Efecto de la permeabilidad en la regeneración del nervio ciático entubado de rata

Abstract

Sectioned rat sciatic nerves were placed in regeneration chambers, leaving a gap of 10 mm2 between the proximal and distal stumps. The walls of these chambers carried none, two or nine 4 mm2 holes. One, two or four weeks after the surgery, animals were perfused and regenerates' histology was evaluated. In addition, in the 4 week group, the number of myelinated fibers and the surface of the regenerates were evaluated at mid-tube level. An acceleration of the regenerative process was observed, depending on the number of holes. The number of myelinated fibers and the size of the regenerates also increase proportionally with the number of holes in the tubes.