Frequency of antibodies and seroconversion against Rickettsia spp in patients consulting health institutions in the department of Caldas, Colombia, 2016-2019
Abstract
Introduction: Rickettsioses are zoonotic diseases transmitted by arthropods acting as vectors and reservoirs. Disease symptoms are nonspecific and, therefore, their clinical diagnosis is difficult. Indirect immunofluorescence (IFA) is the gold standard assay for diagnosis. The interest for conducting studies on these pathologies has resurfaced in Colombia since 2001; besides, previous studies have evidenced cases of rickettsiosis in the north of the department of Caldas.
Objective: To establish the frequency of antibodies and seroconversion against Rickettsia spp. In patients consulting health institutions in Caldas, Colombia, from 2016 to 2019.
Materials and methods: We conducted a quantitative, observational, and descriptive study on a non-probabilistic sample of 175 patients with symptoms compatible with rickettsiosis who consulted in different municipalities of Caldas, Colombia; IFA was performed to detect antibodies in the acute and convalescent phases against Rickettsia rickettsii, Rickettsia typhi, and Rickettsia felis.
Results: The average age of the patients was 31 years. The municipalities with the highest proportion of seropositive cases were Belalcázar, Chinchiná, Filadelfia, La Dorada, La Merced, and Manizales; 66% of patients owned pets and 12% reported arthropod bites. The most frequent signs and symptoms were headache (69.7%), arthromyalgia (60%), and fever (58.2%). IgG seroprevalence was 60% for R. rickettsii, 47.9% for R. typhi, and, and 24% for R. felis. Eight patients presented seroconversion.
Conclusion: We found evidence of the circulation of Rickettsia species from the spotted fever group and the typhus group associated with human cases in Caldas.
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References
Cortés JA, Romero-Moreno LF, Aguirre-León CA, Pinzón-Lozano L, Cuervo SI. Enfoque clínico del síndrome febril agudo en Colombia. Infectio. 2016;21:39-50. https://doi.org/10.22354/in.v21i1.640
Ovalle M, Bello S, Rico A, Pardo L, Beltrán M, Duarte C, et al. Caracterización epidemiológica de síndrome febril en pacientes fallecidos en Colombia, 2011-2013. Inf Quinc Epidemiol Nac. 2016;21:266-77.
Instituto Nacional de Salud. Boletín Epidemiológico Semanal - Semana epidemiológica 53, 27 de diciembre de 2020 al 02 de enero de 2021. Fecha de consulta: 26 de mayo de 2010. Disponible en: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2020_Boletin_epidemiologico_semana_53.pdf
Raoult D. Introduction to rickettsioses, ehrlichioses, and anaplasmoses. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. Ninth edition. Philadelphia: Elsevier; 2020. p. 2198-205.
Merhej V, Angelakis E, Socolovschi C, Raoult D. Genotyping, evolution and epidemiological findings of Rickettsia species. Infect Genet Evol. 2014;25:122-37. https://doi.org/10.1016/j.meegid.2014.03.014
Adem P V. Emerging and re-emerging rickettsial infections. Semin Diagn Pathol. 2019;36:146-51. https://doi.org/10.1053/j.semdp.2019.04.005
Blanton LS. The Rickettsioses: A practical update. Infect Dis Clin North Am. 2019;33:213-29. https://doi.org/10.1016/j.idc.2018.10.010
Walker DH, Fishbein DB. Epidemiology of rickettsial diseases. Eur J Epidemiol. 1991;7:237-45. https://doi.org/10.1007/bf00145672
Snowden J, Ladd M, King KC. Rickettsial Infection. Fecha de consulta: 20 de enero de 2021. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK431127/
Robinson MT, Satjanadumrong J, Hughes T, Stenos J, Blacksell SD. Diagnosis of spotted fever group Rickettsia infections: The Asian perspective. Epidemiol Infect. 2019;147:e286. https://doi.org/10.1017%2FS0950268819001390
Binder AM, Nichols Heitman K, Drexler NA. Diagnostic methods used to classify confirmed and probable cases of spotted fever rickettsioses — United States, 2010-2015. MMWR Morb Mortal Wkly Rep. 2019;68:243-46. https://doi.org/10.15585/mmwr.mm6810a3
Chapman AS, Bakken JS, Folk SM, Paddock CD, Bloch KC, Krusell A, et al. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: A practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. 2006;55:1-27.
Raoult D, Parola P. Rocky Mountain spotted fever in the USA: A benign disease or a common diagnostic error? Lancet Infect Dis. 2008;8:587-9. https://doi.org/10.1016/s1473-3099(08)70210-x
Biggs HM, Behravesh CB, Bradley KK, Dahlgren FS, Drexler NA, Dumler JS, et al. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis - United States. MMWR Recomm Rep. 2016;65:1-44. https://doi.org/10.15585/mmwr.rr6502a1
Wilson LB, Chowning WM. The so-called “spotted fever” of the Rocky Mountains: A preliminary report to the Montana State Board of Health. JAMA. 1902;39:131-6.
Piza J, Meyer G, Gomes L. Typho exanthematico de São Paulo. Bol Of San Pan. 1933;12 980-3.
Patiño L, Afanador A, Paul JH. A spotted fever in Tobia, Colombia. Am J Trop Med Hyg. 1937;S1-17:639-53.
Miranda A, Flores S, Máttar S. Alta seroprevalencia de rickettsiosis en trabajadores del campo en el municipio de Ciénaga de Oro, Córdoba. Inf Quinc Epidemiol Nac. 2002;7:71-5.
Hidalgo M, Sánchez R, Orejuela L, Hernández J, Walker DH, Valbuena G. Prevalence of antibodies against spotted fever group rickettsiae in a rural area of Colombia. Am J Trop Med Hyg. 2007;77:378-80.
Hidalgo M, Orejuela L, Fuya P, Carrillo P, Hernández J, Parra E, et al. Rocky Mountain spotted fever, Colombia. Emerg Infect Dis. 2007;13:1058-60. https://doi.org/10.3201%2Feid1307.060537
Acosta J, Urquijo L, Diaz A, Sepúlveda M, Mantilla G. Brote de rickettsiosis en Necoclí, Antioquia, febrero-marzo de 2006. Inf Quinc Epidemiol Nac. 2006;11:177-92.
Pacheco-García O, Giraldo M, Hidalgo M, Galeano A, Echeverri I, Echavarría-Rodríguez L, et al. Estudio de brote febril hemorrágico en el corregimiento de Alto de Mulatos -Distrito Especial Portuario de Turbo, Antioquia, enero de 2008. Inf Quinc Epidemiol Nac. 2008;13:145-60.
Hidalgo M, Miranda J, Heredia D, Zambrano P, Vesga JF, Lizarazo D, et al. Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia. Mem Inst Oswaldo Cruz. 2011;106:117-18. https://doi.org/10.1590/S0074-02762011000100019
Londoño AF, Arango-Ferreira C, Acevedo-Gutiérrez LY, Paternina LE, Montes C, Ruiz I, et al. A cluster of cases of Rocky Mountain spotted fever in an area of Colombia not known to be endemic for this disease. Am J Trop Med Hyg. 2019;101:336-42. https://doi.org/10.4269/ajtmh.18-1007
Bonilla-S C. Tifus en Colombia, casos notificados al Sivigila hasta el treceavo periodo epidemiológico del año 2010. Fecha de consulta: 12 de febrero de 2020. Disponible en: https://www.ins.gov.co/buscador/Informesdeevento/Tifus%202010.pdf#search=tIFUS
Hidalgo M, Salguero E, de la Ossa A, Sánchez R, Vesga JF, Orejuela L, et al. Short report: Murine typhus in Caldas, Colombia. Am J Trop Med Hyg. 2008;78:321-2. https://doi.org/10.4269/ajtmh.2008.78.321
Ramírez-Hernández A, Montoya V, Martínez A, Pérez JE, Mercado M, de la Ossa A, et al. Molecular detection of Rickettsia felis in different flea species from Caldas, Colombia. Am J Trop Med Hyg. 2013;89:453-9. https://doi.org/10.4269%2Fajtmh.12-0698
Hidalgo M, Montoya V, Martínez A, Mercado M, De la Ossa A, Vélez C, et al. Flea-borne rickettsioses in the north of Caldas province, Colombia. Vector Borne Zoonotic Dis. 2013;13:289-94. https://doi.org/10.1089/vbz.2012.1173
Colonia CB, Ramírez-Hernández A, Gil-Mora J, Agudelo JC, Castaño-Villa GJ, Pino C, et al. Flea-borne Rickettsia species in fleas, Caldas department, Colombia. J Infect Dev Ctries. 2020;14:1155-63. https://doi.org/10.3855/jidc.12524
Smithee L, Hull H, Lynch C, Parrish R. Public health reporting and national notification for spotted fever rickettsiosis (including Rocky Mountain spotted fever). Fecha de consulta: 12 de febrero de 2020. Disponible en: https://cdn.ymaws.com/www.cste.org/resource/resmgr/PS/09-ID-16.pdf
Drexler NA, Dahlgren FS, Heitman KN, Massung RF, Paddock CD, Behravesh CB. National surveillance of spotted fever group rickettsioses in the United States, 2008-2012. Am J Trop Med Hyg. 2016;94:26-34. https://doi.org/10.4269%2Fajtmh.15-0472
Valbuena G, Feng HM, Walker DH. Mechanisms of immunity against rickettsiae. New perspectives and opportunities offered by unusual intracellular parasites. Microbes Infect. 2002;4:625-33. https://doi.org/10.1016/s1286-4579(02)01581-2
Arroyave E, Londoño AF, Quintero JC, Agudelo-Flórez P, Arboleda M, Díaz FJ, et al. Etiología y caracterización epidemiológica del síndrome febril no palúdico en tres municipios del Urabá antioqueño, Colombia. Biomédica. 2013;33:99-107. https://doi.org/10.7705/biomedica.v33i0.734
Weber N, Trujill-Trujillo J, Krücken J, Michl C, Hidalgo ME, Appráez-Ippolito G, et al. Tickbite-associated chronic pruritic lesions in an Afro-descendant population in the Cauca Department, Colombia. I. Clinical features and impact on health. Int J Dermatol. 2020;59:1491-501. https://doi.org/10.1111/ijd.15184
Labruna MB, Walker DH. Rickettsia felis and changing paradigms about pathogenic rickettsiae. Emerg Infect Dis. 2014;20:1768-9. https://doi.org/10.3201/eid2010.131797
Gil-Lora E, Patiño-Gallego J, Acevedo-Gutiérrez L, Montoya-Ruiz C, Rodas-González J. Infección y enfermedad por Rickettsia Spp. del grupo de las fiebres manchadas en pacientes febriles del Urabá antioqueño, Colombia. Iatreia. 2019;32:167-76. https://doi.org/10.17533/udea.iatreia.15
Faccini-Martínez Á, Ramírez-Hernández A, Barreto C, Forero-Becerra E, Millán D, Valbuena E, et al. Epidemiology of spotted fever group rickettsioses and acute undifferentiated febrile illness in Villeta, Colombia. Am J Trop Med Hyg. 2017;97:782-8. https://doi.org/10.4269/ajtmh.16-0442
Quintero JC, Paternina LE, Uribe A, Muskus CE, Hidalgo M, Gil J, et al. Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. PLoS Negl Trop Dis. 2017;11:e0005892. https://doi.org/10.1371/journal.pntd.0005892
Bernabeu-Wittel M, Segura-Porta F. Enfermedades producidas por rickettsias. Enferm Infecc Microbiol Clin. 2005;23:163-72. https://doi.org/10.1157/13072167
Diaz J, Catano J. Fiebre manchada de las Montañas Rocosas: ni tan manchada ni tan montañosa como pensábamos. Infectio. 2010;14:264-76.
Peniche-Lara G, Dzul-Rosado KR, Zavala-Velázquez JE, Zavala-Castro J. Murine typhus: Clinical and epidemiological aspects. Colomb Med (Cali). 2012;43:175-80.
Quintero, JC, Londoño A, Díaz F, Agudelo-Flórez P, Arboleda M, et al. Ecoepidemiología de la infección por rickettsias en roedores, ectoparásitos y humanos en el noroeste de Antioquia, Colombia. Biomédica. 2013;33:38-51. https://doi.org/10.7705/biomedica.v33i0.735
Horta MC, Moraes-Filho J, Casagrande RA, Saito TB, Rosa SC, Ogrzewalska M, et al. Experimental infection of opossums Didelphis aurita by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense. Vector Borne Zoonotic Dis. 2009;9:109-18. https://doi.org/10.1089/vbz.2008.0114
Bozeman FM, Shiral A, Humphries JW, Fuller HS. Ecology of Rocky Mountain spotted fever. II. Natural infection of wild mammals and birds in Virginia and Maryland. Am J Trop Med Hyg. 1967;16:48-59.
Miranda RJ, Mattar S, González M. Rickettsiosis. Rev MVZ Córdoba. 2017;22:6118-33.
Tomassone L, Portillo A, Nováková M, de Sousa R, Oteo JA. Neglected aspects of tick-borne rickettsioses. Parasit Vectors. 2018;11:263. https://doi.org/10.1186/s13071-018-2856-y
Stewart A, Armstrong M, Graves S, Hajkowicz K. Clinical manifestations and outcomes of Rickettsia australis infection: A 15-year retrospective study of hospitalized patients. Trop Med Infect Dis. 2017;2:19. https://doi.org/10.3390/tropicalmed2020019
Londoño AF, Díaz FJ, Valbuena G, Gazi M, Labruna MB, Hidalgo M, et al. Infection of Amblyomma ovale by Rickettsia sp. strain Atlantic rainforest, Colombia. Ticks Tick Borne Dis. 2014;5:672-5. https://doi.org/10.1016/j.ttbdis.2014.04.018
Faccini-Martínez Á, Ramírez-Hernández A, Forero-Becerra E, Cortés-Vecino JA, Escandón P, Rodas JD, et al. Molecular evidence of different Rickettsia species in Villeta, Colombia. Vector Borne Zoonotic Dis. 2016;16:85-7. https://doi.org/10.1089/vbz.2015.1841
Suárez R, Hidalgo M, Niño N, González C, Vesga JF, Orejuela L, et al. Las rickettsias como agentes etiológicos de entidades febriles no diagnosticadas en Colombia. Primera edición. ogotá, D.C.: Ediciones Uniandes; 2008. p. 10.
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Funding data
-
Universidad de Caldas
Grant numbers 0766914 -
Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
Grant numbers 112765740609 -
Pontificia Universidad Javeriana
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