Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato

Jaime Carmona-Fonseca, Eliana Arango, Silvia Blair, .

Palabras clave: malaria/ terapia, malaria falciparum, Plasmodium falciparum, antipalúdicos, amodiaquina, sulfadoxina, pirimetamina, Artemisia annua

Resumen

Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América.
Objetivo. Describir relaciones de la gametocitemia falciparum con el tratamiento con amodiaquina-sulfadoxina-pirimetamina, artesunato-sulfadoxina-pirimetamina o amodiaquina-artesunato.
Materiales y métodos. Se usó un diseño experimental, aleatorio, no balanceado, no ciego. El seguimiento fue de 21 a 28 días. La eficacia terapéutica se clasificó según el protocolo de la Organización Mundial de la Salud, 1998.
Resultados.
Se evaluaron 241 pacientes en Turbo, El Bagre y Zaragoza (Antioquia, Colombia). El esquema de amodiaquina-sulfadoxina-pirimetamina tuvo igual eficacia que el de artesunato-sulfadoxina-pirimetamina y amodiaquina-artesunato para controlar las fallas terapéuticas el día 21. Hubo cuatro fallas (1,66%). El esquema de amodiaquina-sulfadoxina-pirimetamina fue menos eficaz que los tratamientos con artesunato para reducir la presencia de gametocitos. Al séptimo día, ninguno de los tres tratamientos había eliminado totalmente los gametocitos. La mayoría (56%) de nuestros pacientes no tenía gametocitos antes del tratamiento y nunca los desarrolló. El tiempo para eliminar los gametocitos que se tenían al iniciar el tratamiento no fue mayor cuando la gametocitemia inicial era mayor.
Conclusión.Los tres tratamientos fueron iguales en cuanto a eficacia terapéutica e incapacidad de eliminar los gametocitos en siete días.

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  • Jaime Carmona-Fonseca Grupo Salud y Comunidad, Universidad de Antioquia, Medellín, Colombia
  • Eliana Arango Grupo Malaria, Universidad de Antioquia, Medellín, Colombia
  • Silvia Blair Grupo Malaria, Universidad de Antioquia, Medellín, Colombia

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Cómo citar
Carmona-Fonseca, J., Arango, E., & Blair, S. (1). Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato. Biomédica, 28(2), 195-212. https://doi.org/10.7705/biomedica.v28i2.91
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