Early atherosclerotic lesions and post-mortem serum cholesterol level in a group of Colombian children
Abstract
Introduction: Atherosclerosis is an asymptomatic chronic disease, which begins at early age and is difficult to detect during this stage. Prospective studies suggest a causal relationship between total serum cholesterol levels during childhood and early adolescence and the development of cardiovascular diseases in adulthood.
Objective: The aim of this study was to evaluate the prevalence of early atherosclerotic lesions in the aorta artery of children and its relationship with post-mortem serum cholesterol levels.
Material and methods: Post-mortem samples of blood and aorta were taken from 43 subjects aged less than 17 years old. Histopathological analysis (intimal thickening and inflammatory infiltrates) of thethoracic aorta and measurement of total serum cholesterol were performed.
Results: The analysis showed thickening of the intima and lymphocyte infiltrates in 93% of children, and macrophage infiltrates in 79.1% of cases. A relationship between the highest terciles of total serum cholesterol levels and the presence of multiple lesions in the aorta wall was found (P<0.05).
Conclusion: This group of children had a high prevalence of early inflammatory atherosclerotic lesions positively related with serum cholesterol levels. To our knowledge this study represents the first reportof a relationship between post-mortem total serum cholesterol levels and pathological findings of macrophages and lymphocytes infiltrates in the aorta wall.
doi: http://dx.doi.org/10.7705/biomedica.v33i3.1443
Downloads
Some similar items:
- Nelsy Loango, Martha Lucía Gallego, Beatriz Restrepo, Patricia Landázuri, Gender, age and plasma lipids differences associated with apolipoprotein E polymorphism in school children , Biomedica: Vol. 29 No. 3 (2009)
- Elpidia Poveda, Ney Callas, César Baracaldo, Carlina Castillo, Patricia Hernández, Martha Guerra, Lipid and apoprotein A-I and B-100 levels in school children school from five central-eastern provinces of Colombia , Biomedica: Vol. 27 No. 3 (2007)
- Ney Callas, Elpidia Poveda, César Baracaldo, Patricia Hernández, Carlina Castillo, Martha Guerra, Genetic polymorphism of the E apolipoprotein in school age children: comparison with levels of plasma lipids and apolipoproteins , Biomedica: Vol. 27 No. 4 (2007)
- Ana Lucía Lópe, Juan David Vélez , Angélica María García , Elkin Fernando Arango, Concurrent validity of five prediction equations to evaluate fat percentage in a sports group expected to yield high performance from Medellín, Colombia , Biomedica: Vol. 41 No. 1 (2021)
- Andrés Leonardo González, Ruth Aralí Martínez, Luis Ángel Villar, Clinical evolution of dengue in hospitalized patients , Biomedica: Vol. 28 No. 4 (2008)
- Rubén Gómez, Cristina Fleitas, Carlos Teja, Miguel Carrascosa, Xavier Arrastio, Isabel Celemín, Penetrating atherosclerotic ulcer of the aortic arch , Biomedica: Vol. 28 No. 3 (2008)
- Ana Cecilia Aguilar, Alberto Pradilla, Mildrey Mosquera, Ana Beatriz Gracia, José Guillermo Ortega, Jaime Humberto Leiva, Robinson Ramírez-Vélez, Percentile values for physical condition for Cali, Colombian children and adolescents , Biomedica: Vol. 31 No. 2 (2011)
- Darío Echeverry, Félix R. Montes, Alexandra Delgadillo, Marcela Beltrán, Lorena Buitrago, In vitro effect of caffeine on internal mammary artery rings used in cardiac revascularization surgery , Biomedica: Vol. 28 No. 2 (2008)
- Sandra Piñeros-Ortiz, Jaime Moreno-Chaparro, Nathaly Garzón-Orjuela, Zulma Urrego-Mendoza, Daniel Samacá-Samacá, Javier Eslava-Schmalbach, Mental health consequences of armed conflicts in children and adolescents: An overview of literature reviews , Biomedica: Vol. 41 No. 3 (2021)
- Elpidia Poveda, Ney E. Callas, César M. Baracaldo, Carlina Castillo, Patricia Hernández, Leptin levels in school age children associated with anthropometric measurements and lipid profiles , Biomedica: Vol. 27 No. 4 (2007)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |