Candidemia en Colombia

Jorge Alberto Cortés, José Franklin Ruiz, Lizeth Natalia Melgarejo-Moreno, Elkin V. Lemos, .

Palabras clave: candidiasis, candidemia, unidad de cuidados intensivos, micosis, infecciones fúngicas invasivas, candidiasis invasiva, Colombia

Resumen

En Colombia, especialmente en las unidades de cuidados intensivos, la candidemia es una causa frecuente de infección del torrente sanguíneo y representa el 88 % de las
infecciones fúngicas en pacientes hospitalizados, con una mortalidad entre 36 y 78 %. Su incidencia en Colombia es mayor a la reportada en los países desarrollados e, incluso, en otros países de Latinoamérica. Para su manejo deben considerarse los factores de riesgo del paciente, luego valorar las características clínicas y, finalmente, hacer los estudios microbiológicos y, si es necesario, pruebas moleculares.
En general, las guías estadounidenses, latinoamericanas y europeas recomiendan las equinocandinas como el tratamiento de primera línea de la candidemia y difieren en el uso de fluconazol dependiendo de la ‘evidencia’, la gravedad de la enfermedad, la exposición previa a los azoles y la prevalencia de Candida no albicans. Dada su gran incidencia en nuestro país, asociada con una elevada mortalidad, esta infección debe buscarse sistemáticamente en pacientes con factores de riesgo, con el fin de iniciar oportunamente el tratamiento antifúngico.

 

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  • Jorge Alberto Cortés Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia; Grupo de Investigación en Enfermedades Infecciosas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia
  • José Franklin Ruiz Departamento Médico, Pfizer, Bogotá, D.C., Colombia
  • Lizeth Natalia Melgarejo-Moreno Grupo de Investigación en Enfermedades Infecciosas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia
  • Elkin V. Lemos Departamento Médico, Pfizer, Bogotá, D.C., Colombia

Citas

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Cómo citar
Cortés, J. A., Ruiz, J. F., Melgarejo-Moreno, L. N., & Lemos, E. V. (2020). Candidemia en Colombia. Biomédica, 40(1), 195-207. https://doi.org/10.7705/biomedica.4400
Publicado
2020-03-01
Sección
Revisión de tema