Small cell lung cancer associated with multiple paraneoplastic syndromes
Abstract
We report the case of a patient presenting with multiple severe electrolyte disturbances who was subsequently found to have small cell lung cancer. Upon further evaluation, she demonstrated three distinct paraneoplastic processes, including the syndrome of inappropriate antidiuretic hormone, Fanconi syndrome, and an inappropriate elevation in fibroblast growth factor-23 (FGF23). The patient underwent one round of chemotherapy, but she was found to have progressive disease. After 36 days of hospitalization, the patient made the decision to enter hospice care and later she expired.
Downloads
References
Orr LE. Fanconi syndrome and oat cell carcinoma of the lung. West J Med. 1980;133:250-1.
Breton JL, Dalphin JC, Depierre A, Wendling D. Fanconi syndrome and small cell anaplastic bronchial cancer. Ann Med Interne (Paris). 1987;138:554.
Tantisattamo E, Ng RC. Dual paraneoplastic syndromes: Small cell lung carcinoma-related oncogenic osteomalacia, and syndrome of inappropriate antidiuretic hormone secretion: Report of a case and review of the literature. Hawaii Med J. 2011;70:139-43.
Smith ER, McMahon LP, Holt SG. Fibroblast growth factor 23. Ann Clin Biochem. 2014;51:203-27. http://dx.doi.org/10.1177/0004563213510708
Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, et al. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med. 2003;348:1656-63. http://dx.doi.org/10.1056/NEJMoa020881
Dadoniene J, Miglinas M, Miltiniene D, Vajauskas D, Seinin D, Butenas P, et al. Tumour-induced osteomalacia: A literature review and a case report. World J Surg Oncol. 2016;14:4. http://dx.doi.org/10.1186/s12957-015-0763-7
Higley M, Beckett B, Schmahmann S, Dacey E, Foss E. Locally aggressive and multifocal phosphaturic mesenchymal tumors: Two unusual cases of tumor-induced osteomalacia. Skeletal Radiol. 2015;44:1825-31. http://dx.doi.org/10.1007/s00256-015-2246-x.
Some similar items:
- Antistio Aníbal Alviz, Rubén Darío Salas, Luis Alberto Franco, Acute diuretic effect of ethanolic and aqueous extracts of Ceratopteris pteridoides (Hook) in normal rats , Biomedica: Vol. 33 No. 1 (2013)
- Gerzaín Rodríguez, Elga Vargas, Claudia Abaúnza, Sergio Cáceres, Necrolytic migratory erythema and pancreatic glucagonoma , Biomedica: Vol. 36 No. 2 (2016)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |