Algunos aspectos inmunológicos e inmunogenéticos de la infección con el virus de la hepatitis B (VHB) y de la aplicación de vacunas antihepatitis B

Abstract

The purpose of this review is to present results of studies realized on Hepatitis B cell mediated inununology as well as on the immune response to Hepatitis B vaccine. Since 1980, several studies on this subjet has heen published, some of them dealt with antibody production, ceii pmliferation under antigen and mitogens stimulation, defects on T cell, B-T ceiis and macmphages; some of these studies, are contradictories. Using mouoclonal antibodies against CD8, binded to polystirene plate we were able to separate CD4 sub-populations and perform experiments trying to explain the mon-response to specif antigen, which seems to be dueto a failure in antigen presentation.