Evaluation of PANBIO rapid immunochromatographic cassette for dengue diagnosis in a Colombian endemic area
Keywords:
Dengue/diagnosis, diagnostic techniques and procedures, sensitivity and specificity, reproducibility of results.
Abstract
Introduction. Traditional tests for dengue diagnosis are not useful during the first days of disease onset, because they require time and complex techniques or because they have low sensitivity.Objective. The reliability and precisison was determined for the rapid test in cassette (PANBIO) for dengue diagnosis in acute and convalescent serum samples.
Materials and methods. The immunochromatographic test was evaluated in samples from patients older than 5 years with acute febrile syndrome. The patients came from the metropolitan area of Bucaramanga during April and August of 2003. Acute and convalescent serum came from 67 dengue cases, diagnosed by viral isolation or IgM paired tests (modified MAC-ELISA), and from 33 patients with acute febrile syndrome (not dengue) that served as controls.
Results. Reliability was good (kappa=0.84). In the convalescent serum, the test showed sensitivity of 76.1%, specificity of 75.8%, positive predictive value of 86.4% and negative predictive value of 61.0%, positive likelihood ratio 3.14 and negative likelihood ratio 0.32. In the acute phase, the values were 52.2%, 84.8%, 87.5%, 46.7%, 3.45 and 0.56, respectively.
Conclusions. Rapid immunochromatographic test for dengue diagnosis shows good reproducibility and specificity, with an acceptable sensitivity. Therefore, this rapid test is recommended as diagnostic tool in endemic areas.
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References
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21. Lam SK, Devine PL. Evaluation of capture ELISA and rapid immunochromatographic test for the determination of IgM and IgG antibodies produced during dengue infection. Clin Diagn Virol. 1998;10:75-81.
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24. Díaz-Quijano FA, Martínez RA, Ocazionez RE, Villar-Centeno LA. Evaluación de la prueba de IgM en suero agudo para el diagnóstico del dengue en un área endémica. Enferm Infecc Microbiol Clin. 2006;24:90-2.
25.Schilling S, Ludolfs D, van An L, Schmitz H. Laboratory diagnosis of primary and secondary dengue infection. J Clin Virol. 2004;31:179-84.
26. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue in the early febrile phase: viremia and antibody responses.J Infect Dis. 1997;176:322-30.
27. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:2-9.
28. Fagan TJ. Letter. Nomogram for Bayes theorem. N Engl J Med. 1975;293:257.
2. Pan American Health Organization, World Health Organization. 2008: Number of reported cases of dengue and dengue hemorrhagic fever (DHF), region of the Americas (by country and subregion). Figures for 2008 (to week noted by each country). Epidemiological Week/EW 53. Update: January 27, 2009. Fecha de consulta: febrero de 2009. Disponible en:http://www.paho.org/english/ad/dpc/cd/dengue-cases-2008.htm
3. Ministerio de la Protección Social, Instituto Nacional de Salud. Enfermedades de notificación obligatoria. Informe primer semestre de 2003. Sistema de Vigilancia en Salud Pública. Boletín Epidemiológico Semanal. Semana epidemiológica No. 26. Junio 22-28 de 2003. Fecha de consulta: febrero 2009. Disponible en:www.col.ops-oms.org/sivigila/2003/BOLE26_03.pdf
4. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11:480-96.
5. Chairulfatah A, Setiabudi D, Ridad A, Colebunders R. Clinical manifestations of dengue haemorrhagic fever in children in Bandung, Indonesia. Ann Soc Belg Med Trop. 1995;75:291-5.
6. Harris E, Pérez L, Phares C, Pérez M, Idiaquez W, Rocha J, et al. Fluid intake and decreased risk for hospitalization dengue fever, Nicaragua. Emerg Infect Dis. 2003;9:1003-6.
7. Díaz-Quijano FA, Villar-Centeno LA, Martínez-Vega. Efecto de la administración de dipirona sobre la gravedad del dengue en una cohorte prospectiva. Enferm Infecc Microbiol Clin. 2005;23:593-7.
8. Martínez-Vega RA, Díaz-Quijano FA, Villar Centeno LA. Dificultad para el diagnóstico clínico temprano del dengue en un área endémica y su impacto sobre el manejo médico inicial. Rev Med Chile. 2006;134:1153-60.
9. Levett PN, Branch SL, Edwards CN. Detection of dengue infection in patients investigated for leptospirosis in Barbados. Am J Trop Med Hyg. 2000;62:112-4.
10. Watt G, Jongsakul K, Chouriyagune C, Paris R. Differentiating dengue virus infection from scrub typhus in Thai adults with fever. Am J Trop Med Hyg. 2003;68:536-8.
11. Seijo A, Cernigoi B, Deodato B. Dengue importado de Paraguay a Buenos Aires. Reporte clínico y epidemiológico de 38 casos. Medicina (Buenos Aires). 2001;61:137-41.
12. Pan American Health Organization. Dengue and dengue hemorrhagic fever in the Americas: guidelines for prevention and control. Scientific Publication No. 548. Washington, D.C.: PAHO; 1994. p. 3-22.
13. Dietz VJ, Gubler DJ, Rigau-Perez JG, Pinheiro F, Schatzmayr HG, Bailey R, et al. Epidemic dengue 1 in Brazil, 1986: evaluation of a clinically based dengue surveillance system. Am J Epidemiol. 1990;131:693-701.
14. Endy T, Chunsuttiwat S, Nisalak A, Libraty D, Green S, Rothman A, et al. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002;156:40-50.
15. Cuzzubbo AJ, Endy TP, Nisalak A, Kalayanarooj S, Vaughn DW, Ogata SA, et al. Use of recombinant envelope proteins for serological diagnosis of dengue virus infection in an immunochromatographic assay. Clin Diagn Lab Immunol. 2001;8:1150-5.
16. Groen J, Koraka P, Velzing J, Copra C, Osterhaus AD. Evaluation of six immunoassays for detection of dengue virus-specific immunoglobulin M and G antibodies. Clin Diagn Lab Immunol. 2000;7:867-71.
17. Wu SJ, Paxton H, Hanson B, Kung CG, Chen TB, Rossi C, et al. Comparison of two rapid diagnostic assays for detection of immunoglobulin M antibodies to dengue virus. Clin Diagn Lab Immunol. 2000;7:106-10.
18. Porter KR, Widjaja S, Lohita HD, Hadiwijaya SH, Maroef CN, Suharyono W, et al. Evaluation of a commercially available immunoglobulin M capture enzyme-linked immunosorbent assay kit for diagnosing acute dengue infections.Clin Diagn Lab Immunol. 1999;6:741-4.
19. Branch SL, Levett PN. Evaluation of four methods for detection of immunoglobulin M antibodies to dengue virus. Clin Diagn Lab Immunol. 1999;6:555-7.
20. Palmer CJ, King SD, Cuadrado RR, Perez E, Baum M, Ager AL. Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid immunochromatographic test for diagnosis of dengue fever in Jamaica. J Clin Microbiol. 1999;37:1600-1.
21. Lam SK, Devine PL. Evaluation of capture ELISA and rapid immunochromatographic test for the determination of IgM and IgG antibodies produced during dengue infection. Clin Diagn Virol. 1998;10:75-81.
22. Blacksell SD, Doust JA, Newton PN, Peacock SJ, Day NP, Dondorp AM. A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Trans R Soc Trop Med Hyg. 2006;100:775-84.
23. Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, et al. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg. 1989;40:418-27.
24. Díaz-Quijano FA, Martínez RA, Ocazionez RE, Villar-Centeno LA. Evaluación de la prueba de IgM en suero agudo para el diagnóstico del dengue en un área endémica. Enferm Infecc Microbiol Clin. 2006;24:90-2.
25.Schilling S, Ludolfs D, van An L, Schmitz H. Laboratory diagnosis of primary and secondary dengue infection. J Clin Virol. 2004;31:179-84.
26. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue in the early febrile phase: viremia and antibody responses.J Infect Dis. 1997;176:322-30.
27. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:2-9.
28. Fagan TJ. Letter. Nomogram for Bayes theorem. N Engl J Med. 1975;293:257.
How to Cite
1.
Martínez-Vega RA, Díaz Quijano FA, Coronel Ruiz C, Gómez SY, Villar Centeno L Ángel. Evaluation of PANBIO rapid immunochromatographic cassette for dengue diagnosis in a Colombian endemic area. biomedica [Internet]. 2009 Dec. 1 [cited 2024 May 18];29(4):616-24. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/139
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2009-12-01
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