Evaluación de la infestación por Strongyloides stercoralis en pacientes con HTLV-1

Nilo Manoel Pereira Vieira Barreto , Marina Morena Brito Farias , Cíntia de Lima Oliveira, Weslei Almeida Costa Araujo , Maria Fernanda Rios Grassi , Joelma Nascimento de Souza , Beatriz Soares Jacobina , Márcia Cristina Aquino Teixeira, Bernardo Galvão-Castro, Neci Matos Soares, .

Palabras clave: Strongyloides stercoralis, estrongiloidiasis, virus linfotrópico T de tipo 1 humano, coinfección, helmintos

Resumen

Introducción. Los individuos infectados por el virus linfotrópico T humano tipo 1 (HTLV-1) pueden presentar formas graves y diseminadas de infestación por Strongyloides stercoralis con poca mejoría terapéutica.
Objetivo. Investigar la infestación por S. stercoralis y la seroprevalencia de IgG anti-S. stercoralis en individuos infectados por HTLV-1 atendidos en el Centro de Referencia para HTLV-1 (CHTLV), en Salvador, Bahía, Brasil.
Materiales y métodos. Se hizo un estudio transversal con 178 individuos infectados por HTLV-1 atendidos en el centro especializado de HTLV entre enero de 2014 y diciembre de 2018. El diagnóstico parasitológico de S. stercoralis se hizo mediante los métodos de Hoffman, Pons y Janer, cultivo en placa de agar y Baermann-Morais. Para la detección de IgG anti-S. stercoralis, se utilizó una prueba casera de inmunoabsorción ligada a enzimas (ELISA). La infección por HTLV-1 se diagnosticó usando un ELISA comercial y se confirmó mediante Western blot.
Resultados. La frecuencia de infestación por S. stercoralis fue del 3,4 % (6/178). Además, los individuos infestados por S. stercoralis provenientes de la zona rural (50,0 %; 3/6) también mostraron hiperinfestación por S. stercoralis (>3.000 larvas/gramo de heces). La frecuencia de anticuerpos IgG anti-S. stercoralis fue del 20,8 % (37/178).
Conclusiones. Las personas infectadas por HTLV-1 que viven en condiciones sanitarias precarias son más propensas a desarrollar formas graves de infestación por S. stercoralis. Teniendo en cuenta la gran vulnerabilidad y el resultado desfavorable de la infección en estos individuos, se debe considerar el diagnóstico serológico de S. stercoralis para administrar el tratamiento.

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  • Nilo Manoel Pereira Vieira Barreto Instituto de Ciências da Saúde, Programa de Pós-graduação em Processos Interativos dos Órgãos e Sistemas, Universidade Federal da Bahia, Bahia, Brasil
  • Marina Morena Brito Farias Instituto de Ciências da Saúde, Programa de Pós-graduação em Processos Interativos dos Órgãos e Sistemas, Universidade Federal da Bahia, Bahia, Brasil
  • Cíntia de Lima Oliveira Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Weslei Almeida Costa Araujo Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Maria Fernanda Rios Grassi Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Bahia, Brasil
  • Joelma Nascimento de Souza Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Beatriz Soares Jacobina Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil
  • Márcia Cristina Aquino Teixeira Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Bernardo Galvão-Castro Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil
  • Neci Matos Soares Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil

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Cómo citar
1.
Pereira Vieira Barreto NM, Brito Farias MM, Oliveira C de L, Almeida Costa Araujo W, Rios Grassi MF, Nascimento de Souza J, et al. Evaluación de la infestación por Strongyloides stercoralis en pacientes con HTLV-1. biomedica [Internet]. 1 de marzo de 2022 [citado 28 de marzo de 2024];42(1):31-40. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/5888
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2022-03-01
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