Frequency of HLA alleles class I and II in a cohort of northwestern Colombian patients with spondyloarthritis
Abstract
Introduction. Spondyloarthritis is a chronic rheumatic disease that affect the axial skeleton and peripheral joints, along with several extra-articular manifestations. The association with HLA-B27 remains one of the strongest known links between these entities and the major histocompatibility complex. However, the global distribution of HLA-B27 varies considerably and furthermore, associations with non-HLA-B27 genes have been described.
Objective. The frequency of HLA class I and II was determined in a population of patients with spondyloarthritis with respect to detection in the clinical setting and by radiology.
Materials and methods. A descriptive, observational, cross-sectional, retrospective and prospective study was conducted in 56 patients from northwestern Colombia. Each was diagnosed with spondyloarthritis between 2005 and 2008. In each case, alleles were identified for the loci HLA class I and II (HLA-B; HLADQB1 and HLADRB). The frequency of these alleles in the axial, peripheral,
extraarticular and radiological manifestations.
Results.The frequency of HLA-B27 was 50% overall, and it was the most frequent allele. The two other alleles were HLA.DRB4*01 at 35.7% and HLA-DQB1*0501 at 28.6%, as detected in each of the clinical and radiological manifestations. A high frequency of HLA-B27 and HLA-DRB4*01 (64.3%) was noted in patients with dactylitis.
Conclusion. The alleles HLA-B27, HLA-DRB4*01 and HLA-DQB1*0501 were common in the different subtypes of spondyloarthritis and were frequent in the specific clinical axial, peripheral and extraarticular clinical manifestations, as well as radiological sacroiliitis.
Downloads
References
Kchir MM, Hamdi W, Laadhar L, Kochbati S, Kaffel D, Saadellaoui K, et al. HLA-B, DR and DQ antigens polymorphism in Tunisian patients with ankylosing spondylitis (a case-control study). Rheumatol Int. 2010;30:933-9.
Australo-Anglo-American Spondyloarthritis Consortium (TASC), Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010;42:123-7.
Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, et al. Interaction between ERAP1 and HLAB27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011;43:761-7.
Londoño J, Ávila M, Iglesias A, Cuéllar ML, Espinosa L, Valle R. Outcome of patients with undifferentiated seronegative spondyloarthropathy. Arthritis Rheum. 1997;40(Suppl.1):270.
Martínez B, Caraballo L, Hernández M, Valle R, Ávila M, Iglesias A. HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia. Rev Invest Clin. 1999;51:221-6.
Londoño JD, González LA, Ramírez LA, Santos P, Ávila M, Santos AM, et al. Caracterización de las espondiloartropatías y determinación de factores de mal pronóstico en una población de pacientes colombianos. Rev Colomb Reumatol. 2005;12:195-207.
Sampaio-Barros PD, Bertolo MB, Kraemer MH, Neto JF, Samara AM. Primary ankylosing spondylitis: Patterns of disease in a Brazilian population of 147 patients. J Rheumatol. 2001;28:560-5.
Fraga A, Gorodezky C, Lavalle C, Castro-Escobar LE, Magaña L, Escobar-Gutiérrez A. HLA-B27 in Mexican patients with ankylosing spondylitis. Arthritis Rheum. 1979;22:302.
Kaipiainen-Seppanen O, Aho K, Heliovaara M. Incidence and prevalence of ankylosing spondylitis in Finland. J Rheumatol. 1997;24:496-9.
Liao HT, Lin KC, Chen CH, Liang TH, Lin MW, Tsai CY, et al. Human leukocyte antigens in undifferentiated spondyloarthritis. Semin Arthritis Rheum. 2007;37:198-201.
Bautista W, Londoño J, Porras M, Valle R. Clinical and demographic characterization of a Colombian cohort of patients with diagnosis of spondylarthritis. Arthritis Rheum. 2010;62(Suppl.10):517.
Reveille JD, Arnett FC. Spondyloarthritis: Update on pathogenesis and management. Am J Med. 2005;118:592-603.
Bennett AN, McGonagle D, O’Connor P, Hensor EM, Sivera F, Coates LC, et al. Severity of baseline magnetic resonance imaging-evident sacroiliitis and HLA-B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years. Arthritis Rheum. 2008;58:3413-8.
Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): Validation and final selection. Ann Rheum Dis. 2009;68:777-83.
Rudwaleit M. New approaches to diagnosis and classification of axial and peripheral spondyloarthritis. Curr Opin Rheumatol. 2010;22:375-80.
Londoño J, Porras M, Calvo E, Santos P, Bautista W, Romero-Sanchez C, et al. The new ASAS classification criteria for axial and peripheral spondylarthritis: Valid in the Latin American patients, but… Arthritis Rheum. 2010;62(Suppl.10):552.
Atagunduz P, Aydin SZ, Bahadir C, Erer B, Direskeneli H. Determinants of early radiographic progression in ankylosing spondylitis. J Rheumatol. 2010;37:2356-61.
McGonagle D, Marzo-Ortega H, O’Connor P, Gibbon W, Pease C, Reece R, et al. The role of biomechanical factors and HLA-B27 in magnetic resonance imaging-determined bone changes in plantar fascia enthesopathy. Arthritis Rheum. 2002;46:489-93.
Siegel DM, Baum J. HLA-B27 associated dactylitis in children. J Rheumatol. 1988;15:976-7.
Lorette G, Despert F. HLA-B27-associated dactylitis in a child. Presse Med. 2006;35:249.
Padula A, Giasi V, Olivieri I. Elderly onset isolated B27 associated dactylitis. Ann Rheum Dis. 2002;61:759-60.
Sanghvi C, Mercieca K, Jones NP. Very severe HLA B27-associated panuveitis mimicking endophthalmitis: A case series. Ocul Immunol Inflamm. 2010;18:139-41.
Accorinti M, Iannetti L, Liverani M, Caggiano C, Gilardi M. Clinical features and prognosis of HLA B27-associated
acute anterior uveitis in an Italian patient population. Ocul Immunol Inflamm. 2010;18:91-6.
Siala M, Mahfoudh N, Fourati H, Gdoura R, Younes M, Kammoun A, et al. MHC class I and class II genes in Tunisian patients with reactive and undifferentiated arthritis. Clin Exp Rheumatol. 2009;27:208-13.
Ward MM, Hendrey MR, Malley JD, Learch TJ, Davis JC Jr, Reveille JD, et al. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. Arthritis Rheum. 2009;61:859-66.
Ho PY, Barton A, Worthington J, Plant D, Griffiths CE, Young HS et al. Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: Comparison with psoriasis and undifferentiated inflammatory arthritis. Ann Rheum Dis. 2008;67:677-82.
Pérez-Guijo V, Muñoz E, Escudero A, Veroz R, Sánchez M, Muñoz-Villanueva MC, et al. Distribution of HLA-DRB1 genes in patients with sporadic ankylosing spondylitis in the south of Spain. Joint Bone Spine. 2002;69:458-62.
Vargas-Alarcón G, Londoño JD, Hernández-Pacheco G, Pacheco-Tena C, Castillo E, Cardiel MH, et al. Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients. Ann Rheum Dis. 2002;61:714-7.
Maksymowych WP, Gorodezky C, Olivo A, Alaez C, Wong C, Burgos-Vargas R, et al. HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy. J Rheumatol. 1997;24:904-7.
Tuokko J, Reijonen H, Ilonen J, Anttila K, Nikkari S, Möttönen T, et al. Increase of HLA-DRB1*0408 and -DQB1*0301 in HLA-B27 positive reactive arthritis. Ann Rheum Dis. 1997;56:37-40.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
