Nodular hepatic lesions secondary to myeloma IgA presenting as fever of unknown origin
Keywords:
Fever of unknown origin, multiple myeloma, liver, immunoglobulin A
Abstract
A 45 year old male presented with IgA multiple myeloma s/p (status post) autologous hematopoietic stem cell transplantation; and with a history of six weeks of fever and constitutional symptoms. Liver tests showed an infiltrative pattern, with ultrasound evidence of multiple nodular lesions. A laparoscopic biopsy identified circumscribed myeloma foci. This is the first reported case of myeloma nodular liver lesions causing a fever of unknown origin.Downloads
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References
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14. Fernandez-Florez A, Fortes J, Smucler A, Orduna M, Pol A. Involvement of the liver by multiple myeloma as nodular lesions: a case diagnosed by fine-needle aspiration and immunocytochemistry. Diagn Cytopathol. 2003;29:280-2.
15. Invernizzi R, Maffe GC, Travaglino E, Pagani E, Pieresca C. Nodular lesions of the liver in multiple myeloma. Haematologica. 2007;92:e81.
16. Pérez-Soler R, Esteban R, Allende E, Tornos-Salomo C, Julia A, et al. Liver involvement in multiple myeloma. Am J Hematol. 1985;20:25-9.
17. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Román M et al. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 2006;91:964-7.
18. Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M, et al. Clinical and pathological findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol. 2001;67:1-5.
19. Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: A case report and literature review. World J Gastroenterol. 2009;15:1014-7.
20. Edwards GA, Zawadzki ZA. Extraosseous lesions in plasma cell myeloma. A report of six cases. Am J Med.1967;43:194-205.
21. Wajima T, Teague OE. IgA-multiple myeloma presenting as plasmocytoma of the liver. J Clin Gastroenterol. 1992;15:270-1.
22. Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography-case report. Roentgenpraxis. 2008;56:249-53.
23. Mathieu D, Elouaer-Blanc L, Diviné M, René E, Vasile N. Hepatic plasmacytomas: Sonographic and CT findings. J Comput Assist Tomogr. 1986;10:144-5.
24. Nozza A, Castagna L, Rahal D, Magagnoli M, Santoro A. Massive liver involvement in a patient with multiple myeloma during thalidomide treatment. Haema. 2003;6:230-2.
2. Lin P. Plasma cell myeloma. Hematol Oncol Clin North Am. 2009;23:709-27.
3. Ochoa LF, Montoya LP. Mortalidad por cáncer en Colombia 2001. Revista CES Medicina. 2004;18:19-36.
4. Thomas FB, Clausen KP, Greenberger NJ. Liver disease in multiple myeloma. Arch Intern Med. 1973;132:195-202.
5. Nucci M, Anaissie E. Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clin Infect Dis. 2009;49:1211-25.
6. Hayes DW, Bennet WA, Heck FJ. Extramedullary lesions multiple myeloma. Arch Pathol. 1952;53:262-72.
7. Churg J, Gordon AJ. Multiple myeloma: Lesions of the extraosseous hemopoietic systems. Am J Clin Pathol. 1950;20:934-45.
8. Pasmantier MW, Azar HA. Extraskeletal spread in multiple cell myeloma: A review of 57 autopsied cases. Cancer. 1969;23:167-74.
9. Innes J, Newall J. Myelomatosis. Lancet. 1961;1:239-45.
10. Goel S, Ghesani M, Cohen S, Maslin P, Meka M, Chang A. Multiple myeloma presenting with [18F] fluorodeoxyglucose avid liver lesions diagnosed on positron emission tomography scan. J Clin Oncol. 2007;25:5319-20.
11. Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP. Multiple myeloma presenting as space occupying lesions of the liver. Cancer. 1990;65:2784-6.
12. Curtis JM, Pellegrini V, Tappin JA. Case report: multiple myeloma -a rare presentation. Clin Radiol. 1995;50:63-4.
13. Kelekis NL, Semelka RC, Warshauer DM, Sallah S. Nodular liver involvement in light chain multiple myeloma: appearance on US and MRI. Clin Imaging. 1997;21:207-9.
14. Fernandez-Florez A, Fortes J, Smucler A, Orduna M, Pol A. Involvement of the liver by multiple myeloma as nodular lesions: a case diagnosed by fine-needle aspiration and immunocytochemistry. Diagn Cytopathol. 2003;29:280-2.
15. Invernizzi R, Maffe GC, Travaglino E, Pagani E, Pieresca C. Nodular lesions of the liver in multiple myeloma. Haematologica. 2007;92:e81.
16. Pérez-Soler R, Esteban R, Allende E, Tornos-Salomo C, Julia A, et al. Liver involvement in multiple myeloma. Am J Hematol. 1985;20:25-9.
17. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Román M et al. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 2006;91:964-7.
18. Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M, et al. Clinical and pathological findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol. 2001;67:1-5.
19. Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: A case report and literature review. World J Gastroenterol. 2009;15:1014-7.
20. Edwards GA, Zawadzki ZA. Extraosseous lesions in plasma cell myeloma. A report of six cases. Am J Med.1967;43:194-205.
21. Wajima T, Teague OE. IgA-multiple myeloma presenting as plasmocytoma of the liver. J Clin Gastroenterol. 1992;15:270-1.
22. Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography-case report. Roentgenpraxis. 2008;56:249-53.
23. Mathieu D, Elouaer-Blanc L, Diviné M, René E, Vasile N. Hepatic plasmacytomas: Sonographic and CT findings. J Comput Assist Tomogr. 1986;10:144-5.
24. Nozza A, Castagna L, Rahal D, Magagnoli M, Santoro A. Massive liver involvement in a patient with multiple myeloma during thalidomide treatment. Haema. 2003;6:230-2.
How to Cite
1.
González GR, Navarro AM, Zambrano Ángela R, Arrunátegui AM. Nodular hepatic lesions secondary to myeloma IgA presenting as fever of unknown origin. biomedica [Internet]. 2010 Dec. 1 [cited 2024 May 18];30(4):478-81. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/285
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Published
2010-12-01
Issue
Section
Case presentation
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