculosis: a comparative analysis of programmatic outcome indicators between Buenaventura and other municipalities of Valle del Cauca-Colombia , Biomedica: Vol. 44 No. 3 (2024): Publicación anticipada, septiembre
- Leandro Galvis, Ángel Y. Sánchez, Leonardo F. Jurado, Martha I. Murcia, Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia , Biomedica: Vol. 38 No. 1 (2018)
- Diego Chaves, Andrea Sandoval, Luis Rodríguez, Juan C. García, Silvia Restrepo, María Mercedes Zambrano, Comparative analysis of six Mycobacterium tuberculosis complex genomes , Biomedica: Vol. 30 No. 1 (2010)
- Leonardo F. Jurado, Martha I. Murcia, Patricia Hidalgo, John E. Leguizamón, Lorena R. González, Phenotypic and genotypic diagnosis of bone and miliary tuberculosis in an HIV+ patient in Bogotá, Colombia , Biomedica: Vol. 35 No. 1 (2015)
- Lorena González, Ricardo Sánchez, Martha Isabel Murcia, The usefulness of the nitrate reductase assay for detecting drug-resistant Mycobacterium tuberculosis , Biomedica: Vol. 34 (2014): Abril, Suplemento 1, Resistencia bacteriana
- Dihadenys Lemus, Miguel Echemendía, Raúl Díaz, Alina Llop, María Josefa Llanes, Surveillance of antituberculosis-drug resistance in Cuba, 2010-2011 , Biomedica: Vol. 34 (2014): Abril, Suplemento 1, Resistencia bacteriana
- Diana Castaño, Mauricio Rojas, Alterations in recruitment and activation of Rab proteins during mycobacterial infection , Biomedica: Vol. 30 No. 2 (2010)
- Sonia Isabel Cuervo, Diego Andrés Bonilla, Martha Isabel Murcia, Johana Hernández, Julio César Gómez, Tuberculosis of the breast , Biomedica: Vol. 33 No. 1 (2013)
Published
2004-06-01
Section
Topic review
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |