Evaluation of atypical semen parameters in individuals whose couples had a history of early recurrent embryo death: in search for a reference value
Keywords:
Spermatozoa, spontaneous abortion, oxidative stress, chromatin, antioxidants, fertility.
Abstract
Introduction. Previous studies related alterations in non-conventional seminal parameters with recurrent early embryonic death for one couple. A reference standard of clinical assessment is required for the management of these kinds of patients.Objective. Normal semen parameters were established based on functional tests including lipid peroxidation of sperm membranes, antioxidant capacity of seminal plasma and integrity of sperm chromatin to compare with men whose partners have recurrent early embryonic death. These parameters set reference values to identify subfertile individuals whose condition can be attributed to altered semen parameters.
Materials and methods. The conventional and non-conventional semen parameters of 47 samples of semen were evaluated. Thirty-six samples were from subfertile individuals whose partners had a history of early recurrent embryo death, and 11 samples were from individuals with recent evidence of normal fertility.
Results. By discriminant analysis, the two groups were classified as follows: a value below 0.50 for 86.1% of individuals in the group of recurrent early embryonic death, and a value above 0.50 to classify 81.8% of individuals in the group of recent fertility.
Conclusions. This reference value of 0.5 based on the results of sperm tests can identify infertile male patients whose partners have a history of early embryonic death. This will aid the physician to suggest treatments more focused on the possible cause of subfertility.
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References
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2. Evenson DP, Jost LK, Marshall D, Zinaman MJ, Clegg E, Purvis K, et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod. 1999;14:1039-49.
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11. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod. 1999;14:2801-7.
12. Gil-Villa AM, Cardona-Maya W, Agarwal A, Sharma R, Cadavid A. Role of male factor in early recurrent embryo loss: Do antioxidants have any effect? Fertil Steril. 2009;92:565-71.
13. Gil-Villa AM, Cardona-Maya WD, Agarwal A, Sharma R, Cadavid AP. Assesment of sperm factors possibly involved in early recurrent pregnancy loss. Fertil Steril. 2010;94:1465-72.
14. Gil-Villa A, Cardona-Maya W, Cadavid A. Muerte embrionaria temprana: ¿tiene influencia el factor masculino? Arch Esp Urol. 2007;60:1057-68.
15. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge, U.K.: Cambridge University Press; 1999.
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17. Departamento de Estadística. Universidad Carlos III de Madrid. Análisis Discriminante. Última Actualización Junio 2009. Fecha de consulta: junio de 2009. Disponible en: http://halweb.uc3m.es/esp/Personal/personas/jmmarin/esp/AMult/tema6am.pdf.
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19. Chi HJ, Kim JH, Ryu CS, Lee JY, Park JS, Chung DY, et al. Protective effect of antioxidant supplementation in sperm-preparation medium against oxidative stress in human spermatozoa. Hum Reprod. 2008;23:1023-8.
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21. Lopes S, Jurisicova A, Sun Jg, Casper RF. reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum Reprod. 1998;13:896-900.
22. Potts RJ, Notarianni LJ, Jefferies TM. Seminal plasma reduces exogenous oxidative damage to human sperm, determined by the measurement of DNA strand breaks and lipid peroxidation. Mutat Res. 2000;447:249-56.
23. Agarwal A, Said TM. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update. 2003;9:331-45.
24. Shamsi MB, Kumar R, Dada R. Evaluation of nuclear DNA damage in human spermatozoa in men opting for assisted reproduction. Indian J Med Res. 2008;127:115-23.
25. Carrell DT, Liu L, Peterson CM, Jones KP, Hatasaka HH, Erickson L, et al. Sperm DNA fargmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl. 2003;49:49-55.
26. Khosrowbeygi A, Zarghami N. Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters. BMC Clin Pathol. 2007;7:6.
27. Twigg J, Fulton, N, Gómez E, Irvine DS, Aitken RJ. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: Lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Hum Reprod. 1998;13:1429-36.
28. Keskes-Ammar L, Feki-Chakroun N, Rebai T, Sahnoun Z, Ghozzi H, Hammami S, et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl. 2003;49:83-94.
2. Evenson DP, Jost LK, Marshall D, Zinaman MJ, Clegg E, Purvis K, et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod. 1999;14:1039-49.
3. Agarwal A, Makker K, Sharma R, Ashok Agarwal. Clinical relevance of oxidative stress in male factor infertility: An update. Am J Reprod Immunol. 2008;59:2-11.
4. Koca Y, Ozdal OL, Celik M, Unal S, Balaban NY. Antioxidant activity of seminal plasma in fertile and infertile men. Arch Androl. 2003;49:355-9.
5. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod. 1989;41:183-97.
6. Agarwal A. Significance of oxidative stress and sperm chromatin damage in male infertility. In: De Vriese S. Christophe A, editors. Male fertility and lipid metabolism. Champaign, IL: AOCS Press; 2003. p.157.
7. Rubio C, Simon C, Blanco J, Vidal F, Minguez Y, Egozcue J, et al. Implications of sperm chromosome abnormalities in recurrent miscarriage. J Assist Reprod Genet. 1999;16:253-8.
8. Godpalkrishnam K, Padwal V, Mejherji PK, Gokral JS, Shan R, Juneja HS. Poor quality of sperm as it affects repeated early pregnancy loss. Arch Androl. 2000;45:111-7.
9. Bernardini LM, Costa M, Botazzi C, Gianaroli L, Magli MC, Venturini PL, et al. Sperm aneuploidy and recurrent pregnancy loss. Reprod Biomed Online. 2004;9:312-20.
10. Molina J, Castilla JA, Castano JL, Fontes J, Mendoza N, Martínez L. Chromatin status in human ejaculated spermatozoa from infertile patients and relationship to seminal parameters. Hum Reprod. 2001;16:534-9.
11. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod. 1999;14:2801-7.
12. Gil-Villa AM, Cardona-Maya W, Agarwal A, Sharma R, Cadavid A. Role of male factor in early recurrent embryo loss: Do antioxidants have any effect? Fertil Steril. 2009;92:565-71.
13. Gil-Villa AM, Cardona-Maya WD, Agarwal A, Sharma R, Cadavid AP. Assesment of sperm factors possibly involved in early recurrent pregnancy loss. Fertil Steril. 2010;94:1465-72.
14. Gil-Villa A, Cardona-Maya W, Cadavid A. Muerte embrionaria temprana: ¿tiene influencia el factor masculino? Arch Esp Urol. 2007;60:1057-68.
15. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge, U.K.: Cambridge University Press; 1999.
16. Kruger TF, Menkeveld R, Stander FS, Lombard CJ, van Der Merwe JP, van Zyl JA, et al. Sperm morphologic features as a prognostic factor in vitro fertilization. Fertil Steril. 1986;46:1118-23.
17. Departamento de Estadística. Universidad Carlos III de Madrid. Análisis Discriminante. Última Actualización Junio 2009. Fecha de consulta: junio de 2009. Disponible en: http://halweb.uc3m.es/esp/Personal/personas/jmmarin/esp/AMult/tema6am.pdf.
18. Agarwal A, Prabakaran SA. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Indian J Exp Biol. 2005;43:963-74.
19. Chi HJ, Kim JH, Ryu CS, Lee JY, Park JS, Chung DY, et al. Protective effect of antioxidant supplementation in sperm-preparation medium against oxidative stress in human spermatozoa. Hum Reprod. 2008;23:1023-8.
20. Saleh RA, Agarwal A. Oxidative stress and male infertility: From research bench to clinical practice. J Androl. 2002;23:737-52.
21. Lopes S, Jurisicova A, Sun Jg, Casper RF. reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum Reprod. 1998;13:896-900.
22. Potts RJ, Notarianni LJ, Jefferies TM. Seminal plasma reduces exogenous oxidative damage to human sperm, determined by the measurement of DNA strand breaks and lipid peroxidation. Mutat Res. 2000;447:249-56.
23. Agarwal A, Said TM. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update. 2003;9:331-45.
24. Shamsi MB, Kumar R, Dada R. Evaluation of nuclear DNA damage in human spermatozoa in men opting for assisted reproduction. Indian J Med Res. 2008;127:115-23.
25. Carrell DT, Liu L, Peterson CM, Jones KP, Hatasaka HH, Erickson L, et al. Sperm DNA fargmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl. 2003;49:49-55.
26. Khosrowbeygi A, Zarghami N. Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters. BMC Clin Pathol. 2007;7:6.
27. Twigg J, Fulton, N, Gómez E, Irvine DS, Aitken RJ. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: Lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Hum Reprod. 1998;13:1429-36.
28. Keskes-Ammar L, Feki-Chakroun N, Rebai T, Sahnoun Z, Ghozzi H, Hammami S, et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl. 2003;49:83-94.
How to Cite
1.
Rodríguez E, Gil-Villa AM, Aguirre-Acevedo DC, Cardona-Maya W, Cadavid Ángela P. Evaluation of atypical semen parameters in individuals whose couples had a history of early recurrent embryo death: in search for a reference value. biomedica [Internet]. 2011 Apr. 16 [cited 2024 May 15];31(1):100-7. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/340
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