Brain abscess caused by Cladophialophora bantiana after renal allograft loss: A case report
Abstract
Cerebral feohifomycosis are severe infections caused by dematiaceous fungi. Cladophialophora bantiana is one of the most commonly isolated species; it has central nervous system tropism and it often manifests as a brain abscess in immunocompetent patients. In immunocompromised patients, it can lead to brain abscesses and disseminated infections.
Despite the availability of broad-spectrum antifungal drugs, it is a must to perform surgical management, in addition to drug therapy. However, mortality is high. The diagnostic approach must be invasive to establish a timely diagnosis and direct treatment based on culture and susceptibility tests.
We report a case of brain abscess caused by C. bantiana in an immunosuppressed patient who was treated with surgical resection and voriconazole with an adequate response to therapy and without neurological sequels.
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References
Li DM, de Hoog GS. Cerebral phaeohyphomycosis--a cure at what lengths? Lancet Infect Dis. 2009;9:376-83. https://doi.org/10.1016/S1473-3099(09)70131-8
de Hoog G, Guarro J, Gene J, Figueras M. Atlas of clinical fungi. Second edition. Utrecht: Centraalbureau voor Schimmelcultures; 2001. p. 51-2.
Kantarcioglu AS, de Hoog GS. Infections of the central nervous system by melanized fungi: A review of cases presented between 1999 and 2004. Mycoses. 2004;47:4-13. https://doi.org/10.1046/j.1439-0507.2003.00956.x
Revankar SG, Sutton DA, Rinaldi MG. Primary central nervous system phaeohyphomycosis: A review of 101 cases. Clin Infect Dis. 2004;38:206-16. https://doi.org/10.1086/380635
Nieto-Ríos JF, Zuluaga M, Higuita LM, Flórez A, Bello-Márquez DC, Aristizábal A, et al. Primary hiperoxaluria diagnosed after kidney transplantation: Report of 2 cases and literature review. J Bras Nefrol. 2017;39:462-6. https://doi.org/10.5935/0101-2800.20170081
Hospenthal DR. Uncommon fungi and related species. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett´s Principles and Practice of Infectious Disease. Eight edition. Philadelphia, PA: Saunders; 2015. p. 3003-15. https://doi.org/10.1016/C2012-1-00075-6
Chakrabarti A, Kaur H, Rudramurthy SM, Appannanavar SB, Patel A, Mukherjee KK, et al. Brain abscess due to Cladophialophora bantiana: A review of 124 cases. Med Mycol. 2016;54:111-9. https://doi.org/10.1093/mmy/myv091
Huang WM, Fan YM, Li W, Yang WW. Brain abscess caused by Cladophialophora bantiana in China. J Med Microbiol. 2011;60:1872-4. https://doi.org/10.1099/jmm.0.032532-0
Nampoory MR, Khan ZU, Johny KV, Constandi JN, Gupta RK, Al-Muzairi I, et al. Invasive fungal infections in renal transplant recipients. J Infect. 1996;33:95-101. https://doi.org/10.1016/S0163-4453(96)92986-2
Shoham S. Emerging fungal infections in solid organ transplant recipients. Infect Dis Clin North Am. 2013;27:305-16. https://doi.org/10.1016/j.idc.2013.02.004
Centers for Disease Control and Prevention. Exophiala infection from contaminated injectable steroids prepared by a compounding pharmacy--United States, July-November 2002. MMWR Morb Mortal Wkly Rep. 2002;51:1109-12.
McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP, Walsh TJ. Mold infections of the central nervous system. N Engl J Med. 2014;371:150-60. https://doi.org/10.1056/NEJMra1216008
Queiroz-Telles F, Esterre P, Pérez-Blanco M, Vitale RG, Salgado CG, Bonifaz A. Chromoblastomycosis: An overview of clinical manifestations, diagnosis and treatment. Med Mycol. 2009;47:3-15. https://doi.org/10.1080/13693780802538001
Schoeffler A, Redon E, Contet-Audonneau N, Cuny JF, Lo-Jeanpierre B, Beurey P, et al. Cutaneous phaeohyphomycosis due to Cladophialophora bantiana. Ann Dermatol Venereol. 2011;138:504-7. https://doi.org/10.1016/j.annder.2011.01.044
Silveira ER, Resende MA, Mariano VS, Coura WA, Alkmim LD, Vianna LB, et al. Brain abscess caused by Cladophialophora (Xylohypha) bantiana in a renal transplant patient. Transpl Infect Dis. 2003;5:104-7. https://doi.org/10.1034/j.1399-3062.2003.00020.x
Silveira F, Nucci M. Emergence of black moulds in fungal disease: Epidemiology and therapy. Curr Opin Infect Dis. 2001;14:679-84.
Harrison DK, Moser S, Palmer CA. Central nervous system infections in transplant recipients by Cladophialophora bantiana. South Med J. 2008;101:292-6. https://doi.org/10.1097/SMJ.0b013e318164e289
Ben-Ami R, Lewis RE, Raad, II, Kontoyiannis DP. Phaeohyphomycosis in a tertiary care cancer center. Clin Infect Dis. 2009;48:1033-41. https://doi.org/10.1086/597400
Jacobs CS, Etherton MR, Lyons JL. Fungal infections of the central nervous system. Curr Infect Dis Rep. 2014;16:449. https://doi.org/10.1007/s11908-014-0449-2
Roche M, Redmond RM, O’Neill S, Smyth E. A case of multiple cerebral abscesses due to infection with Cladophialophora bantiana. J Infect. 2005;51:e285-8. https://doi.org/10.1016/j.jinf.2005.02.029
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