Role of the cytokine-3 signaling suppressor protein (SOCS 3) in growth hormone resistance induced by malnutrition.
Keywords:
growth hormone, suppressor of cytokine signaling proteins, malnutrition, hormones
Abstract
Nutrition is an important regulator of growth hormone (GH) action. Nutritional deprivation causes a GH resistance involving post-receptor alterations in the signaling pathway, but the responsible mechanisms remain unknown. Herein, suppressors of cytokine signaling proteins (SOCS) were investigated as potential agents in GH-resistance induced by malnutrition which inhibits activation of Janus kinase 2/signal transductor and activator of transcription 5 (JAK2/STAT5) pathway. Growth hormone receptor (GHR), IGF-I and SOCS3 mRNA expression was measured in the liver of rats fed with a low protein diet and with GH stimulation. Protein diet restriction significantly diminished GHR mRNA and receptor binding sites (p < 0.05), but caused a highly increased SOCS3 gene expression. In diet-restricted rats, GH administration increased GHR and IGF-I mRNA; however, GHR reached basal levels observed in animals feeding with a high protein diet. The malnourished group increased SOCS3 gene transcription in response to GH administration. These results suggested that a reduced hepatic sensitivity to GH was associated with SOCS3 over-expression. In addition, ubiquitous distribution of SOCS3 and CIS suggests a role for SOCS proteins as tissue specific modulators of cytokine sensitivity.Downloads
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How to Cite
1.
Umaña A, Carrasco S, Sánchez M. Role of the cytokine-3 signaling suppressor protein (SOCS 3) in growth hormone resistance induced by malnutrition. biomedica [Internet]. 2003 Sep. 1 [cited 2024 May 19];23(3):301-8. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1224
Published
2003-09-01
Issue
Section
Original articles
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