Anticuerpos anti-Ro y anti-La. Caracterización molecular, correlación clínica e inmunogenética

Abstract

The anti-Ro and Anti-La antibodies have been studied since 25 years ago, but theirs molecular structure, clinical association and genetics relation have aquiered special relevance only in the last past seven years. These antibodies have special interest in the physiopathology of SLE, and in the Sjogren syndrome. In the so called neonatal lupus these antibodies seems to playa direct role in its physiopathology, while in others situations such as vasculitis and nephiritis the tissue damage could be due to the inmune complexes deposition in the vascular structures.