Amiloidosis sistémica adquirida. Estudio de 6 casos y revisión bibliográfica

Abstract

Acquired Systemic Amyloidosis is a progressive disease with clinical characteristics detennined by the extracellular distribution of the fibrillosis beta of the amyloid in any organic tissue. In our country, we do not have many reports about this disease. We report these 6 cases because of the diversity of clinical situations in which they occured. In 3 patients, the disease was associated with dyscracia of plasmatic cells without monoclonal component. The other 3 patients showed multiple myeloma as basic disease. One of them presented with the P.O.E.M.S. syndrome. In patients with multiple myeloma, the use of immuno- supressive drugs improves the A. S.A. But, if there is dyscrasia of plasmatic cells with monoclonal component the improvement with immunosupressive drugs is poor and the risks are very high. For this reason, colchicin is the only drug recommended. Improvement of A. S. A. with colchicin after 12 months of continuous treatment is clear, but since our number of cases is small, we cannot bring out any definitive conclussions.