Cytomegalovirus seroprevalence in organ donors and kidney transplant recipients, Colombia, 2010-2014
Abstract
Introduction: Cytomegalovirus infections have gained high importance for individuals that have received organ transplants given the clinical implications this may have in immunocompromised patients. Objective: To describe the seroprevalence of cytomegalovirus in organ donors and recipients of kidney transplants nationwide from the six regions established by the Red Nacional de Donación y Trasplante. Materials and methods: We conducted a descriptive retrospective study that included 1,813 organ donors and 3,313 recipients of kidney transplants, and we calculated IgM and IgG seroprevalence for cytomegalovirus. IgG prevalence was stratified according to sex, age group, and region, and the results were analyzed in each donor-recipient pair and classified according to the risk. Statistical packages IBM SPSS®, Statistics 22, and Epi Info 7 were utilized. Results: IgG prevalence for cytomegalivirus was 86.8% in donors and 91.0% in kidney transplant recipients with statistical significance observed for age, geographical location, and between donors and recipients. We analyzed 1,764 pairs of donors and recipients, of which 91.4% were categorized as having intermediate risk. Conclusions: The results of this study showed high cytomegalovirus infection rates in Colombia. Given the risk, categorization of patients undergoing transplants, measures should be adopted by medical teams to minimize risks.
Downloads
References
Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, et al. Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science. 2010;328:102-6. http://dx.doi.org/10.1126/science.1185350
Schnitzler MA, Lowell JA, Hardinger KL, Boxerman SB, Bailey TC, Brennan DC. The association of cyto-megalovirus sero-pairing with outcomes and costs following cadaveric renal transplantation prior to the introduction of oral ganciclovir CMV prophylaxis. Am J Transplant. 2003;3:445-51. http://dx.doi.org/10.1034/j.1600-6143.2003. 00069.x
Arthurs SK, Eid AJ, Pedersen RA, Kremers WK, Cosio FG, Patel R, et al. Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation. Clin Infect Dis. 2008;46:840-6. http://dx.doi.org/10.1086/528718
Bataille S, Moal V, Gaudart J, Indreies M, Purgus R, Dussol B, et al. Cytomegalovirus risk factors in renal transplantation with modern immunosuppression. Transpl Infect Dis. 2010;12:480-8. http://dx.doi.org/10.1111/j.1399-3062.2010.00533.x
Enders G, Daiminger A, Lindemann L, Knotek F, Bäder U, Exler S, et al. Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996-2010. Med Microbiol Immunol. 2012;201: 303-9. http://dx.doi.org/10.1007/s00430-012-0232-7
Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalo-virus seroprevalence and demographic characteristics associated with infection. Rev Med Virol. 2010;20:202-13. http://dx.doi.org/10.1002/rmv.655
Lopo S, Vinagre E, Palminha P, Paixao MT, Nogueira P, Freitas MG. Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003. Euro Surveill. 2011;16:19896.
Vilibic-Cavlek T, Ljubin-Sternak S, Ban M, Kolaric B, Sviben M, Mlinaric-Galinovic G. Seroprevalence of TORCH infections in women of childbearing age in Croatia. J Matern Fetal Neonatal Med. 2011;24:280-3. http://dx.doi.org/10.3109/14767058.2010.485233.
Adjei AA, Armah HB, Gbagbo F, Boamah I, Adu-Gyamfi C, Asare I. Seroprevalence of HHV-8, CMV and EBV among the general population in Ghana, West Africa. BMC Infect Dis. 2008;8:111. http://dx.doi.org/10.1186/1471-2334-8-111
Ministerio de Salud y Protección Social. Decreto 2493 de 2004. Por el cual se reglamentan parcialmente las Leyes 9ª de 1979 y 73 de 1988, en relación con los componentes anatómicos. Diario Oficial No.45631. Bogotá: Imprenta Nacional de Colombia; 2004.
Instituto Nacional de Salud. Documento técnico nacional. Comisión de Riñón. 6ª versión, 2014. Fecha de consulta: 10 de junio de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Marco%20Legal%20documentos%20tcnicos%20y%20estadistica%20red%20d/COMISION%20RI%C3%91ON%20Version%20No%206%20-2014.pdf.
Instituto Nacional de Salud. Informe red donación y trasplantes 2010. Fecha de consulta: mayo 10 del 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe%20FinalRed%20D%20Tx%20-%202010.pdf.
Instituto Nacional de Salud. Informe anual, Red de Donación y Trasplantes. Volumen 1, Bogotá, 2011. Fecha de consulta: 10 de mayo de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe%20Red%20Donacion%20y%20Trasplantes%20%20Vol%201%202011.pdf.
Instituto Nacional de Salud. Informe anual, Red de Donación y Trasplantes. Volumen 2, Bogotá, 2012. Fecha de consulta: 10 de mayo de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe_Red%20donacion%20y%20trasplantes%20Vol2_2012.pdf.
Instituto Nacional de Salud. Informe anual, Red de Donación y Trasplantes. Volumen 3, Bogotá, 2013. Fecha de consulta: 10 de mayo de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/INFORME%20ANUAL%202013%20RED%20DE%20DONACION%20Y%20TRASPLANTES.%20Vol%2003.pdf.
Beltrán M, Ayala M, Jara J. Frecuencia de grupos sanguíneos y factor Rh en donantes de sangre, Colombia, 1996. Biomédica. 1999;19:39-44. http://dx.doi.org/10.7705/biomedica.v19i1.1006
Korcáková L, Kaslík J, Svobodová J, Kaslíková J, Bláha J, Sedlácková E, et al. CMV infection in patients with chronic renal failure and in those following transplantation. Czech Med. 1988;11:131-6.
Sibrowski W, Kühnl P, Kalmar G, Albert S, Böhm BO, Doerr HW. Cytomegalovirus diagnosis in blood donors and risk patients. Beitr Infusionsther. 1990;26:37-9.
Trkulic M, Jovanovic D, Ostojic G, Kovacevic Z, Taseski J. Cytomegalovirus infection in patients with kidney diseases. Vojnosanit Pregl. 2000;57:63-7.
Vilibic T, Kolaric B, Ljubin S, Kos M, Kaic B, Mlinaric G. Prevalence and dynamics of cytomegalovirus infection among patients undergoing chronic hemodialysis. Indian J Nephrol. 2015;25:95-98. http://dx.doi.org/10.4103/0971-4065.139488
Betjes MG, Litjens NH, Zietse R. Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease. Nephrol Dial Transplant. 2007;22:3298-303. http://dx.doi.org/10.1093/ndt/gfm348
Kao TW, Hsu WA, Chen HS, Chen WY. A two year follow-up study of common virus infections in hemodialysis patients in Taiwan. Artif Organs. 2002;26:879-83. http://dx. doi.org/10.1046/j.1525-1594.2002.07053.x
Jha V. Post-transplant infections: An ounce of prevention. Indian J Nephrol. 2010;20:171-8. http://dx.doi.org/10. 4103/0971-4065.73431
Cordero E, Casasola C, Ecarma R, Danguilan R. Cytomegalovirus disease in kidney transplant recipients: Incidence, clinical profile, and risk factors. Transplant Proc. 2012;44:694-700. http://dx.doi.org/10.1016/j.transproceed. 2011.11.053
Cavdar C, Celtik A, Saglam F, Sifil A, Atila K, Celik A, et al. Cytomegalovirus disease in renal transplant recipients: A single-center experience. Ren Fail. 2008;30:503-6. http://dx.doi.org/10.1080/08860220802064705
Enan KA, El-Hussein AM, El Eragi A, Elkhider IM. Sero-reactivity to human cytomegalovirus in a cohort of Sudanese renal transplant patients. Khartoum Med J. 2009;2:197-9.
Sagedal S, Nordal KP, Hartmann A, Degre M, Holter E, Foss A, et al. A prospective study of the natural course of cytomegalovirus infection and disease in renal allograft recipients. Transplantation. 2000;70:1166-74.
Correa MR, Correa M, Arbeláez M, Builes M, Ossa J. Prevalencia de infección por citomegalovirus en receptores y donantes de trasplante renal en Medellín para 1988-1989. Acta Médica Colombiana. 1990;15:175-9.
Diaz J, Henao J, Rodelo J, García A, Arbeláez M, Jaimes F. Incidence and risk factors for cytomegalovirus disease in a Colombian cohort of kidney transplant recipients. Transplant Proc. 2014;46:160-6. http://dx.doi.org/10.1016/j.transproceed.2013.07.070
Kotton CN, Kumar D, Caliendo AM, Asberg A, Chou S, Danziger-Isakov L, et al. Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation. 2013;96:333-60. http://dx.doi.org/10.1097/TP.0b013e31829df29d
Cortés JA, Yomayusa N, Arias YR, Arroyave IH, Cataño JC, García P, et al. Consenso colombiano para la estratificación, diagnóstico, tratamiento y prevención de la infección por citomegalovirus en pacientes adultos con trasplante renal. Infectio. 2016. http://dx.doi.org/10.1016/j.infect.2015.10.005
Some similar items:
- Doracelly Hincapié, Marcela Acevedo, María Cristina Hoyos, Jesús Ochoa, Catalina González, Paula Andrea Pérez, Adriana Molina, Blanca Isabel Restrepo, Marcela Arrubla, Adriana Patricia Echeverri, Rita Elena Almanza, Luz Denise González, Eduardo Santacruz-Sanmartín, Norma Elena Orrego, Daniel Arango, Aura María Gutiérrez, Olga Lucía Londoño, Luz Maribel Toro, Mónica Ríos, Oscar Villada, Luz Aida Mejía, Paola Andrea Arenas, Diego García, Elkin Osorio, Serosurveillance for vaccine-preventable diseases: A look inside the pertussis experience , Biomedica: Vol. 39 No. Supl. 2 (2019): Enfermedades transmisibles en el trópico, agosto
- Ernesto Pérez-Sánchez, Raúl Montiel-Cruz, Eréndira Romero-Domínguez, Griselda Pascacio-Bermúdez, Arturo Báez-Hernández, Guadalupe Díaz del Castillo-Flores, Fabián Correa-Morales, Gonzalo Vázquez-Prokopec, Pablo Manrique-Saide, Azael Che-Mendoza, Gabriela Meneses-Ruiz , Irma López-Martínez, María Jesús Sánchez, Seroprevalence of Trypanosoma cruzi among children from Veracruz, Mexico: Epidemiological baseline for a control model based on Chagas disease active transmission , Biomedica: Vol. 44 No. 1 (2024)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |