Brain abscess caused by Cladophialophora bantiana after renal allograft loss: A case report

John Fredy Nieto-Ríos, Douglas Ramón Villafañe-Bermúdez, Gustavo Adolfo Guerrero-Tinoco, Isabel Cristina Ramírez-Sánchez, Lina María Serna-Higuita, Arbey Aristizábal-Alzate, Catalina Ocampo-Kohn, Gabriel Varela, Gustavo Zuluaga-Valencia, .

Keywords: Phaeohyphomycosis, fungi, immunosuppression, kidney transplantation, brain abscess

Abstract

Cerebral feohifomycosis are severe infections caused by dematiaceous fungi. Cladophialophora bantiana is one of the most commonly isolated species; it has central nervous system tropism and it often manifests as a brain abscess in immunocompetent patients. In immunocompromised patients, it can lead to brain abscesses and disseminated infections.
Despite the availability of broad-spectrum antifungal drugs, it is a must to perform surgical management, in addition to drug therapy. However, mortality is high. The diagnostic approach must be invasive to establish a timely diagnosis and direct treatment based on culture and susceptibility tests.
We report a case of brain abscess caused by C. bantiana in an immunosuppressed patient who was treated with surgical resection and voriconazole with an adequate response to therapy and without neurological sequels.

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  • John Fredy Nieto-Ríos Departamento de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín, Colombia; Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia
  • Douglas Ramón Villafañe-Bermúdez Departamento de Nefrología Pediátrica, Universidad de Antioquia, Medellín, Colombia
  • Gustavo Adolfo Guerrero-Tinoco Departamento de Nefrología Pediátrica, Universidad de Antioquia, Medellín, Colombia
  • Isabel Cristina Ramírez-Sánchez Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia; Departamento de Infectología, Hospital Pablo Tobón Uribe, Medellín, Colombia
  • Lina María Serna-Higuita Institute for Clinical Epidemiology and Applied Biometrics, Eberhard Karls University, Tübingen,
  • Arbey Aristizábal-Alzate Departamento de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín, Colombia
  • Catalina Ocampo-Kohn Departamento de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín, Colombia; Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia
  • Gabriel Varela Departamento de Patología, Hospital Pablo Tobón Uribe, Medellín, Colombia
  • Gustavo Zuluaga-Valencia Departamento de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín, Colombia

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How to Cite
1.
Nieto-Ríos JF, Villafañe-Bermúdez DR, Guerrero-Tinoco GA, Ramírez-Sánchez IC, Serna-Higuita LM, Aristizábal-Alzate A, et al. Brain abscess caused by Cladophialophora bantiana after renal allograft loss: A case report. biomedica [Internet]. 2019 Aug. 1 [cited 2024 May 17];39(Supl. 2):20-5. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/4471

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Published
2019-08-01

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