Evaluación de la infestación por Strongyloides stercoralis en pacientes con HTLV-1

Nilo Manoel Pereira Vieira Barreto , Marina Morena Brito Farias , Cíntia de Lima Oliveira, Weslei Almeida Costa Araujo , Maria Fernanda Rios Grassi , Joelma Nascimento de Souza , Beatriz Soares Jacobina , Márcia Cristina Aquino Teixeira, Bernardo Galvão-Castro, Neci Matos Soares, .

Palabras clave: Strongyloides stercoralis, estrongiloidiasis, virus linfotrópico T de tipo 1 humano, coinfección, helmintos

Resumen

Introducción. Los individuos infectados por el virus linfotrópico T humano tipo 1 (HTLV-1) pueden presentar formas graves y diseminadas de infestación por Strongyloides stercoralis con poca mejoría terapéutica.
Objetivo. Investigar la infestación por S. stercoralis y la seroprevalencia de IgG anti-S. stercoralis en individuos infectados por HTLV-1 atendidos en el Centro de Referencia para HTLV-1 (CHTLV), en Salvador, Bahía, Brasil.
Materiales y métodos. Se hizo un estudio transversal con 178 individuos infectados por HTLV-1 atendidos en el centro especializado de HTLV entre enero de 2014 y diciembre de 2018. El diagnóstico parasitológico de S. stercoralis se hizo mediante los métodos de Hoffman, Pons y Janer, cultivo en placa de agar y Baermann-Morais. Para la detección de IgG anti-S. stercoralis, se utilizó una prueba casera de inmunoabsorción ligada a enzimas (ELISA). La infección por HTLV-1 se diagnosticó usando un ELISA comercial y se confirmó mediante Western blot.
Resultados. La frecuencia de infestación por S. stercoralis fue del 3,4 % (6/178). Además, los individuos infestados por S. stercoralis provenientes de la zona rural (50,0 %; 3/6) también mostraron hiperinfestación por S. stercoralis (>3.000 larvas/gramo de heces). La frecuencia de anticuerpos IgG anti-S. stercoralis fue del 20,8 % (37/178).
Conclusiones. Las personas infectadas por HTLV-1 que viven en condiciones sanitarias precarias son más propensas a desarrollar formas graves de infestación por S. stercoralis. Teniendo en cuenta la gran vulnerabilidad y el resultado desfavorable de la infección en estos individuos, se debe considerar el diagnóstico serológico de S. stercoralis para administrar el tratamiento.

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  • Nilo Manoel Pereira Vieira Barreto Instituto de Ciências da Saúde, Programa de Pós-graduação em Processos Interativos dos Órgãos e Sistemas, Universidade Federal da Bahia, Bahia, Brasil
  • Marina Morena Brito Farias Instituto de Ciências da Saúde, Programa de Pós-graduação em Processos Interativos dos Órgãos e Sistemas, Universidade Federal da Bahia, Bahia, Brasil
  • Cíntia de Lima Oliveira Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Weslei Almeida Costa Araujo Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Maria Fernanda Rios Grassi Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Bahia, Brasil
  • Joelma Nascimento de Souza Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Beatriz Soares Jacobina Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil
  • Márcia Cristina Aquino Teixeira Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil
  • Bernardo Galvão-Castro Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil
  • Neci Matos Soares Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil

Referencias bibliográficas

Bisoffi Z, Buonfrate D, Montresor A, Requena-Méndez A, Muñoz J, Krolewiecki AJ, et al. Strongyloides stercoralis: A plea for action. PLoS Negl Trop Dis. 2013;7:e2214. https://doi.org/10.1371/journal.pntd.0002214

Nutman TB. Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology. 2017;144:263-73. https://doi.org/10.1017/S0031182016000834

World Health Organization. Soil-transmitted helminth infections. Date of access: October 13, 2020. Available from: https://www.who.int/news-room/fact-sheets/detail/soil-transmittedhelminth-infections

Devi U, Borkakoty B, Mahanta J. Strongyloidiasis in Assam, India: A community-based study. Trop Parasitol. 2011;1:30-2. https://doi.org/10.4103/2229-5070.72110

Schär F, Trostdorf U, Giardina F, Khieu V, Muth S, Marti H, et al. Strongyloides stercoralis: Global distribution and risk factors. PLoS Negl Trop Dis. 2013;7:e2288. https://doi.org/10.1371/journal.pntd.0002288

Paula FM, Costa-Cruz JM. Epidemiological aspects of strongyloidiasis in Brazil. Parasitology. 2011;138:1331-40. https://doi.org/10.1017/S003118201100120X

Santos LP, Santos FLN, Soares NM. Prevalência de parasitoses intestinais em pacientes atendidos no Hospital Universitário Professor Edgar Santos, Salvador-Bahia. Rev Patol Trop J Trop Pathol. 2007;36:237-46. https://doi.org/10.5216/rpt.v36i3.3180

Inês E de J, Souza JN, Santos RC, Souza ES, Santos FL, Silva MLS, et al. Efficacy of parasitological methods for the diagnosis of Strongyloides stercoralis and hookworm in faecal specimens. Acta Trop. 2011;120:206-10. https://doi.org/10.1016/j.actatropica.2011.08.010

Carvalho EM, Da Fonseca Porto A. Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis. Parasite Immunol. 2004;26:487-97. https://doi.org/10.1111/j.0141-9838.2004.00726.x

Shorman M, Al-Tawfiq JA. Strongyloides stercoralis hyperinfection presenting as acute respiratory failure and Gram-negative sepsis in a patient with astrocytoma. Int J Infect Dis. 2009;13:e288-91. https://doi.org/10.1016/j.ijid.2008:11.019

Buonfrate D, Requena-Méndez A, Angheben A, Muñoz J, Gobbi F, Van Den Ende J, et al. Severe strongyloidiasis: A systematic review of case reports. BMC Infect Dis. 2013;13:78. https://doi.org/10.1186/1471-2334-13-78

Hirata T, Uchima N, Kishimoto K, Zaha O, Kinjo N, Hokama A, et al. Impairment of host immune response against strongyloides stercoralis by human T cell lymphotropic virus type 1 infection. Am J Trop Med Hyg. 2006;74:246-9. https://doi.org/10.4269/ajtmh.2006.74.246

de Souza JN, Soares BNRR, Goes LL, Lima C de S, Barreto NMPV, Jacobina BS, et al. Case report: Strongyloides stercoralis hyperinfection in a patient with HTLV-1: An infection with filariform and rhabditiform larvae, eggs, and free-living adult females output. Am J Trop Med Hyg. 2018;99:1583-6. https://doi.org/10.4269/ajtmh.18-0402

Gessain A, Mahieux R. Tropical spastic paraparesis and HTLV-1 associated myelopathy: Clinical, epidemiological, virological and therapeutic aspects. Rev Neurol (Paris). 2012;168:257-69. https://doi.org/10.1016/j.neurol.2011.12.006

Gessain A, Cassar O. Epidemiological aspects and world distribution of HTLV-1 infection. Front Microbiol. 2012;3:388. https://doi.org/10.3389/fmicb.2012.00388

Galvão-Castro B, Loures L, Rodriques LG, Sereno A, Ferreira Júnior OC, Franco LG, et al. Distribution of human T-lymphotropic virus type I among blood donors: A nationwide Brazilian study. Transfusion (Paris). 1997;37:242-3. https://doi.org/10.1046/j.1537-2995.1997.37297203532.x

Dourado I, Alcantara LCJ, Barreto ML, Teixeira M da G, Castro Filho BG. HTLV-I in the general population of Salvador, Brazil: A city with African ethnic and sociodemographic characteristics. J Acquir Immune Defic Syndr. 2003;34:527-31. https://doi.org/10.1097/00126334-200312150-00013

Hayashi J, Kishihara Y, Yoshimura E, Furusyo N, Yamaji K, Kawakami Y, et al. Correlation between human T cell lymphotropic virus type-1 and Strongyloides stercoralis infections and serum immunoglobulin E responses in residents of Okinawa, Japan. Am J Trop Med Hyg. 1997;56:71-5. https://doi.org/10.4269/ajtmh.1997.56.71

Catalan-Soares BC, Proietti FA, Carneiro-Proietti AB de F. Os vírus linfotrópicos de células T humanos (HTLV) na última década (1990-2000): aspectos epidemiológicos. Rev Bras Epidemiol. 2001;4:81-95. https://doi.org/10.1590/S1415-790X2001000200003

Chieffi PP, Chiattone CS, Feltrim EN, Alves RC, Paschoalotti MA. Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in São Paulo city, Brazil. Mem Inst Oswaldo Cruz. 2000;95:711-2. https://doi.org/10.1590/S0074-02762000000500017

Furtado KCYO, Costa CA da, Ferreira L de SC, Martins LC, Linhares A da C, Ishikawa EAY, et al. Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil. Rev Soc Bras Med Trop. 2013;46:241-3. https://doi.org/10.1590/0037-8682-981-2013

Rosadas C, Taylor GP. Mother-to-child HTLV-1 transmission: Unmet research needs. Front Microbiol. 2019;10:999. https://doi.org/10.3389/fmicb.2019.00999

Proietti FA, Carneiro-Proietti ABF, Catalan-Soares BC, Murphy EL. Global epidemiology of HTLV-I infection and associated diseases. Oncogene. 2005;24:6058-68. https://doi.org/10.1038/sj.onc.1208968

Romanelli LCF, Caramelli P, Proietti AB de FC. O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção? Rev Assoc Médica Bras. 2010;56:340-7. https://doi.org/10.1590/S0104-42302010000300021

Hoffman WA, Pons JA, Janer JL. The sedimentation-concentration method in Schistosomiasis mansoni. Puerto Rico Journal of Public Health and Tropical Medicine. 1934;9:283-8.

Moraes R. Contribuiçao para o estudo do Strongyloides stercoralis e da estrongiloidiase no Brasil. Rev Serv Espec Saúde Pública. 1948;1:507-624.

Rugai E, Mattos T, Brisola AP. A new technique for the isolation of nematode larvae from feces; modification of Baermann’s method. Rev Inst Adolfo Lutz. 1954;14:5-8.

Arakaki T, Hasegawa H, Asato R, Ikeshiro T, Kinjo F, Saito A, et al. A new method to detect Strongyloides stercoralis from human stool. Japan J Trop Med Hyg 1988;16:11-7. https://doi.org/10.2149/tmh1973.16.11

Inês E de J, Silva MLS, Souza JN, Teixeira MCA, Soares NM. The role of glycosylated epitopes in the serodiagnosis of Strongyloides stercoralis infection. Diagn Microbiol Infect Dis. 2013;76:31-5. https://doi.org/10.1016/j.diagmicrobio.2013.01.016

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-75. https://doi.org/10.1016/S0021-9258(19)52451-6

Maxwell SE, Delaney HD, Kelley K. Designing experiments and analyzing data: A model comparison perspective. 3rd edition. New York, NY: Routledge; 2017.

Ludwig DA. Use and misuse of p-values in designed and observational studies: Guide for researchers and reviewers. Aviat Space Environ Med. 2005;76:675-80.

Nakada K, Kohakura M, Komoda H, Hinuma Y. High incidence of HTLV antibody in carriers of Strongyloides stercoralis. Lancet Lond Engl. 1984;1:633. https://doi.org/10.1016/s0140-6736(84)91030-4

Nakada K, Yamaguchi K, Furugen S, Nakasone T, Nakasone K, Oshiro Y, et al. Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. Int J Cancer. 1987;40:145-8. https://doi.org/10.1002/ijc.2910400203

Tanaka T, Hirata T, Parrott G, Higashiarakawa M, Kinjo T, Kinjo T, et al. Relationship among Strongyloides stercoralis infection, human T-Cell lymphotropic virus type 1 infection, and cancer: A 24-year cohort inpatient study in Okinawa, Japan. Am J Trop Med Hyg. 2016;94:365-70. https://doi.org/10.4269/ajtmh.15-0556

Gillet NA, Cook L, Laydon DJ, Hlela C, Verdonck K, Álvarez C, et al. Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. PLoS Pathog. 2013;9:e1003263. https://doi.org/10.1371/journal.ppat.1003263

G/hiwot Y, Degarege A, Erko B. Prevalence of intestinal parasitic infections among children under five years of age with emphasis on Schistosoma mansoni in Wonji Shoa Sugar Estate, Ethiopia. PloS ONE. 2014;9:e109793. https://doi.org/10.1371/journal.pone.0109793

Alemu M, Anley A, Tedla K. Magnitude of intestinal parasitosis and associated factors in rural school children, Northwest Ethiopia. Ethiop J Health Sci. 2019;29:923-8. https://doi.org/10.4314/ejhs.v29i1.14

Kuleš J, Potocnakova L, Bhide K, Tomassone L, Fuehrer H-P, Horvatić A, et al. The challenges and advances in diagnosis of vector-borne diseases: Where do we stand? Vector Borne Zoonotic Dis Larchmt N. 2017;17:285-96. https://doi.org/10.1089/vbz.2016.2074

Ray S, Meena RK. Larva migrans in children in India - Is it as rare as we think? Pediatr Oncall. 2017;14:1-4. https://doi.org/10.7199/ped.oncall.2017.35

de Souza JN, Inês EDJ, Santiago M, Teixeira MCA, Soares NM. Strongyloides stercoralis infection in patients with systemic lupus erythematosus: Diagnosis and prevention of severe strongyloidiasis. Int J Rheum Dis. 2016;19:700-5. https://doi.org/10.1111/1756-185X.12644

Silva MLS, Inês E de J, Souza AB da S, Dias VM dos S, Guimarães CM, Menezes ER, et al. Association between Strongyloides stercoralis infection and cortisol secretion in alcoholic patients. Acta Trop. 2016;154:133-8. https://doi.org/10.1016/j.actatropica.2015.11.010

Montes M, Sánchez C, Verdonck K, Lake JE, González E, López G, et al. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis.2009;3:e456. https://doi.org/10.1371/journal.pntd.0000456

Pays J-F. Combined infection with HTLV-1 and Strongyloides stercoralis. Bull Soc Pathol Exot. 2011;104:188-99. https://doi.org/10.1007/s13149-011-0175-z

Janssen S, Rossatanga EG, Jurriaans S, ten Berge IJM, Grobusch MP. Triple infection with HIV-1, HTLV-1 and Strongyloides stercoralis, rendering CD4+ T-cell counts a misleading entity. Antivir Ther. 2013;18:949-51. https://doi.org/10.3851/IMP2692

Walker JA, McKenzie ANJ. TH 2 cell development and function. Nat Rev Immunol. 2018;18:121-33. https://doi.org/10.1038/nri.2017.118

Cómo citar
1.
Pereira Vieira Barreto NM, Brito Farias MM, Oliveira C de L, Almeida Costa Araujo W, Rios Grassi MF, Nascimento de Souza J, Soares Jacobina B, Aquino Teixeira MC, Galvão-Castro B, Matos Soares N. Evaluación de la infestación por Strongyloides stercoralis en pacientes con HTLV-1. biomedica [Internet]. 1 de marzo de 2022 [citado 17 de mayo de 2022];42(1):31-0. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/5888

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2022-03-01
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