Determinación de la betalactamasa en cepas de Neisseria gonorrhoeae

Abstract

The appearance of strains of N. gonorrhoeae resistant to different antibiotics, which could be caused by plasmids or by mutations, require constant surveillance so as to revise the schemes of treatment. In our country the existent studies to determine the problem of strains of N. gonorrhoeae resistent to penicilin have been scarce therefore it was decided to determine the presence of beta lactamase and antimicrobe susceptibility from isolates of this pathogen obtained from different health services around the country. From 89 strains studied 46 (52%) were producers of beta lactamase; 11% of these presented resistance to spectinomycin and 96% to tetracycline. In the strains which did not produce beta lactamase, 61% were resistant to tetracycline and 2% to penicilin: additionally 98% of the NPBL strains presented a moderate sensitivity to penicilin. All the PBL and NPBL strains were sensitive to ceftriaxone. This data confirms the circulation of PBL strains of N. gonorrhoeae throughout different regions of the country and supports the recommendation to maintain surveillance, permitting the determination of the real frequency of these strains in our country.