Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention.
Keywords:
Mycobacterium tuberculosis, gene inactivation, functional genomic, attenuated mutants
Abstract
Availability of the M. tuberculosis genome sequence and the development of sophisticated systems for genetic manipulation of bacilli offer the potential for new and effective tools to prevent and control tuberculosis. Efficient methods to inactivate mycobacterial genes have been developed. These methods have become the cornerstone for the application and development of mycobacterial functional genomics. Specific mutants are generated to establish the role of targetted genes associated with mycobacterial physiology and pathogenesis. Gene inactivation, supported directly or indirectly by the deciphering of the mycobacterial genome, has permitted the generation of large numbers of M. tuberculosis mutants. Analysis of these mutants has (in some cases) established relationships between gene products and their role in mycobacterial physiology and pathogenesis.Downloads
Download data is not yet available.
How to Cite
1.
Chacón O, Realpe T, Barletta RG, Robledo J. Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention. Biomed. [Internet]. 2004 Jun. 1 [cited 2024 Aug. 18];24(Sup1):165-87. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1316
Some similar items:
- Juan Gabriel Bueno-Sánchez, Jairo René Martínez-Morales, Elena E. Stashenko, Wellman Ribón, Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia , Biomedica: Vol. 29 No. 1 (2009)
- María Consuelo Garzón, Dailyn Yorledy Angée, Claudia Llerena, Dora Leticia Orjuela, Jorge Ernesto Victoria, Surveillance of Mycobacterium tuberculosis resistance to antituberculosis drugs , Biomedica: Vol. 28 No. 3 (2008)
- Wellman Ribón, Claudia Castro, Liliana González, Juan Carlos Rozo, Gloria Puerto, Biosafety evaluation of the DNA extraction protocol for Mycobacterium tuberculosis complex species, as implemented at the Instituto Nacional de Salud, Colombia , Biomedica: Vol. 29 No. 4 (2009)
- Leandro Galvis, Ángel Y. Sánchez, Leonardo F. Jurado, Martha I. Murcia, Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia , Biomedica: Vol. 38 No. 1 (2018)
- Diego Chaves, Andrea Sandoval, Luis Rodríguez, Juan C. García, Silvia Restrepo, María Mercedes Zambrano, Comparative analysis of six Mycobacterium tuberculosis complex genomes , Biomedica: Vol. 30 No. 1 (2010)
- Flor de María Cáceres, Luis Carlos Orozco, Incidence of and factors for non-compliance to antituberculous treatment , Biomedica: Vol. 27 No. 4 (2007)
- Diana Castaño, Mauricio Rojas, Alterations in recruitment and activation of Rab proteins during mycobacterial infection , Biomedica: Vol. 30 No. 2 (2010)
- Claudia Llerena, Santiago Elías Fadul, María Consuelo Garzón, Graciela Mejía, Dora Leticia Orjuela, Luz Mary García, Hilda Beatriz Álvarez, Fernando Javier Ruiz, Drug-resistant Mycobacterium tuberculosis in children under 15 years , Biomedica: Vol. 30 No. 3 (2010)
- Constanza Collazos, Gabriel Carrasquilla, Milcíades Ibáñez, Lilia Edith López, Prevalence of respiratory symptomatic in health institutions of Bogotá, Colombia , Biomedica: Vol. 30 No. 4 (2010)
- Marcela López, Claudia Álvarez, Utility of nitrate reductase assay for detection of multidrug-resistant Mycobacterium tuberculosis in a low resource setting , Biomedica: Vol. 31 No. 2 (2011)
Published
2004-06-01
Section
Topic review
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |