Asociación del polimorfismo Apal del gen receptor de vitamina D con la obesidad en una población iraní

Farzad Rashidi , Maryam Ostadsharif, .

Palabras clave: obesidad/genética, vitamina D, polimorfismo genético, índice de masa corporal, Irán

Resumen

Introducción. La determinación de los factores de riesgo de la obesidad en la población iraní como problema de salud de la comunidad es crucial dada su complejidad. El gen receptor de la vitamina D (VDR) se ha mencionado como posible causante de dicha enfermedad.
Objetivo. El objetivo del estudio fue investigar la asociación de los polimorfismos Apal, Bsml y Taql, con el gen VDR y la obesidad en una población iraní.
Materiales y métodos. Se analizaron genotipos de 348 individuos obesos (BMI≥30 kg/m²) y 320 no obesos (BMI: 18,5-24,9 kg/m²) mediante reacción en cadena de la polimerasa y polimorfismos de longitud de fragmentos de restricción (PCR-RFLP). Para medir los niveles de glucemia en ayunas, tiroglobulina (TG), colesterol total, colesterol HDL y colesterol LDL, se utilizó un analizador bioquímico automático.
Resultados. Los índices de masa corporal, glucemia en ayunas y TG fueron significantemente más elevados en el grupo de los obesos que en el de control. En los individuos obesos, la incidencia del genotipo AA fue de 47,1 % y la del genotipo combinado Aa+aaa fue de 52,9 %, en tanto que en el grupo de control estas cifras fueron, respectivamente, de 30 y 70 % (p=0,024; IC95% 1,100-3,933; la razón de probabilidades (OR) fue de 2,08. La frecuencia de los alelos “A” y “a” para el polimorfismo Apal en ambos grupos fue estadísticamente significativa (alelo A Vs. A; p=0,017). No se observó ninguna relación significativa entre los genotipos Taql y los alelos en los sujetos obesos y, tampoco, en los controles.
Conclusión. El polimorfismo Apal del gen VDR (rs 7975232C/A) sería un factor de riesgo para la obesidad. El alelo y el genotipo AA en dicho polimorfismo se asociaron con los fenotipos de obesidad.

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  • Farzad Rashidi Departamento de Immunología, Escuela de Medicina, Universidad Complutense, Madrid, España; Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran https://orcid.org/0000-0002-4930-5636
  • Maryam Ostadsharif Department of Medical Basic Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran; Department of Medical Biotechnology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran https://orcid.org/0000-0003-0824-2904

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Cómo citar
1.
Rashidi F, Ostadsharif M. Asociación del polimorfismo Apal del gen receptor de vitamina D con la obesidad en una población iraní. biomedica [Internet]. 15 de diciembre de 2021 [citado 7 de diciembre de 2022];41(4):651-9. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/5898
Publicado
2021-12-15
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Artículos originales