Serum platelet-activating factor acetylhydrolase activity in dengue patients of African or mestizo descendency
Keywords:
1-alkyl-2-acetylglycerophosphocholine esterase, dengue, ethnic groups, Colombia
Abstract
Introduction: Severe dengue infection is characterized by enhanced vascular permeability produced by cytokines and biochemical mediators. One of these mediators is the platelet-activating factor.Degradation of platelet-activating factor is accomplished by its specific acetylhydrolase. Down or up regulation of this enzyme has been linked to several diseases. However, the role of this enzyme in dengue infection is unknown, a well as whether differential activity occurs by ethnic group.
Objective: The activity of the platelet-activating factor-acetylhydrolase was compared in patients infected with dengue virus in two ethnic groups.
Material and methods: A descriptive, prospective and longitudinal study was made in two states of Colombia (Antioquia and Chocó). Serum samples were taken from 43 mestizo patients and 33 patients of African descent, each taken during five consecutive days of the acute dengue phase. A second serum sample was taken during the convalescent phase.
Results: The mestizo patients showed higher frequency of dengue hemorrhagic fever than the patients of African descent (23.3% vs. 12.1%, p=0.25). The serum activity of the platelet-activating factor acetylhydrolase was higher in African descendents than in mestizos (0.89, CI: 0.72-1.10 vs. 0.76 CI: 0-1.03, p<0.001). This relationship is maintained for occurence of dengue fever (0.89, CI: 0.73-1.10 vs. 0.73, CI: 0-1.05, p<0.001), but not significant for dengue hemorrhagic fever (0.88, CI: 0.69-1.12 vs. 0.83, CI: 0.71-1.08, p=0.89).
Conclusion. An increased production of platelet-activating factor-acetylhydrolase occurs in the serum of dengue-infected African descendants. However, a study of the frequencies of polymorphisms for this enzyme will permit more conclusive support for these observations.Introduction. Severe dengue infection is characterized for enhanced permeability vascular, produced for cytokines and chemical mediators. One of these is the platelet-activating factor. Platelet-activating factor-acetylhydrolase is the enzyme responsible of its degradation. Down or up regulation of this enzyme has been linked to several diseases. However the role of this enzyme in dengue infection is still unknown, nor is known whether there is differential activity according to ethnic group.
Objective. To compare the activity in serum of the platelet-activating factor-acetylhydrolase in patients infected with dengue virus in two ethnic groups.
Material and methods. A Descriptive, prospective and longitudinal study was made in two states of Colombia. To 43 mestizo patients and to 33 afro-descendent patients with dengue infection was taken a serum sample during five consecutive days in acute phase and other serum sample was taken in convalescent phase.
Results. The mestizo patients showed higher frequency of cases of dengue hemorrhagic fever that the afro-descendant patients (23.3% vs. 12.1%, p=0.248).
The activity in serum of the platelet-activating factor acetylhydrolase (median (25 percentile and 75 percentile) was higher in afro-descendents than in mestizos (0.89 (0.72-1.10) vs. 0.76 (0-1.03), p=0.000). These behaviors are preserved for dengue fever (0.89 (0.73-1.10) vs. 0.73 (0- 1.05), p=0.000) and dengue hemorrhagic fever 0.88 (0.69-1.12) vs. 0.83 (0.71-1.08), p=0.893).
Conclusion. These findings show increased production of platelet-activating factor-acetylhydrolase in the afro-descendants. However, it is necessary development studies of polymorphisms of this enzyme which would give conclusive results.
Downloads
Download data is not yet available.
References
1. Programa Especial para Investigación y Capacitación en Enfermedades Tropicales (TDR), Organización Mundial de la Salud. Dengue. Guías para el diagnóstico, tratamiento, prevención y control; 2009. p. 3. Fecha de consulta: 24 de enero de 2010. Disponible en: http://whqlibdoc.who.int/publications/2009/9789995479213_spa.pdf.
2. Instituto Nacional de Salud. Estadística en Salud Pública. Vigilancia rutinaria. Fecha de consulta: 6 de abril 2011. Disponible en: http://www.ins.gov.co/?idcategoria=85465#.
3. Instituto Nacional de Salud. Boletín No. 29. Vigilancia epidemia por dengue en Colombia. Fecha de consulta: 23 de agosto 2010. Disponible en: http://new.paho.org/col/index.php?option=com_content&task=view&id=810&Itemid=468.
4. Kurane I. Dengue hemorrhagic fever with special emphasis on immunopathogenesis. Comp Immunol Microbiol Infect Dis. 2007;30:329-40.
5. Cardier JE, Mariño E, Romano E, Taylor P, Liprandi F, Bosch N, et al. Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: Possible roll of TNF-α in endothelial cell damage in dengue. Cytokine. 2005;30:359-65.
6. Rosen L. The Emperor's new clothes revisited or reflections on the pathogenesis of dengue hemorrhagic fever. Am J Trop Med Hyg. 1997;26:337-43.
7. Ricco-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, et al. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997;230:244-51.
8. Balmaseda A, Hammond SN, Pérez L, Tellez Y, Saborío SI, Mercado JC, et al. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg. 2006;74:449-56.
9. Kumaria R. Correlation of disease spectrum among four dengue serotypes: A five years hospital based study from India. Braz J Infect Dis. 2010;14:141-6.
10. Murgue B, Roche C, Chungue E, Deparis X. Prospective study of the duration and magnitude of viraemia in children hospitalized during the 1996-1997 dengue-2 outbreak in French Polynesia. J Med Virol. 2000;60:432-8.
11. Guzmán MG, Kouri G, Valdés L, Bravo J, Álvarez M, Vásquez S, et al. Epidemiological studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol. 2000;152:793-9.
12. Halstead SB. Pathogenesis of dengue. Challenges to molecular biology. Science. 1988;238:476-81.
13. Rothman AL. Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis. Curr Top Microbiol Immunol. 2010;338:83-98.
14. Chaturvedi UC, Elbishbishi EA, Agarwal R, Raghupathy R, Nagar R, Tandon R, et al. Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol. 1999;59:335-40.
15. Juffrie M, Meer GM, Hack CE, Haasnoot K, Sutaryo, Veerman AJ. Inflammatory mediators in dengue virus infection in children interleukin-6 and its relation to C-reactive protein and secret phospholipase A2. Am J Trop Med Hyg. 2001;65:70-5.
16. Pinto LM, Oliveira SO, Braga EL, Nogueira RM, Kubelka CF. Increased pro-inflamatory cytokines (TNF-alpha and IL-6) and anti-inflamatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Mem Inst Oswaldo Cruz. 1999;94:387-94.
17. Hober D, Poli L, Roblin B, Gestas P, Chunge E, Granic G, et al. Serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in dengue-infected patients. Am J Trop Med Hyg. 1993;48:324-31.
18. Restrepo BN, Isaza DM, Salazar CL, Ramírez R, Ospina M, Álvarez LG. Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gamma in infants with and without dengue. Rev Soc Bras Med Trop. 2008;41:6-10.
19. Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, et al. Haiti: Absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg. 2001;65:180-3.
20. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11:480-96.
21. Rioth M, Beauharnais CA, Noel F, Ikizler MR, Mehta S, Zhu Y, et al. Serologic imprint of dengue virus in urban Haiti: Characterization of humoral immunity to dengue in infants and young children. Am J Trop Med Hyg. 2011;84:630-6.
22. Bravo J, Guzmán MG, Kouri G. Why dengue hemorrhagic in Cuba? 1. Individual risk factors for dengue hemorrhagic fever/dengue shock syndrome. Trans R Soc Trop Med Hyg. 1987;8:816-20.
23. Guzmán MG, Kouri GP, Vásquez S, Rosario D, Bravo JR, Valdés L. DHF epidemics in Cuba, 1981 and 1987: Some interesting observations. Dengue Bull WHO. 1999;23:39-43.
24. Sierra B, Kourí G, Guzmán MG. Race: A risk factor for dengue hemorrhagic fever. Arch Virol. 2007;152:533-42.
25. Shekhar KC, Huat OL. Epidemiology of dengue/dengue hemorrhagic fever in Malaysia: A retrospective epidemiological study 1973-1987. Part I: dengue hemorrhagic fever (DHF). Asia Pac J Public Health. 1992;6:15-25.
26. Kosaka T, Yamaguchi M, Soda Y, Kishimoto T, Tago A, Toyosato M, et al. Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. Clin Chim Acta. 2000;296:151-61.
27. Karasawa K, Harada A, Satoh N, Inoue K, Setaka M. Plasma platelet activating factor-acetylhydrolase (PAF-AH). Prog Lipid Res. 2003;42:93-114.
28. Oshimoto H, Okamura S, Iida T, Ishikawa T, Hosaka K, Mori M. Diagnostic value of the serum platelet-activating factor acetylhydrolase activity in inflammatory bowel disease. Tohoku J Exp Med. 2005;207:65-71.
29. Kosaka T, Yamaguchi M, Miyanaga K, Mizuno K. Serum platelet-activating factor acetyhydrolasa (PAF-AH) activity in more than 3000 healthy Japanese. Clin Chim Acta. 2001;312:179-83.
30. Karabina SA, Ninio E. Plasma PAF-acetylhydrolase: an unfulfilled promise? Biochim Biophys Acta. 2006;1761:1351-8.
31. Arai H, Koizumi H, Aoki J, Inoue K. Platelet-activating factor acetylhydrolase (PAF-AH). J Biochem. 2002;131:635-40.
32. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010;68:225-30.
33. Graham RM, Stephens CJ, Silvester W, Leong LL, Sturm MJ, Taylor RR. Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. Crit Care Med. 1994;22:204-12.
34. Gomes RN, Bozza FA, Amâncio RT, Japiassú AM, Vianna RC, Larangeira AP, et al. Exogenous plateletactivating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock. 2006;26:41-9.
35. Miwa M, Miyake T, Yamanaka T, Sugatani J, Suzuki Y, Sakata S, et al. Characterization of serum platelet-activating factor (PAF) acetylhydrolase: Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J Clin Invest. 1988;82:1983-91.
36. Caini P, Guerra CT, Giannini C, Giannelli F, Gragnani L, Petrarca A, et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. J Viral Hepat. 2007;14:22-8.
37. Guerra CT, Caini P, Giannini C, Giannelli F, Gragnani L, Petrarca A, et al. Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. Dig Liver Dis. 2007;39 (Suppl.1):S76-82.
38. Satoh K, Imaizumi T, Kawamura Y, Yoshida H, Takamatsu S, Takamatsu M. Increased activity of platelet activating factor acetylhydrolase in plasma low density lipoprotein from patients with essential hypertension. Prostaglandins. 1989;37:673-82.
39. Satoh K, Yoshida H, Imaizumi T, Takamatsu S, Mizuno S. Platelet-activating factor acetylhydrolase in plasma lipoproteins from patients with ischemic stroke. Stroke. 1992;23:1091-2.
40. Hofmann B, Ruhling K, Spangenberg P, Ostermann G. Enhanced degradation of platelet-activating factor in serum from diabetic patients. Haemostasis. 1989;19:180-4.
41. Yang KD, Lee CS, Shaio MF. A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. Acta Microbiol Immunol Hung. 1995;42:403-7.
42. Souza DG, Fagundes CT, Sousa LP, Amaral FA, Souza RS, Souza AL, et al. Essential role of platelet-activating factor receptor in the pathogenesis of dengue virus infection. Proc Natl Acad Sci USA. 2009;106:14138-43.
43. Seet RC, Lee CY, Lim EC, Quek AM, Yeo LL, Huang SH, et al. Oxidative damage in dengue fever. Free Radic Biol Med. 2009;47:375-80.
44. PAHO. Dengue hemorrhagic fever in the Americas: Guidelines for prevention and control. Scientific publication no. 548. Washington, D.C.: Panamerican Health Organization; 1995.
45. Serebruany VL, Gurbel PA, Murugesan SR, Lowry DR, Sturm E, Svetlov SI. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. Cardiology.1998;90:127-30.
46. Tuttolomondo A, Di Raimondo D, Di Sciacca R, Pinto A, Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14:3574-89.
47. Sonnerborg A, Ayehunie S, Julander I. Elevated levels of circulating tumor necrosis alpha in human immunodeficiency virus type 1-infected Africans living in Sweden. Clin Diagn Lab Immunol. 1995;2:118-9.
48. Kimball T, Eslwick RK, Shiffman M. Ethnicity and cytokine production gauge responses of patients with hepatitis C to interferon-alpha therapy. J Med Virol. 2001;65: 510-6.
49. Thio CL, Thomas DL, Goedert JJ, Vlahov D, Nelson KE, Hilgartner MW, et al. Racial differences in HLA class II associations with hepatitis C virus outcomes. J Infect Dis. 2001;184:16-21.
50. Jeffers LJ. Treating hepatitis C in African Americans. Liver Int. 2007;27:313-22.
51. Restrepo BN, Ramírez RE, Arboleda M, Álvarez G, Ospina M, Díaz FJ. Serum levels of cytokines in two ethnic groups with dengue virus infection. Am J Trop Med Hyg. 2008;79:673-7.
52. Blanton RE, Silva LK, Morato VG, Parrado AR, Dias JP, Melo PR, et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Eur J Hum Genet. 2008;16:762-65.
53. Tjoelker LW, Stafforini DM. Platelet-activating factor acetylhydrolases in health and disease. Biochim Biophys Acta. 2000;1488:102-23.
54. Fan P, Liu HW, Wang XS, Zhang F, Song Q, Li Q, et al. Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. Hum Reprod. 2010;25:1288-94.
55. Ambrosio G, Oriente A, Napoli C, Palumbo G, Chiariello P, Marone G, et al. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes plateletactivating factor. J Clin Invest. 1994;93:2408-16.
2. Instituto Nacional de Salud. Estadística en Salud Pública. Vigilancia rutinaria. Fecha de consulta: 6 de abril 2011. Disponible en: http://www.ins.gov.co/?idcategoria=85465#.
3. Instituto Nacional de Salud. Boletín No. 29. Vigilancia epidemia por dengue en Colombia. Fecha de consulta: 23 de agosto 2010. Disponible en: http://new.paho.org/col/index.php?option=com_content&task=view&id=810&Itemid=468.
4. Kurane I. Dengue hemorrhagic fever with special emphasis on immunopathogenesis. Comp Immunol Microbiol Infect Dis. 2007;30:329-40.
5. Cardier JE, Mariño E, Romano E, Taylor P, Liprandi F, Bosch N, et al. Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: Possible roll of TNF-α in endothelial cell damage in dengue. Cytokine. 2005;30:359-65.
6. Rosen L. The Emperor's new clothes revisited or reflections on the pathogenesis of dengue hemorrhagic fever. Am J Trop Med Hyg. 1997;26:337-43.
7. Ricco-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, et al. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997;230:244-51.
8. Balmaseda A, Hammond SN, Pérez L, Tellez Y, Saborío SI, Mercado JC, et al. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg. 2006;74:449-56.
9. Kumaria R. Correlation of disease spectrum among four dengue serotypes: A five years hospital based study from India. Braz J Infect Dis. 2010;14:141-6.
10. Murgue B, Roche C, Chungue E, Deparis X. Prospective study of the duration and magnitude of viraemia in children hospitalized during the 1996-1997 dengue-2 outbreak in French Polynesia. J Med Virol. 2000;60:432-8.
11. Guzmán MG, Kouri G, Valdés L, Bravo J, Álvarez M, Vásquez S, et al. Epidemiological studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol. 2000;152:793-9.
12. Halstead SB. Pathogenesis of dengue. Challenges to molecular biology. Science. 1988;238:476-81.
13. Rothman AL. Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis. Curr Top Microbiol Immunol. 2010;338:83-98.
14. Chaturvedi UC, Elbishbishi EA, Agarwal R, Raghupathy R, Nagar R, Tandon R, et al. Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol. 1999;59:335-40.
15. Juffrie M, Meer GM, Hack CE, Haasnoot K, Sutaryo, Veerman AJ. Inflammatory mediators in dengue virus infection in children interleukin-6 and its relation to C-reactive protein and secret phospholipase A2. Am J Trop Med Hyg. 2001;65:70-5.
16. Pinto LM, Oliveira SO, Braga EL, Nogueira RM, Kubelka CF. Increased pro-inflamatory cytokines (TNF-alpha and IL-6) and anti-inflamatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Mem Inst Oswaldo Cruz. 1999;94:387-94.
17. Hober D, Poli L, Roblin B, Gestas P, Chunge E, Granic G, et al. Serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in dengue-infected patients. Am J Trop Med Hyg. 1993;48:324-31.
18. Restrepo BN, Isaza DM, Salazar CL, Ramírez R, Ospina M, Álvarez LG. Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gamma in infants with and without dengue. Rev Soc Bras Med Trop. 2008;41:6-10.
19. Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, et al. Haiti: Absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg. 2001;65:180-3.
20. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11:480-96.
21. Rioth M, Beauharnais CA, Noel F, Ikizler MR, Mehta S, Zhu Y, et al. Serologic imprint of dengue virus in urban Haiti: Characterization of humoral immunity to dengue in infants and young children. Am J Trop Med Hyg. 2011;84:630-6.
22. Bravo J, Guzmán MG, Kouri G. Why dengue hemorrhagic in Cuba? 1. Individual risk factors for dengue hemorrhagic fever/dengue shock syndrome. Trans R Soc Trop Med Hyg. 1987;8:816-20.
23. Guzmán MG, Kouri GP, Vásquez S, Rosario D, Bravo JR, Valdés L. DHF epidemics in Cuba, 1981 and 1987: Some interesting observations. Dengue Bull WHO. 1999;23:39-43.
24. Sierra B, Kourí G, Guzmán MG. Race: A risk factor for dengue hemorrhagic fever. Arch Virol. 2007;152:533-42.
25. Shekhar KC, Huat OL. Epidemiology of dengue/dengue hemorrhagic fever in Malaysia: A retrospective epidemiological study 1973-1987. Part I: dengue hemorrhagic fever (DHF). Asia Pac J Public Health. 1992;6:15-25.
26. Kosaka T, Yamaguchi M, Soda Y, Kishimoto T, Tago A, Toyosato M, et al. Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. Clin Chim Acta. 2000;296:151-61.
27. Karasawa K, Harada A, Satoh N, Inoue K, Setaka M. Plasma platelet activating factor-acetylhydrolase (PAF-AH). Prog Lipid Res. 2003;42:93-114.
28. Oshimoto H, Okamura S, Iida T, Ishikawa T, Hosaka K, Mori M. Diagnostic value of the serum platelet-activating factor acetylhydrolase activity in inflammatory bowel disease. Tohoku J Exp Med. 2005;207:65-71.
29. Kosaka T, Yamaguchi M, Miyanaga K, Mizuno K. Serum platelet-activating factor acetyhydrolasa (PAF-AH) activity in more than 3000 healthy Japanese. Clin Chim Acta. 2001;312:179-83.
30. Karabina SA, Ninio E. Plasma PAF-acetylhydrolase: an unfulfilled promise? Biochim Biophys Acta. 2006;1761:1351-8.
31. Arai H, Koizumi H, Aoki J, Inoue K. Platelet-activating factor acetylhydrolase (PAF-AH). J Biochem. 2002;131:635-40.
32. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010;68:225-30.
33. Graham RM, Stephens CJ, Silvester W, Leong LL, Sturm MJ, Taylor RR. Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. Crit Care Med. 1994;22:204-12.
34. Gomes RN, Bozza FA, Amâncio RT, Japiassú AM, Vianna RC, Larangeira AP, et al. Exogenous plateletactivating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock. 2006;26:41-9.
35. Miwa M, Miyake T, Yamanaka T, Sugatani J, Suzuki Y, Sakata S, et al. Characterization of serum platelet-activating factor (PAF) acetylhydrolase: Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J Clin Invest. 1988;82:1983-91.
36. Caini P, Guerra CT, Giannini C, Giannelli F, Gragnani L, Petrarca A, et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. J Viral Hepat. 2007;14:22-8.
37. Guerra CT, Caini P, Giannini C, Giannelli F, Gragnani L, Petrarca A, et al. Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. Dig Liver Dis. 2007;39 (Suppl.1):S76-82.
38. Satoh K, Imaizumi T, Kawamura Y, Yoshida H, Takamatsu S, Takamatsu M. Increased activity of platelet activating factor acetylhydrolase in plasma low density lipoprotein from patients with essential hypertension. Prostaglandins. 1989;37:673-82.
39. Satoh K, Yoshida H, Imaizumi T, Takamatsu S, Mizuno S. Platelet-activating factor acetylhydrolase in plasma lipoproteins from patients with ischemic stroke. Stroke. 1992;23:1091-2.
40. Hofmann B, Ruhling K, Spangenberg P, Ostermann G. Enhanced degradation of platelet-activating factor in serum from diabetic patients. Haemostasis. 1989;19:180-4.
41. Yang KD, Lee CS, Shaio MF. A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. Acta Microbiol Immunol Hung. 1995;42:403-7.
42. Souza DG, Fagundes CT, Sousa LP, Amaral FA, Souza RS, Souza AL, et al. Essential role of platelet-activating factor receptor in the pathogenesis of dengue virus infection. Proc Natl Acad Sci USA. 2009;106:14138-43.
43. Seet RC, Lee CY, Lim EC, Quek AM, Yeo LL, Huang SH, et al. Oxidative damage in dengue fever. Free Radic Biol Med. 2009;47:375-80.
44. PAHO. Dengue hemorrhagic fever in the Americas: Guidelines for prevention and control. Scientific publication no. 548. Washington, D.C.: Panamerican Health Organization; 1995.
45. Serebruany VL, Gurbel PA, Murugesan SR, Lowry DR, Sturm E, Svetlov SI. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. Cardiology.1998;90:127-30.
46. Tuttolomondo A, Di Raimondo D, Di Sciacca R, Pinto A, Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14:3574-89.
47. Sonnerborg A, Ayehunie S, Julander I. Elevated levels of circulating tumor necrosis alpha in human immunodeficiency virus type 1-infected Africans living in Sweden. Clin Diagn Lab Immunol. 1995;2:118-9.
48. Kimball T, Eslwick RK, Shiffman M. Ethnicity and cytokine production gauge responses of patients with hepatitis C to interferon-alpha therapy. J Med Virol. 2001;65: 510-6.
49. Thio CL, Thomas DL, Goedert JJ, Vlahov D, Nelson KE, Hilgartner MW, et al. Racial differences in HLA class II associations with hepatitis C virus outcomes. J Infect Dis. 2001;184:16-21.
50. Jeffers LJ. Treating hepatitis C in African Americans. Liver Int. 2007;27:313-22.
51. Restrepo BN, Ramírez RE, Arboleda M, Álvarez G, Ospina M, Díaz FJ. Serum levels of cytokines in two ethnic groups with dengue virus infection. Am J Trop Med Hyg. 2008;79:673-7.
52. Blanton RE, Silva LK, Morato VG, Parrado AR, Dias JP, Melo PR, et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Eur J Hum Genet. 2008;16:762-65.
53. Tjoelker LW, Stafforini DM. Platelet-activating factor acetylhydrolases in health and disease. Biochim Biophys Acta. 2000;1488:102-23.
54. Fan P, Liu HW, Wang XS, Zhang F, Song Q, Li Q, et al. Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. Hum Reprod. 2010;25:1288-94.
55. Ambrosio G, Oriente A, Napoli C, Palumbo G, Chiariello P, Marone G, et al. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes plateletactivating factor. J Clin Invest. 1994;93:2408-16.
How to Cite
1.
Restrepo BN, Arboleda M, Ramírez R, Álvarez G. Serum platelet-activating factor acetylhydrolase activity in dengue patients of African or mestizo descendency. biomedica [Internet]. 2011 Jun. 30 [cited 2024 May 12];31(4):599-607. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/451
Some similar items:
- Lucas Alcalá, Juliana Quintero, Catalina González-Uribe, Helena Brochero, Estimation of Aedes aegypti (L.) (Diptera: Culicidae) productivity in households and public spaces in a dengue endemic city in Colombia , Biomedica: Vol. 35 No. 2 (2015)
- Mabel Carabalí, Clara Beatriz Ocampo, María Eugenia Toledo, Lyda Osorio, Mass communication of dengue surveillance data: effect of an intervention in Guadalajara de Buga, Colombia , Biomedica: Vol. 33 (2013): Suplemento 1, Fiebres hemorrágicas
- Clara Beatriz Ocampo, Camila González, Carlos A. Morales, Mauricio Pérez, Dawn Wesson, Charles S. Apperson, Evaluation of community-based strategies for Aedes aegypti control inside houses , Biomedica: Vol. 29 No. 2 (2009)
- Ana María Perilla, Camilo González, Sandra Liliana Valderrama, Natasha Vanegas, Bibiana Chavarro, Luis Carlos Triana, José Roberto Támara, Carlos Arturo Álvarez, Necrotizing pneumonia by community-acquired, methicillin-resistant Staphylococcus aureus in Colombia , Biomedica: Vol. 29 No. 4 (2009)
- Yolanda Lucía López, Claudia González, Berta Natalia Gallego, Ana Lida Moreno, Stewardship of public health surveillance in the health system in Colombia: a cases study , Biomedica: Vol. 29 No. 4 (2009)
- Oscar Fernando Herrán, María F. Ardila, Categories of alcohol consumers and the criteria for classification , Biomedica: Vol. 29 No. 4 (2009)
- María Elena Cuéllar-Jiménez, Olga Lucía Velásquez-Escobar, Ranulfo González-Obando, Carlos Andrés Morales-Reichmann, Detection of Aedes albopictus (Skuse) (Diptera: Culicidae) in the city of Cali, Valle del Cauca, Colombia , Biomedica: Vol. 27 No. 2 (2007)
- Natalia Houghton-Triviño, Katherine Martín, Kris Giaya, Jairo A. Rodríguez, Irene Bosch, Jaime E. Castellanos, Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis , Biomedica: Vol. 30 No. 4 (2010)
- Lorenzo Cáceres , Cipriano Ayarza, Damaris Bernal, Evaluation of the biological efficacy and susceptibility in Aedes aegypti to the pyrethroid insecticides deltamethrin and cyfluthrin during the Zika virus outbreak in Kuna Yala, Panama , Biomedica: Vol. 43 No. 2 (2023)
- Greizy López, Nancy Yaneth Gelvez, Martalucía Tamayo, Mutational frequencies in usherin (USH2A gene) in 26 Colombian individuals with Usher syndrome type II , Biomedica: Vol. 31 No. 1 (2011)
Issue
Section
Original articles
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
