Efectos del ejercicio físico sobre la cognición en mujeres mayores tratadas con lovastatina

Edgardo Molina-Sotomayor, Rocío Arreguín-Moreno, Fernando Rodríguez-Rodríguez, Francisco Pradas, Juan Antonio León, José Antonio González-Jurado, .

Palabras clave: ejercicio, cognición, dislipidemias, inhibidores de hidroximetilglutaril-CoA reductasa, salud mental, envejecimiento

Resumen

Introducción. El deterioro cognitivo tiene una gran incidencia en el adulto mayor.
Objetivo. El principal objetivo de este estudio fue analizar los efectos sobre la cognición y la concentración de lípidos de un programa de caminatas en mujeres mayores de 60 años tratadas con lovastatina.
Materiales y métodos. Las participantes se distribuyeron en dos grupos: uno con ejercicio (EG, n=45) sometido a entrenamiento aeróbico y otro inactivo o sedentario (SG, n=22). El estado cognitivo se evaluó mediante la versión en español del Mini-Mental Test. Los niveles de lipoproteínas se midieron con una prueba de perfil lipídico y la aptitud cardiorrespiratoria se valoró con la prueba de caminata de 6 minutos (Six-Minute Walking Test, 6MWT).
Resultados. El grupo con ejercicio mostró una mejora significativa (p<0,05) de la aptitud cardiorrespiratoria y de las concentraciones de colesterol HDL. Además, en la prueba de cognición se observó un efecto de gran tamaño en la orientación espacial, en la atención y en el cálculo. La reducción del colesterol LDL no fue significativa.
Conclusión. Un programa de entrenamiento progresivo y supervisado para mujeres mayores tratadas con lovastatina, podría mejorar la actividad cerebral relacionada con el colesterol HDL, lo cual podría retrasar el deterioro cognitivo.

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  • Edgardo Molina-Sotomayor Departamento de Educación Física, Universidad Metropolitana de Ciencias de la Educación, Santiago de Chile, Chile
  • Rocío Arreguín-Moreno Departamento de Psicología y Ciencias de la Comunicación, Universidad de Sonora, Hermosillo, México
  • Fernando Rodríguez-Rodríguez Grupo IRyS, Escuela de Educación Física, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile
  • Francisco Pradas Departamento de Expresión Musical, Plástica y Corporal, Universidad de Zaragoza, Zaragoza, España
  • Juan Antonio León Departamento de Expresión Musical, Plástica y Corporal, Universidad de Zaragoza, Zaragoza, España
  • José Antonio González-Jurado Facultad de Ciencias del Deporte, Universidad Pablo de Olavide, Sevilla, España http://orcid.org/0000-0003-2222-6089

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Cómo citar
Molina-Sotomayor, E., Arreguín-Moreno, R., Rodríguez-Rodríguez, F., Pradas, F., León, J. A., & González-Jurado, J. A. (2018). Efectos del ejercicio físico sobre la cognición en mujeres mayores tratadas con lovastatina. Biomédica, 38(4), 496-506. https://doi.org/10.7705/biomedica.v38i4.4262

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2018-12-01
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