Hepatitis B: Inmunogenicidad de la vacuna recombinante cubana anti-hbv en trabajadores de la salud vacunados sin seroprotección

Abstract

We measured ant-HBs to 153 health care workers in the Children Hospital Lorencita Villegas de Santos in Bogota who had receive Hepatitis B vaccine in the last 4 years. 124 had receive three doses (6 with booster), 18 two doses and 11 only one. They hadn't any positive titles in 25%, 33% and 73% respectively. Their average age was 40 years old. Then we gave 32 of the worker who has negative titles one 20 mgms dose of the Cuban recombinant vaccine and we measured blind titles before and 15 days after with ELISA quantitative method. 81% went into seroconversion (> O UYL), 75% seroprotection (> 10 IUIL) and 56% had levels over 100 UVL. This results are hilly significant and raises a possibility for health care workers who are "poor antibody responders" with other types of vaccines or even other population with the same problem.