Eaton-Lambert myasthenic syndrome
Keywords:
Myasthenia gravis, thymoma, Lambert-Eaton
Abstract
A 70-year-old woman without unusual medical history was admitted at a local hospital with complaints of fatigue, muscle weakness in the extremities and double vision. On examination, bilateral ptosis (figure 1), facial paresis, proximal-dominant limb muscle atrophy and generalized arreflexia were observed. On the basis of tentative diagnosis of myasthenia gravis, an electrodiagnostic study was conducted. It demonstrated abnormally low-amplitude muscular action potentials, but with a large increase after repetitive stimulation at 50 Hz. These responses are characteristic of the Eaton-Lambert myasthenic syndrome. A screening for malignant diseases was performed and chest radiography showed an anterior mediastinal mass (figure 2). The patient was scheduled for thymectomy, and subsequent histopathology of the thymus gland revealed a type B1 thymoma with areas reminiscent of a normal thymic cortex and medulla (figure 3). After the thymectomy most of the myasthenic symptoms were no longer in evidence. Generally, the Eaton-Lambert myasthenic syndrome is associated with small cell lung carcinoma, but this was an illustrative case associated with thymoma.Downloads
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How to Cite
1.
Cataño JC. Eaton-Lambert myasthenic syndrome. biomedica [Internet]. 2010 Sep. 30 [cited 2024 May 16];30(3):319-20. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/262
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Published
2010-09-30
Issue
Section
Imágenes en biomedicina
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