Evaluation of different peptides in hepatitis C virus structural region

Abstract

Elisa tests are widely used for the diagnosis of hepatitis C virus infection because of their sensitivity and specificity. Most of the Elisas are based on the use of synthetic peptides The structural region of the virus is one of the most preserved regions and it shows high immunogenicity. Seven highly inmunogenic peptides from hiqhly inmunogenic areas in hepatitis C virus structural region were synthesized. Those peptides represent the structural region of the hepatitis C virus. Results of synthesized peptides were tested and compared. Positive (n=72) and negative (n=42) samples were employed. Reactivity was high in peptides closest to the N-terminus region and it decreased toward the C-terminus region. The results coincide with other authors' results.