Clinical profile of dengue in patients consulting a tertiary hospital in the city of Cali, Colombia, 2013
Abstract
Introduction: Dengue virus infection is amongst the most important arboviral diseases in the country and has become a major global public health concern. Objective: To describe the clinical profile of patients with dengue virus infection hospitalized in a tertiary hospital in the city of Cali, Colombia. We also describe the trend analysis of the number of cases by epidemiological weeks in 2013. Materials and methods: We conducted a retrospective study of admitted patients suspected to have dengue infection in the Rafael Uribe Uribe Clinic in the year 2013. Patients with serological confirmation of dengue infection were classified according to the World Health Organization classification. Subsequently, the clinical parameters of the patients with dengue were described. Results: Of the 1,173 patients with suspected dengue, 287 (24.5%) were confirmed serologically; 152 (53%) were women and 135 (47%) males; 40.1% had no warning signs, 3.8% had warning signs and 25.1% had severe manifestations. The most common symptoms were fever (287;100%), myalgia (223;78%), and headache (183:64%). Hemorrhagic manifestations were recorded in 100 (34.8%) patients; 4 (1.4%) had neurological manifestations. Three deaths (0.7%) were reported, two of which were associated with sickle cell disease. Conclusions: The severe form of the infection and mortality from dengue reported during the outbreak was more frequent in the pediatric population. It is suggested to implement strategies to ensure specific attention to patients with comorbidities such as sickle cell disease.
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Kulkarni RD, Patil SS, Ajantha GS, Upadhya AK, Kalabhavi AS, Shubhada RM, et al . Association o f platelet count and serological markers of dengue infection - importance of NS1 antigen. Indian J Med Microbiol. 2011;29:359-62. http://dx.doi.org/10.4103/0255-0857.90159
Hermann LL, Thaisomboonsuk B, Poolpanichupatam Y, Jarman RG, Kalayanarooj S, Nisalak A, et al . Evaluation of a dengue NS1 antigen detection assay sensitivity and specificity for the diagnosis of acute dengue virus infection. PloS Negl Trop Dis . 2014;8:e3193. http://dx.doi.org/10.1371/journal.pntd.0003193
Datta S, Wattal C. Dengue NS1 antigen detection: A useful tool in early diagnosis of dengue virus infection. Indian J Med Microbiol. 2010;28:107-10. http://dx.doi.org/10.4103/0255-0857.62484
Cavalcanti LP, Coelho IC, Vilar DC, Holanda SG, Escóssia KN, Souza-Santos R. Clinical and epidemiological characterization of dengue hemorrhagic fever cases in northeastern, Brazil. Rev Soc Bras Med Trop. 2010;43:355-8. http://dx.doi.org/10.1590/S0037-86822010000400003
Cordeiro MT, Silva AM, Brito CA, Nascimento EJ, Magalhães MC, Guimarães GF, et al . Characterization of a dengue patient cohort in Recife, Brazil. Am J Trop Med Hyg. 2007;77:1128-34.
Ministerio de la Protección Social. Guía de atención integral del paciente con dengue, 2010. Fecha de consulta: 20 de octubre de 2014. Disponible en: http://www.minsalud.gov.co/Documentos%20y%20Publicaciones/Gu%C3%ADa%20para%20la%20atenci%C3%B3n%20cl%C3%ADnica%20integral%20del%20paciente%20con%20dengue.pdf.
Ministerio de Salud. Situación actual de dengue a semana 12 de 2013. Periodo de análisis: 2008-2013. Fecha de consulta: 10 de noviembre de 2014. Disponible en: http://www.minsalud.gov.co/Documento s%20y%20Publicaciones/INFORME%20SITUACION%20DE%20DENGUE.pdf.
Capeding MR, Chua MN, Hadinegoro SR, Hussain II, Nallusamy R, Pitisuttithum P, et al . Dengue and other common causes of acute febrile illness in Asia: An active surveillance study in children . PLoS Negl Trop Dis. 2013; 7:e2331. http://dx.doi.org/10.1371/journal.pntd.0002331
Simmons CP, Farrar JJ, Nguyenv V, Wills B. Dengue. N Engl J Med. 2012;366:1423-32. http://dx.doi.org/ 10.1056/NEJMra1110265
Hsieh CJ, Chen MJ. The commercial dengue NS1 antigen- capture ELISA may be superior to IgM detection, virus isolation and RT-PCR for rapid laboratory diagnosis of acute dengue infection based on a single serum sample. J Clin Virol. 2009;44:102. http://dx.doi.org/10.1016/j.jcv.2008.10.003
World Health Organization. Dengue haemorrhagic fever: Diagnosis, treatment, prevention and control. 2nd edition. Geneva: WHO; 1997. p. 12-23.
Organización Panamericana de la Salud. Dengue: guías de atención para enfermos en la región de las Américas 2010. Fecha de consulta: 4 de mayo de 2015. Disponible en: http://www.paho.org/hq/index.php?option=com_docman &task=doc_view&gid=11239&Itemid.
Chakravarti A, Arora R, Luxemburger C. Fifty years of dengue in India. Trans R Soc Trop Med Hyg. 2012;106:273- 82. http://dx.doi.org/10.1016/j.trstmh.2011.12.007
Pires Neto R da J, de Sá SL, Pinho SC, Pucci FH, Teófilo CR, Evangelista PD, et al . Dengue infection in children and adolescents: Clinical profile in a reference hospital in northeast Brazil. Rev Soc Bras Med Trop. 2013;46:765-8. http://dx.doi.org/10.1590/0037-8682-1716-2013.
González AL, Martínez RA, Villar LA. Evolución clínica de pacientes hospitalizados por dengue en una institución de salud de Bucaramanga, Colombia. Biomédica. 2008;28:531-43. http://dx.doi.org/10.7705/biomedica.v28i4.58
Sahana KS, Sujatha R. Clinical profile of dengue among children according to revised WHO classification: Analysis of a 2012 outbreak from southern India. Indian J Pediatr. 2015;82:109-13 . http://dx.doi.org/10.1007/s12098-014-1523-3
Khan NA, Azhar EI, El-Fiky S, Madani HH, Abuljadial MA, Ashshi AM, et al . Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop 2008;105:39-44. http://dx.doi.org/10.1016/j.actatropica.2007.09.005
Karoli R, Fatima J, Siddigi Z, Kazmi KI, Sultania AR. Clinical profile of dengue infection at teaching hospital in North India. J Infect Dev Ctries. 2012;6:551-4. http://dx.doi.org/10.3855/jidc.2010
Gunasekaran P, Kaveri K, Mohana S, Arunagiri K, Babu BV, PriyaPP, et al . Dengue disease status in Chennai (2006-2008): A retrospective analysis. Indian J Med Res. 2011;133:322-5.
Kabilan L, Balasubramanian S, Keshava S, Satyanarayana K. The 2001 dengue epidemic in Chennai. Indian J Pediatr. 2005;72:919-23.
Chakravarti A, Kumaria R. Eco- epidemiological analysis of dengue infection during an outbreak of dengue fever, India. Virol J. 2005;2:32. http://dx.doi.org/10.1186/1743-422X-2-32
Mattar S, Morales V, Cassab A, Rodríguez-Morales AJ. Effect of climate variables on dengue incidence in a tropical Caribbean municipality of Colombia, Cereté, 2003-2008. Int J Infect Dis. 2013;17:e358-9. http://dx.doi.org/10.1016/j.ijid.2012.11.021.
Rosero MJ, Bermúdez AJ. Análisis de hemoglobinopatías en regiones afrocolombianas usando muestras de sangre seca de cordón umbilical. Acta Med Colomb. 2012;37: 117- 26.
Sociedad Española de Hematología y Oncología Pediátricas. Guía de práctica clínica sobre la enfermedad de células falciformes pediátrica 2010. Fecha de consulta: 25 de noviembre de 2014. Disponible en: http://www.madrid.org/cs/Satellite?blobcol=urldata&blobheader=application%2Fpdf&blobheadername1=Content-disposition&blobheadername2=cadena&blobheadervalue1=filename%3DG+FALCIF+SEHOP+2010+pdf.pdf&blobheadervalue2=language%3Des%26site%3DPortalSalud&blobkey=id&blobtable=MungoBlobs&blobwhere=1272009829651&ssbinary=true.
Arroyave E, Londoño AF, Quintero JC, Agudelo-Flórez P, Arboleda M, Díaz FJ, et al . Etiología y caracterización epidemiológica del síndrome febril no palúdico en tres municipios del Urabá antioqueño, Colombia. Biomédica. 2013;33(Supl.1):99-107. http://dx.doi.org/10.7705/biomedica.v33i0.734
Moesker FM, Muskiet FD, Koeijers JJ, Fraaij PL, Gerstenbluth I, van Gorp EC, et al . Fatal dengue in patients with sickle cell disease or sickle cell anemia in Curaçao: Two case reports. PLoS Negl Trop Dis . 2013;7:e2203. http://dx.doi.org/10.1371/journal.pntd.0002203
Mosnier E, Demar M, Bernit E, Rousset D, Epelboin L, Nacher M, et al . Dengue infection in sickle cell patients in French Guiana. J Virol Retrovirol. 2015;2:106.
Cáceres-Manrique FM, Vesga-Gómez C, Angulo-Silva ML. Empowerment for dengue prevention and control. Rev Salud Pública (Bogotá). 2010;12:798-806. http://dx.doi.org/10.1590/S0124-00642010000500010
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