Intestinal apicomplexan parasitoses among a hospital-based population in Honduras, 2013-2019
Abstract
Introduction: Intestinal apicomplexa protozoa are a recognized cause of gastroenteritis. They are endemic in Honduras and their epidemiology varies in different population groups.
Objective: To identify risk factors for cyclosporiasis, cryptosporidiosis, and cystoisosporiasis.
Materials and methods: We conducted a case-control study in a hospital-based population. We performed the diagnosis using the modified Ziehl-Neelsen staining technique and collected the information from laboratory records and clinical charts.
Results: Cyclosporiasis was associated with diarrhea (OR=2.28; 95%CI: 1.10-4.89), weight loss (OR=12.7; 95%CI: 2.49-122.00), watery stools (OR=2.42; 95%CI: 1.26-4.65),
and infection with another protozoan (OR=3.13; 95%CI: 1.66-5.95). Cryptosporidiosis was associated with HIV infection (OR=15.43; 95%CI: 3.34-71.22), diarrhea (OR=3.52; 95%CI: 1.40-9.40), lymphopenia (OR=6.16; 95%CI: 1.99-18.98), and green color stools (OR=3.00; 95%CI: 1.23-7.30). Cystoisosporiasis was associated with HIV infection (OR=11.20; 95%CI: 3.53-35.44), diarrhea (OR=7.30; 95%CI: 1.89-28.52), leukopenia (OR=4.28; 95%CI: 1.33-13.75), green color stools (OR=11.59; 95%CI: 1.16-558.60), and Charcot-Leyden crystals (OR=11.59; 95%CI: 1.16-558.60).
Conclusions: In this hospital-based population from Honduras, HIV infection was a risk factor for cryptosporidiosis and cystoisosporiasis, but not for cyclosporiasis.
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References
Li J, Wang R, Chen Y, Xiao L, Zhang L. Cyclospora cayetanensis infection in humans: Biological characteristics, clinical features, epidemiology, detection method and treatment. Parasitology. 2020;147:160-70. https://doi.org/10.1017/S0031182019001471
Platss-Mills J, Babji S, Bodhidatta L, Gratz J, Haque R, Havt A, et al. Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MALED). Lancet Glob Health. 2015;3:e564-75. https://doi.org/10.1016/S2214-109X(15)00151-5
Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study. Lancet. 2013;382:209-22. https://doi.org/10.1016/S0140-6736(13)60844-2
Dillingham R, Pinkerton R, Leger P, Severe P, Guerrant RL, Pape JW, et al. High early mortality in patients with chronic acquired immunodeficiency syndrome diarrhea initiating antiretroviral therapy in Haiti: A case-control study. Am J Trop Med Hyg. 2009;80:1060-4.
Bouzid M, Kintz E, Hunter PR. Risk factors for Cryptosporidium infection in low and middle income countries: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2018;12:e0006553. https://doi.org/10.1371/journal.pntd.0006553
Dubey JP, Almeria S. Cystoisospora belli infections in humans: the past 100 years. Parasitology. 2019;146:1490-527. https://doi.org/10.1017/S0031182019000957
Kaminsky R, Canales M. Criptosporidiosis en Honduras. Rev Méd Hondur. 1986;54:268-77.
Kaminsky R. Isospora belli en Honduras. Parasitologia Dia. 1990;14:73-8.
Kaminsky R. Cyclospora cayetanensis: nuevo apicomplexa intestinal, actualización y presentación de casos en el Hospital Escuela. Rev Méd Hondur. 1997;65:68-72.
Kaminsky, RG. Comparación epidemiológica de apicomplexa intestinales en el Hospital Escuela, Honduras. Rev Méd Hondur. 2002;70:164-72.
Kaminsky RG, Lagos J, Raudales-Santos G, Urrutia S. Marked seasonality of Cyclospora cayetanensis infections: Ten-year observation of hospital cases, Honduras. BMC Infectious Diseases. 2016;16:66. https://doi.org/10.1186/s12879-016-1393-6
World Health Organization. Bench Aids for the diagnosis of intestinal parasites. Second edition. Access: July 10, 2021. Available from: https://www.who.int/intestinal_worms/resources/9789241515344/en/
Osman M, El Safadi D, Cian A, Benamrouz S, Nourrisson C, Poirier P, et al. Prevalence and risk factors for intestinal protozoan infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among schoolchildren in Tripoli, Lebanon. PLoS Negl Trop Dis. 2016;10:e0004496. https://doi.org/10.1371/journal.pntd.0004496
Almeria S, Cinar HN, Dubey JP. Cyclospora cayetanensis and Cyclosporiasis: An update. Microorganisms. 2019;7:317. https://doi.org/10.3390/microorganisms7090317
Gibney KB, O’Toole J, Sinclair M, Leder K. Burden of disease attributed to waterborne transmission of selected enteric pathogens, Australia, 2010. Am J Trop Med Hyg. 2017;96:1400-3. https://doi.org/10.4269/ajtmh.16-0907
Orozco-Mosqueda GE, Martínez-Loya O, Ortega Y. Cyclospora cayetanensis in a Pediatric Hospital in Morelia, México. Am J Trop Med Hyg. 2014;91:537-40. https://doi.org/10.4269/ajtmh.13-0535
Núñez FA, González OM, González I, Escobedo AA, Cordoví RA. Intestinal Coccidia in Cuban pediatric patients with diarrhea. Mem Inst Oswaldo Cruz. 2003;98:539-42. https://doi.org/10.1590/s0074-02762003000400021
Thivierge K, Iqbal A, Dixon B, Dion R, Levesque B, Cantin P, et al. Cryptosporidium hominis is a newly recognized pathogen in the Arctic Region of Nunavik, Canada: Molecular characterization of an outbreak. PLoS Negl Trop Dis. 2016;10:e0004534. https://doi.org/10.1371/journal.pntd.0004534
Dey A, Ghoshal U, Agarwal V, Ghoshal U. Genotyping of Cryptosporidium species and their clinical manifestations in patients with renal transplantation and human immunodeficiency virus infection. J Pathog. 2016;2016:2623602. https://doi.org/10.1155/2016/2623602
Mor SM, Tumwine JK, Ndeezi G, Srinivasan MG, Kaddu-Mulindwa DH, Tzipori S, et al. Respiratory cryptosporidiosis in HIV-seronegative children in Uganda: Potential for respiratory transmission. Clin Infect Dis. 2010;50:1366-72. https://doi.org/10.1086/652140
Mor SM, Ascolillo LR, Nakato R, Ndeezi G, Tumwine JK, Okwera A. Expectoration of Cryptosporidium parasites in sputum of human immunodeficiency virus–positive and –negative adults. Am J Trop Med Hyg. 2018;98:1086-90. https://doi.org/10.4269/ajtmh.17-0741
Rivero-Rodríguez Z, Hernández A, Bracho A, Salazar S, Villalobos R. Prevalencia de microsporidios y otros enteroparásitos en pacientes con VIH positivo de Maracaibo, Venezuela. Biomédica. 2013;33:538-45. https://doi.org/10.7705/biomedica.v33i4.1468
Saramago-Peralta RH, Velásquez JN, de Souza-Cunha F, Pantano ML, Campos-Sodré F, da Silva S, et al. Genetic diversity of Cryptosporidium identified in clinical samples from cities in Brazil and Argentina. Mem Inst Oswaldo Cruz. 2016;111:30-6. https://doi.org/10.1590/0074-02760150303
Yang Y, Zhou Y, Cheng W, Pan X, Xiao P, Shi Y, et al. Prevalence and determinants of Cryptosporidium infection in an underdeveloped rural region of Southwestern China. Am J Trop Med Hyg. 2017;96:595-601. https://doi.org/10.4269/ajtmh.16-0732
Shafiei R, Najjari M, Kargar-Kheirabad A, Hatam G. Severe diarrhea due to Cystoisospora belli infection in an HTLV-1 woman. Iran J Parasitol. 2016;11:121-5.
Chappell CL, Okhuysen PC, Langer-Curry RC, Lupo PJ, Widmer G, Tzipori S. Cryptosporidium muris: Infectivity and illness in healthy adult volunteers. Am J Trop Med Hyg. 2015;92:50-5. https://doi.org/10.4269/ajtmh.14-0525
Woon S, Yang R, Ryan U, Boan P, Prentice D. Chronic Cystoisospora belli infection in an immunocompetent Myanmar refugee –microscopy is not sensitive enough. BMC Infect Dis. 2016;16:221-5. https://doi.org/10.1186/s12879-016-1558-3
Golan-Shaposhnik E, Abozaid S, Grossman T, Marva E, On A, Azrad M, et al. The prevalence of Cryptosporidium among children hospitalized because of gastrointestinal symptoms and the efficiency of diagnostic methods for Cryptosporidium. Am J Trop Med Hyg. 2019;101:160-3. https://doi.org/10.4269/ajtmh.19-0057
Fleece ME, Heptinstall J, Khan S, Kabir M, Herbein J, Haque R, et al. Evaluation of a rapid lateral flow point-of-care test for detection of Cryptosporidium. Am J Trop Med Hyg. 2016;95:840-1. https://doi.org/10.4269/ajtmh.16-0132
Vieira-Silva C, Simão-Ferreira M, Gonçalves-Pires M, Costa-Cruz JM. Detection of Cryptosporidium - specific coproantigen in human immunodeficiency virus/acquired immunodeficiency syndrome patients by using a commercially available immunoenzymatic assay. Mem Inst Oswaldo Cruz. 2003;98:1097-9.
https://doi.org/10.1590/s0074-02762003000800022
Ribeiro-Rolando R, da Silva S, Saramago-Peralta R, da Silva AJ, de Souza-Cunha F, Ribeiro-Bello A, et al. Detection and differentiation of Cryptosporidium by real-time polymerase chain reaction in stool samples from patients in Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2012;107:476-9. https://doi.org/10.1590/s0074-02762012000400006
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