Recommendations on vaccination in children and adolescents with inborn errors of immunity according to the expanded Colombian immunization programme

Abstract

In this manuscript, an exhaustive analysis of the global recommendations for immunization in Inborn Errors of immunity (IEI) was carried out, the mechanisms of action and types of vaccines were examined, the vaccines included in the Colombian immunization program were described, followed by specific guidelines for immunization in patients with the most frequent IEI in Colombia. These recommendations were adjusted according to the severity and subclassifications of each IEI, considering variations in the immune response with the aim of offering evidence-based recommendations for vaccination in children with the most common IEI worldwide considering the vaccines included in the Colombian immunization program to avoid delays in vaccination schedules. All this was achieved through a narrative, non-systematic review of articles indexed in both Spanish and English, using MeSH terms such as: “Inborn errors of immunity”, “primary immunodeficiencies”, “vaccination in IEI, “types of vaccines”, “mechanism of action of vaccines”, “live vaccines in IEI”. Using search engines such as: PubMed, Medline, ScienceDirect and websites of recognized institutions such as the CDC website.