Severe adenovirus infection outbreak in Colombia: Experience from a tertiary pediatric hospital in 2022
Abstract
Introduction. During the SARS-CoV-2 pandemic, many countries experienced decreased respiratory virus circulation, followed by an out-of-season outbreak. In a pediatric hospital in Colombia, we observed a surge in severe adenovirus infections, leading to concerns about the impact of eased public health restrictions and immune debt in children under five years old.
Objective. To describe the clinical characteristics of patients with severe adenovirus infection in a pediatric hospital in Colombia.
Materials and methods. We reviewed the data of 227 patients with severe adenovirus infection at the Fundación Hospital Pediátrico La Misericordia.
Results. A total of 196 patients were included in this study. The median age was two years, and 62% were male. Adenoviruses were isolated from all patients’ samples. Ninetyseven percent were admitted to the pediatric intensive care unit, 94% required respiratory support, and the in-hospital lethality rate was 11%.
Conclusion. In 2022, there was an outbreak of severe adenovirus infections, affecting mainly children under five years of age, with higher-than-usual mortality.
Downloads
References
Gutiérrez-Tobar IF, Beltrán-Arroyave C, Díaz A, Londoño JP, Jiménez KL, Zamora CG, et al. Adenovirus respiratory infections post pandemic in Colombia: An old enemy with increased severity in pediatric population? Pediatr Infect Dis J. 2023;42:e133-4. https://doi.org/10.1097/INF.0000000000003827
Shi T, Chen C, Fan H, Yu M, Li M, Yang D, et al. Impact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia. BMC Pulm Med. 2023;23:41. https://doi.org/10.1186/s12890-022-02284-5
Cohen R, Levy C, Rybak A, Angoulvant F, Ouldali N, Grimprel E. Immune debt: Recrudescence of disease and confirmation of a contested concept. Infect Dis Now. 2023;53:104638. https://doi.org/10.1016/j.idnow.2022.12.003
Rodríguez C, Rodríguez AD, Cárdenas A, Quilaguy I, Mayorga L, Falla L, et al. Infección por virus sincitial respiratorio y por adenovirus en una población de niños colombianos menores de 3 años hospitalizados por infección respiratoria aguda baja. Revista Médica Sanitas. 2013;16:68-76.
Herrera D, De la Hoz F, Mariño C, Ramírez E, López J, Vélez C. Adenovirus en niños menores de cinco años. Patrones de circulación, características clínicas y epidemiológicas en Colombia, 1997-2003. Revista de Salud Pública. 2007;9:420-9.
Some similar items:
- Alvaro Vallejos, Adverse reactions by antibiotics in a pediatric and neonatal intensive care unit located in Bogotá, Colombia , Biomedica: Vol. 27 No. 1 (2007)
- Myrtha Arango, Elizabeth Castañeda, Clara Inés Agudelo, Catalina De Bedout, Carlos Andrés Agudelo, Angela Tobón, Melva Linares, Yorlady Valencia, Ángela Restrepo, The Colombian Histoplasmosis Study Group, Histoplasmosis: results of the Colombian National Survey, 1992-2008 , Biomedica: Vol. 31 No. 3 (2011)
- Jhon Carlos Castaño, Fidel Ángel Núñez, María Mercedes González, Germán Téllez, María Isabel Giraldo, First case report of Mammomonogamus (Syngamus) laryngeus human infection in Colombia , Biomedica: Vol. 26 No. 3 (2006)
- Ángela M. Pedraza, Carlos E. Rodríguez-Martínez, Ranniery Acuña, Initial validation of a scale to measure the burden for parents/caregivers of children with asthma and factors associated with this burden in a population of asthmatic children , Biomedica: Vol. 33 No. 3 (2013)
- Angela Méndez, Gerardo González, Dengue haemorrhagic fever in children: ten years of clinical experience. , Biomedica: Vol. 23 No. 2 (2003)
- María Victoria Ovalle, Clara I. Agudelo, Nélida Muñoz, Elizabeth Castañeda, Carmen R. Gallego, Sandra Núñez, Edilma Jaramillo, Vianey Emilce Portilla, Mercedes Cano, Martha Gartner, María Helena Alvarez, Gladys Mora, Patricia Rincón, Martha Uzeta, Surveillance of Haemophilus influenzae serotypes and antimicrobial resistance in Colombia, 1994-2002. , Biomedica: Vol. 23 No. 2 (2003)
- John Fredy Nieto-Ríos, Mónica Zuluaga-Quintero, Arbey Aristizábal-Alzate, Catalina Ocampo-Kohn, Lina María Serna-Higuita, Isabel Cristina Ramírez-Sánchez, Gustavo Adolfo Zuluaga-Valencia, Severe hypoxemic respiratory failure caused by Pneumocystis jirovecii in a late kidney transplant recipient , Biomedica: Vol. 38 No. 1 (2018)
- Nora Alejandra Zuluaga, Adriana Osorno, Alba Lozano, Oscar Villada, Clinical and metabolic effect of a multidisciplinary intervention through a comprehensive care program for children and adolescents with obesity , Biomedica: Vol. 40 No. 1 (2020)
- Adson Martins, Samara Santos, Claudia Lisboa, Tânia Barros, Tereza Ribeiro, Hugo da Costa-Ribeiro Jr., Ângela Mattos, Patrícia Mendes, Carlos Mendes, Edna Souza, Ana Amor, Neci Soares, Márcia Cristina Aquino Teixeira, Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea , Biomedica: Vol. 44 No. 1 (2024)
- Pilar Calmarza, Rasha Isabel Pérez-Ajami, Carlos Prieto-López, Alba Gallego-Rojo, Celia García-Carro, Graciela María Lou-Francés, Glycemic control and study of lipid and bone metabolism in type 1 diabetic children , Biomedica: Vol. 44 No. Sp. 1 (2024): Enfermedades crónicas no transmisibles
Copyright (c) 2024 Biomedica
This work is licensed under a Creative Commons Attribution 4.0 International License.
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |