Expresion of the multiple drug resistance associated gene (pfMDR 1) in Colombian strains of Plasmodium falciparum
Keywords:
plasmodium, malaria, resistance, drugs, MDR-gene
Abstract
The treatment and control of malaria have confronted obstacles dueto the parasite's capacity to develop resistance to antimalarial agents. Chloroquine, which has been the main agent against malaria due to its efficiency, low toxicity and cost, is now failing in the control of the disease.The mechanism through which the parasite develops resistance to chloroquine has not been defined yet, although the amplification, over-expression and point mutationsfound in a gene called pfmdrl (Plasmodium falciparummultidrug resistance gene) were related to the chloroquine resistance phenotype (CQR). Nevertheless, later studies opened controversial discussion over such association.The present research work studied pfmdrl gene's expression in Colombian strains of P falciparum and in two reference strains: a sensitive one (Haiti 135) and a resistant one (Palo Alto), using a slot-blot test. The results obtained allow us to suggest that the pfmdrl gene's expression is not directly reiated to the resistant phenotype.Downloads
Download data is not yet available.
How to Cite
1.
Calvo EP, Rojas MO, Chaparro J, Wasserman M. Expresion of the multiple drug resistance associated gene (pfMDR 1) in Colombian strains of Plasmodium falciparum. biomedica [Internet]. 1999 Sep. 1 [cited 2024 May 16];19(3):198-206. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1023
Some similar items:
- Iveth J. González, Metacaspases and their role in the life cycle of human protozoan parasites , Biomedica: Vol. 29 No. 3 (2009)
- Carolina Montoya, Priscila Bascuñán, Julián Rodríguez-Zabala, Margarita M. Correa, Abundance, composition and natural infection of Anopheles mosquitoes from two malaria-endemic regions of Colombia , Biomedica: Vol. 37 No. Sup. 2 (2017): Suplemento 2, Entomología médica, 2017
- César Segura, Silvia Blair, Mitochondria in the Plasmodium genera. , Biomedica: Vol. 23 No. 3 (2003)
- Pablo Chaparro, Edison Soto, Julio Padilla, Daniel Vargas, Estimation of the underreporting of malaria measurement in ten municipalities of the Pacific coast of Nariño during 2009 , Biomedica: Vol. 32 (2012): Suplemento 1, Malaria
- Rosa Magdalena Uscátegui, Adriana M. Correa, Jaime Carmona-Fonseca, Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria , Biomedica: Vol. 29 No. 2 (2009)
- Ana María Vásquez, Felipe Sanín, Luis Gonzalo Álvarez, Alberto Tobón, Alexandra Ríos, Silvia Blair, Therapeutic efficacy of a regimen of artesunate-mefloquine-primaquine treatment for Plasmodium falciparum malaria and treatment effects on gametocytic development , Biomedica: Vol. 29 No. 2 (2009)
- Julio Sandoval-Bances , Milagros Saavedra-Samillán , Sonia Huyhua-Gutiérrez , Luis M. Rojas , Sonia Tejada-Muñoz , Rafael Tapia-Limonchi , Stella M. Chenet , Molecular characterization of the Plasmodium falciparum k13 gene helix domain in samples from native communities of Condorcanqui, Amazonas, Perú , Biomedica: Vol. 43 No. 3 (2023)
- Juan Gabriel Piñeros, Margarita Arboleda, Juan Camilo Jaramillo, Silvia Blair, Report of five cases of severe neonatal Plasmodium vivax malaria in Urabá, Colombia , Biomedica: Vol. 28 No. 4 (2008)
- Amanda Maestre, Jaime Carmona-Fonseca, Amanda Maestre, Alta frecuencia de mutaciones puntuales en pfcrt de Plasmodium falciparum y emergencia de nuevos haplotipos mutantes en Colombia , Biomedica: Vol. 28 No. 4 (2008)
- Jaime Carmona-Fonseca, Eliana Arango, Silvia Blair, Gametocytemia in falciparum malaria treated with amodiaquine or artesunate , Biomedica: Vol. 28 No. 2 (2008)
Published
1999-09-01
Issue
Section
Original articles
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
