Estudio de inmunogenicidad para dos vacunas recombinantes contra hepatitis B

Abstract

This study compares the immunogenicity (seroconversion, seroprotection and hiperesponse) produced by two hepatitis B recombinant vaccines (Engerix- B Belge and Cuban). For this purpose two sketches were used (012 and 016 months). The anti-HBs quantification was performed by using Abbott and Organon methods in order to compare its results. In the study 257 volunteers were distributed in four groups to the hapazard (two vaccines and two sketches). Results: the Abbott and Organon methods did not show any statistically significant difference. The Cuban vaccine shows greater immunogenous response for two doses and 012 sketch. There are no differences between sketch 012 and 016 with the Cuban vaccine. The scheme 016 did not show statistically significant difference for the Engerix-B Belge vaccine. The last mentioned vaccine showed to be better with the 016 scheme.