Susceptibilidad de aislamientos de Neisseria gonorrhoeae a la penicilina y a la tetraciclina

Abstract

A surveillance program of the antimicrobial susceptibility was established to determine antimicrobial resistance to Neisseria gonorrhoeae. We used the Kirby Bauer test to show that 42 out of 43 N. gonorrhoeae isolates of non beta lactamase producers (NBLP) presented an intermediate susceptibility level to penicillin. 26 of the same isolates were resistant to tetracycline. The minimal inhibitory concentration (MIC) to the two antimicrobials was determined in the 100 N. gonorrhoeae isolates from an STD program. From these 100 isolates, 49 were NPBL and 51 were PBL. MIC's to penicillin from the isolates PBL were interpreted as sensitive (2pg/mL) in 5. MIC's to penicillin from the isolates PBL showed that 4 were intermediate and 47 resistant. MIC's to tetracycline showed 4 isolates sensitive (<0.25pg/mL), 18 intermediate (0,5-lpgImL) and 72 isolates resistant (>2pglmL). This study indicated the need for surveillance programs for management of antimicrobial susceptibility of N. gonorrhoeae and treatment schedules.