Impact of health-related quality of life on pediatric patients who underwent hematopoietic stem cell transplantation in a Colombian institution
Abstract
Introduction: Hematopoietic stem cell transplantation is the curative option for some diseases and is increasing patient survival. The health-related quality of life in these patients is not systematically evaluated.
Objectives: The present study sought to describe the health-related quality of life and complications in children who underwent hematopoietic stem cell transplantation.
Materials and methods: A cross-sectional study was conducted on pediatric transplanted survivors. Health-related quality of life was measured using the KIDSCREEN-27 scale and Short Form-12 (SF-12) in patients between 8 and 14 years of age and those over 14 years, respectively. Statistical analysis was performed using STATA 12 software. We used the Rasch model person parameter estimates translated into T-values to score the questionnaire.
Results: A total of 42 children answered the questionnaires. The most frequent adverse events were chronic graft Vs. host disease and endocrine complications. According to European norm data in the KIDSCREEN-12 scale, scores for the school dimension and social and peer support were below the 50th. percentile. The group administered immunosuppressants had lower scores on the physical component of the SF-12™ scale.
Conclusions: In general, the KIDSCREEN-27 does appear to suggest some quality-of-life deficit in younger children. The scales showed reliability in this population.
Downloads
References
Berbis J, Michel G, Chastagner P, Sirvent N, Demeocq F, Plantaz D, et al. A French cohort of childhood leukemia survivors: Impact of hematopoietic stem cell transplantation on health status and quality of life. Biol Blood Marrow Transplant. 2013;19:1065-72. https://doi.org/10.1016/j.bbmt.2013.04.015
Bhatia S. Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up. Expert Rev Hematol. 2011;4:437-54. https://doi.org/10.1586/ehm.11.39
Grupo de Trabajo sobre Calidad de Vida en la Infancia. Calidad de vida relacionada con la salud en pediatría. Instrumentos utilizados para su evaluación. Arch Argent Pediatr. 2014;112:571-6. https://doi.org/10.5546/aap.2014.571
Vinaccia Alpi S, Quiceno JM. Calidad de vida relacionada con la salud y enfermedad cronica: estudios colombianos. Psychologia. Avances de la Disciplina. 2012;6:123-36.
Cádiz DV, Urzúa MA, Campbell BM. Calidad de vida en niños y adolescents sobrevivientes de leucemia linfoblástica aguda. Rev Chil Pediatr. 2011;82:113-21. https://doi.org/10.4067/S0370-41062011000200005
Urzúa MA. Calidad de vida relacionada con la salud: elementos conceptuales. Rev Med Chil. 2010;138:358-65. https://doi.org/10.4067/S0034-98872010000300017
González-De-Dios J. Calidad de vida relacionada con la salud: conocer e implementar en la toma de decisiones basada en pruebas en pediatría. An Pediatr. 2004;60:507-13.
Quintero CA, Lugo LH, García HI, Sánchez A. Validación del cuestionario KIDSCREEN-27 de calidad de vida relacionada con la salud en niños y adolescentes de Medellín, Colombia. Rev Colomb Psiquiatr. 2011;40:470-87.
Harju E, Roser K, Dehler S, Michel G. Health-related quality of life in adolescent and young adult cancer survivors. Support Care Cancer. 2018;26:3099-110. https://doi.org/10.1007/s00520-018-4151-z
Oviedo HC, Campo-Arias A. Aproximación al uso del coeficiente alfa de Cronbach. Rev Colomb Psiquiatr. 2005;34:572-80.
The KIDSCREEN Group Europe. The KIDSCREEN Questionnaires –Quality of life questionnaires for children and adolescents. Handbook. Lengerich: Pabst Science Publishers; 2006.
Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey. Med Care. 1996;34220-33.
Spruit JL, Prince-Paul M. Palliative care services in pediatric oncology. Ann Palliat Med. 2019;8:S49-57. https://doi.org/110.21037/apm.2018.05.04
Namisango E, Bristowe K, Murtagh FEM, Downing J, Powell RA, Abas M, et al. Towards person-centred quality care for children with life-limiting and life-threatening illness: Selfreported symptoms, concerns and priority outcomes from a multi-country qualitative study. Palliat Med. 2020;34:319-35. https://doi.org/10.1177/0269216319900137
Christian BJ. Translational research – Promoting quality of life in children through health screening and improved management of chronic conditions. J Pediatr Nurs. 2019;44:123-6. https://doi.org/10.1016/j.pedn.2018.12.012
Liu YM, Jaing TH, Chen YC, Tang ST, Li CY, Wen YC, et al. Quality of life after hematopoietic stem cell transplantation in pediatric survivors. Cancer Nurs. 2016;39:502-9. https://doi.org/10.1097/NCC.0000000000000339
Vélez CM, Villada-Ramírez AC, Arias ACA, Eslava-Schmalbach JH. Rasch model in the validation of the Paediatric Quality of Life InventoryTM 4.0 (PedsQL 4.0TM) in Colombian children and adolescents. Rev Colomb Psiquiatr. 2016;45:186-93.
Jensen JN, Gøtzsche F, Heilmann C, Sengeløv H, Adamsen L, Christensen KB, et al. Physical and emotional well-being of survivors of childhood and young adult allo-SCT –A Danish national cohort study. Pediatr Transplant. 2016;20:697-706. https://doi.org/10.1111/petr.12713
Kurosawa S, Yamaguchi T, Mori T, Kanamori H, Onishi Y, Emi N, et al. Patient-reported quality of life after allogeneic hematopoietic cell transplantation or chemotherapy for acute leukemia. Bone Marrow Transplant. 2015;50:1241-9. https://doi.org/10.1038/bmt.2015.137
Schultz KAP, Chen L, Chen Z, Kawashima T, Oeffinger KC, Woods WG, et al. Health conditions and quality of life in survivors of childhood acute myeloid leukemia comparing post remission chemotherapy to BMT: A report from the children’s oncology group. Pediatr Blood Cancer. 2014;61:729-36. https://doi.org/10.1002/pbc.24881
Wengenroth L, Gianinazzi ME, Rueegg CS, Lüer S, Bergstraesser E, Kuehni CE, et al. Health-related quality of life in young survivors of childhood cancer. Qual Life Res. 2015;24:2151-61. https://doi.org/10.1007/s11136-015-0961-3
Dóro MP, Pasquini R, Löhr SS. A functional assessment of adolescents who were recipients of bone marrow transplantation: A prospective study. Rev Bras Hematol Hemoter. 2003;25:5-15. https://doi.org/10.1590/S1516-84842003000100003
Dorantes-Acosta E, Villasís-Keever MÁ, Zapata-Tarrés M, Arias-Gómez J, Escamilla-Núñez A, Miranda-Lora AL, et al. Calidad de vida de niños mexicanos con leucemia linfoblástica aguda atendidos por el seguro popular. Bol Med Hosp Infant Mex. 2012;69:242-54.
Tuesca-Molina R. La calidad de vida, su importancia y cómo medirla. Salud Uninorte. 2005;21:76-86.
Oberg JA, Bender JG, Morris E, Harrison L, Basch CE, Garvin JH, et al. Pediatric allo-SCT for malignant and non-malignant diseases: Impact on health-related quality of life outcomes. Bone Marrow Transplant. 2013;48:787-93. https://doi.org/10.1038/bmt.2012.217
Rodday AM, Terrin N, Parsons SK. Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: A longitudinal study. Health Qual Life Outcomes. 2013;11:26. https://doi.org/10.1186/1477-7525-11-26
Some similar items:
- María Isabel García, Camila Céspedes, Paola Durán , Catalina Forero, Mauricio Coll , Evaluation of the quality of life in children and adolescents with type 1 diabetes in two health institutions, Bogotá, D. C., Colombia , Biomedica: Vol. 43 No. 1 (2023)
- Ernesto Durán-Strauch, A difficult time for children’s health and wellbeing , Biomedica: Vol. 41 No. 3 (2021)
- Sandra Piñeros-Ortiz, Jaime Moreno-Chaparro, Nathaly Garzón-Orjuela, Zulma Urrego-Mendoza, Daniel Samacá-Samacá, Javier Eslava-Schmalbach, Mental health consequences of armed conflicts in children and adolescents: An overview of literature reviews , Biomedica: Vol. 41 No. 3 (2021)
- María del Pilar Chaves, Julián Alfredo Fernández, Isabel Ospina, Myriam Consuelo López, Ligia Moncada, Patricia Reyes, Giardia duodenalis prevalence and associated risk factors in preschool and school-age children of rural Colombia , Biomedica: Vol. 27 No. 3 (2007)
- Rosa Magdalena Uscátegui, Adriana M. Correa, Jaime Carmona-Fonseca, Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria , Biomedica: Vol. 29 No. 2 (2009)
- Andrés Leonardo González, Ruth Aralí Martínez, Luis Ángel Villar, Clinical evolution of dengue in hospitalized patients , Biomedica: Vol. 28 No. 4 (2008)
- Alejandro Padilla-Guzmán, Olga L. Prado, David Ballesteros, Viviana Rivera, Yessica Bravo, Luisa Murillo , Sandra Narváez, Jessica M. Forero, A hospital management algorithm for acute poisoning by Paraquat® in a pediatric population, a series of cases , Biomedica: Vol. 44 No. 1 (2024)
- Ligia Inés Moncada, Sandra Milena Rios, Julián Alfredo Fernández, Fabio Rivas, María Luz Sáenz, Pediculosis prevalence and associated risk factors in a nursery school, Bogotá, Colombia , Biomedica: Vol. 28 No. 2 (2008)
- Elsa Villarreal, Yibby Forero, Elpidia Poveda, César Baracaldo, Elizabeth López, Cardiovascular risk markers in schoolchildren from five provinces of eastern Colombia , Biomedica: Vol. 28 No. 1 (2008)
- Elpidia Poveda, Ney E. Callas, César M. Baracaldo, Carlina Castillo, Patricia Hernández, Leptin levels in school age children associated with anthropometric measurements and lipid profiles , Biomedica: Vol. 27 No. 4 (2007)
Copyright (c) 2022 Biomedica
This work is licensed under a Creative Commons Attribution 4.0 International License.
Funding data
-
Fundación Valle del Lili
Grant numbers N.A
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
