Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma

Alamira Farah Alwiraikat-Flores, Pablo Octavio-Aguilar, .

Palabras clave: enfermedad de Alzheimer, ATPasas transportadoras de calcio, trastornos del metabolismo del calcio, receptor de N-metil-D-aspartato, retículo endoplásmico

Resumen

Hay muchos factores implicados en la incidencia de la enfermedad de Alzheimer que, en combinación, terminan por impedir o dificultar las funciones neuronales normales.
Actualmente, poco se conoce sobre la regulación del calcio, antes de la enfermedad y durante la misma. La inestabilidad interna de los niveles de calcio se asocia a un mayor riesgo vascular, condición prevalente en un gran número de individuos ya comprometidos por la enfermedad de Alzheimer.
Esta revisión proporciona una reevaluación de los mecanismos moleculares de la ATPasa dependiente de Ca2+ del retículo sarcoendoplásmico (SERC-A) en la enfermedad y analiza los aspectos más destacados de la función de los canales de calcio dependientes de voltaje; de esta manera, se podrán abrir nuevas alternativas de tratamiento. Estos mecanismos de regulación son clínicamente relevantes, ya que se ha implicado la función irregular de SERC-A en diversas alteraciones de la función cerebral.

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Cómo citar
1.
Alwiraikat-Flores AF, Octavio-Aguilar P. Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma. biomedica [Internet]. 30 de marzo de 2023 [citado 29 de febrero de 2024];43(1):51-60. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/6704

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2023-03-30
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