Potentially inappropriate medication on communitydwelling older adults: Longitudinal analysis using the International Mobility in Aging Study

Edison Pineda, Alejandra Fernández, Carmen Lucía Curcio, Juliana Fernandes de Souza, Afshin Vafaei, José Fernando Gómez, .

Keywords: Potentially inappropriate medication list, polypharmacy, aged, Independent Living, prevalence, longitudinal studies

Abstract

Introduction. Medications are a fundamental part of the treatment of multiple pathologies. However, despite their benefits, some are considered potentially inappropriate medications for older people given their safety profile. Epidemiological data differences related to potentially inappropriate medications make it difficult to determine their effects on elderly people.
Objective. To estimate the prevalence and types of potentially inappropriate medications using the 2019 Beers Criteria® in a cohort of adults older than 65 years.
Materials and methods. We performed an observational, multicenter, retrospective, longitudinal study of a four-year follow-up of potentially inappropriate medications in community-dwelling older adults.
Results. We followed 820 participants from five cities for four years (2012-2016) and evaluated them in three different moments (m1 = 2012, m2 = 2014, and m3 = 2016). The average age was 69.07 years, and 50.9% were women. The potentially inappropriate medication prevalence in the participants was 40.24%. The potentially inappropriate medications’ mean among the studied subjects in the first moment was 1.65 (SD = 0.963), in the second was 1.73 (SD = 1.032), and in the third was 1.62 (SD = 0.915). There were no statistical differences between measurements (Friedman test, value = 0.204). The most frequent potentially inappropriate medications categories were gastrointestinal (39.4%), analgesics (18.8%), delirium-related drugs (15.4%), benzodiazepines (15.2%), and cardiovascular (14.2%).
Conclusions. About half of the population of the community-dwelling older adults had prescriptions of potentially inappropriate medications in a sustained manner and without significant variability over time. Mainly potentially inappropriate medications were gastrointestinal and cardiovascular drugs, analgesics, delirium-related drugs, and benzodiazepines.

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  • Edison Pineda Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia; Grupo de Investigación en Gerontología y Geriatría, Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia https://orcid.org/0000-0001-7442-2247
  • Alejandra Fernández Hospital Alma Mater de Antioquia, Medellín, Colombia https://orcid.org/0000-0002-6014-2292
  • Carmen Lucía Curcio Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia; Grupo de Investigación en Gerontología y Geriatría, Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia https://orcid.org/0000-0002-8063-2301
  • Juliana Fernandes de Souza Laboratório de Fisioterapia e Saúde Coletiva, Departamento de Fisioterapia da Universidade Federal de Pernambuco, Recife, Brasil https://orcid.org/0000-0002-7509-8853
  • Afshin Vafaei School of Health Studies, Western University, Kingston, ON, Canada https://orcid.org/0000-0002-3605-409X
  • José Fernando Gómez Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia; Grupo de Investigación en Gerontología y Geriatría, Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia https://orcid.org/0000-0003-4360-8174

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How to Cite
1.
Pineda E, Fernández A, Curcio CL, Fernandes de Souza J, Vafaei A, Gómez JF. Potentially inappropriate medication on communitydwelling older adults: Longitudinal analysis using the International Mobility in Aging Study. biomedica [Internet]. 2024 May 30 [cited 2024 Jul. 3];44(2):207-16. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/6992

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Published
2024-05-30
Section
Original articles

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