Sternal osteomyelitis and scrofuloderma due to BCG vaccination.
Keywords:
mycobacterium bovis, BCG vaccine adverse effects, osteomyelitis, microbiology
Abstract
BCG vaccine has been used for nearly 100 years in the prevention of tuberculosis. The case of a 13 month-old girl vaccinated as a newborn with BCG is described as presenting a sternal mass with associated periostic erosion. The mass was resected, and histopathological examination revealed a chronic inflammatory reaction with caseous granulomas, and extension to bone and skin. PCR amplifications using specific primers for Mycobacterium tuberculosis on paraffin-embedded tissue were negative. BCG vaccination at birth, the histological appearance and the absence of M. tuberculosis DNA in the resected tissue indicated that osteomyelitis and scrofuloderma were a consequence of BCG. Osteomyelitis is a rarely occurring adverse effect of BCG vaccination, more commonly seen in immunosuppressed patients. In the patient described above, no symptoms of immunodeficiency were seen, however.Downloads
Download data is not yet available.
How to Cite
1.
Corrales IF, Cortés JA, Mesa ML, Zamora G. Sternal osteomyelitis and scrofuloderma due to BCG vaccination. biomedica [Internet]. 2003 Jun. 1 [cited 2024 May 19];23(2):202-7. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1212
Some similar items:
- Gloria Heresi, Germán A. Contreras, Norma Pérez, James R. Murphy, Thomas G. Cleary, Empyema necessitans and acute osteomyelitis associated with community acquired methicillin resistant Staphylococcus aureus in an infant , Biomedica: Vol. 29 No. 4 (2009)
- Leonardo F. Jurado, Martha I. Murcia, Patricia Hidalgo, John E. Leguizamón, Lorena R. González, Phenotypic and genotypic diagnosis of bone and miliary tuberculosis in an HIV+ patient in Bogotá, Colombia , Biomedica: Vol. 35 No. 1 (2015)
- Sara Catalina Penagos, Sebastián Gómez, Pablo Villa, Santiago Estrada, Carlos Andrés Agudelo, Osteomyelitis due to Yokenella regensburgei following craniotomy in an immunocompetent patient , Biomedica: Vol. 35 No. 4 (2015)
- Anna Carolina Ratto-Tespestini, Paula Juliana Pérez-Chaparro, Giuseppe Alexandre Romito, Luciene Cristina Figueiredo, Marcelo Faveri, Hilana Paula Carillo, Priscila Larcher, Magda Feres, Comparison of independent and dependent culture methods for the detection of transient bacteremia in diabetic subjects with chronic periodontitis , Biomedica: Vol. 36 No. 1 (2016)
- Julio César Martínez, Claudia Llerena, Yanely Angélica Valbuena, The Importance of investigating Mycobacterium bovis in clinical samples of human origin , Biomedica: Vol. 39 No. Sp. 1 (2019): Suplemento 1, Microbiología médica, mayo
- Carlos Martínez-Canseco, Rebecca E. Franco-Bourland, Norma González-Huerta, Marco Antonio Paredes-Espinosa, Silvia Giono-Cerezo, Laura Sánchez-Chapul, Rogelio Paniagua-Pérez, René Valdez-Mijares, C Hernández-Flores, Detection and expression of SapS, a class C nonspecific acid phosphatase with O-phospho-Ltyrosine- phosphatase activity, in Staphylococcus aureus isolates from patients with chronic osteomyelitis , Biomedica: Vol. 43 No. 2 (2023)
Published
2003-06-01
Issue
Section
Case presentation
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
