Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia

Luz E. Botero, Andrés E. Toro, Alber J. Patiño, Guillermo Salazar, Juan C. Rodríguez, Juan C. Suárez-Escudero, Gustavo A. Alarcón, Ana Corcimaru, Cristina Osorio, Joseph S. Y. Jeong, Oscar Alzate, .

Palabras clave: enfermedad de Alzheimer, diabetes mellitus, apolipoproteína E, demencia, enfermedad pulmonar obstructiva crónica

Resumen

Introducción. La enfermedad de Alzheimer es compleja y afecta, aproximadamente, a 20 millones de personas en todo el mundo. Muchas variables parecen aumentar el riesgo de desarrollar esta alteración neurológica. Entre los factores de riesgo, se ha demostrado ampliamente que la diabetes mellitus y la isoforma ε4 del gen APOE tienen incidencia positiva en el desarrollo de la enfermedad. Se reporta un estudio en el cual se investigó la posible correlación entre APOE, diabetes mellitus yla enfermedad de Alzheimer, en un grupo específico de pacientes del departamento de Antioquia, Colombia.

Objetivo. Determinar si existe una correlación entre APOE, diabetes mellitus y la enfermedad de Alzheimer, en un grupo de pacientes de Antioquia, Colombia.

Materiales y métodos. Se buscaron y analizaron las historias clínicas de los pacientes con diagnóstico de enfermedad de Alzheimer. Se seleccionaron aquellos que cumplían los criterios de inclusión. Se utilizaron métodos comercialmente disponibles para confirmar la presencia de diabetes mellitus. La genotipificación de APOE se hizo con un método basado en la PCR y la digestión con enzimas de restricción, en muestras de todos los participantes en el estudio.

Resultados. En este estudio se analizan 43 casos de enfermedad de Alzheimer y 43 individuos sanos controles, pareados por edad y sexo. Las enfermedades concomitantes no neurológicas más comunes fueron: hipertensión arterial, infarto agudo del miocardio, enfermedad pulmonar obstructiva crónica e hipotiroidismo.Conclusiones. De las diferentes variables investigadas, dos arrojaron resultados concluyentes: i) la presencia de la enfermedad de Alzheimer es más frecuente en pacientes con diabetes mellitus, y 2) no se encontró correlación entre la enfermedad de Alzheimer de inicio tardío esporádico y el genotipo de APOE. Es importante indicar que debe llevarse a cabo un estudio con un tamaño de población mayor, para determinar cualquier posible correlación o inferencia con el genotipo de APOE.

 

doi: http://dx.doi.org/10.7705/biomedica.v32i2.579

 

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  • Luz E. Botero Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia Grupo de Biología Estructural y Proteómica Group, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Andrés E. Toro Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Alber J. Patiño Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Guillermo Salazar Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Juan C. Rodríguez Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Juan C. Suárez-Escudero Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Gustavo A. Alarcón Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia
  • Ana Corcimaru Grupo de Biología Estructural y Proteómica Group, Universidad Pontificia Bolivariana, Medellín, Colombia Systems Proteomics Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, USA
  • Cristina Osorio Grupo de Biología Estructural y Proteómica Group, Universidad Pontificia Bolivariana, Medellín, Colombia Systems Proteomics Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, USA
  • Joseph S. Y. Jeong Grupo de Biología Estructural y Proteómica Group, Universidad Pontificia Bolivariana, Medellín, Colombia Systems Proteomics Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, USA
  • Oscar Alzate Grupo de Biología Estructural y Proteómica Group, Universidad Pontificia Bolivariana, Medellín, Colombia Systems Proteomics Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, USA

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Cómo citar
Botero, L. E., Toro, A. E., Patiño, A. J., Salazar, G., Rodríguez, J. C., Suárez-Escudero, J. C., Alarcón, G. A., Corcimaru, A., Osorio, C., Jeong, J. S. Y., & Alzate, O. (2012). Diabetes mellitus en pacientes con enfermedad de Alzheimer: descripción clínica y correlación con el genotipo APOE en una muestra de población del departamento de Antioquia, Colombia. Biomédica, 32(2), 239-51. https://doi.org/10.7705/biomedica.v32i2.579
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2012-06-30
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