Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population
Abstract
Introduction: Obesity results from interaction between genetic and environmental risk factors.
Objective: To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population.
Materials and methods: A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms (UCP3-rs1800849, FTO-rs17817449, and CAPN10-rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet.
Results: A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals.
Conclusions: In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.
Downloads
Some similar items:
- Nora Elena Múnera, Rosa Magdalena Uscátegui, Beatriz Elena Parra, Luz Mariela Manjarrés, Fredy Patiño, Claudia María Velásquez, Alejandro Estrada, Gabriel Bedoya, Vicky Parra, Angélica María Muñoz, Ana Carolina Orozco, Gloria María Agudelo, Environmental risk factors and metabolic syndrome components in overweight youngsters , Biomedica: Vol. 32 No. 1 (2012)
- Constanza Pardo, Marion Piñeros, Teenage tobacco consumption in five Colombian cities , Biomedica: Vol. 30 No. 4 (2010)
- Elpidia Poveda, Diana Giraldo, Yibby Forero, Carlos Mendivil, Self-reported physical activity in comparison with anthropometric body fat indicators in school children , Biomedica: Vol. 28 No. 3 (2008)
- Greta Rodríguez-Arroyo, Irene Paradisi, Merlyn Vívenes-Lugo, Dinorah Castro-Guerra, Álvaro Rodríguez-Larralde, LEP, LDLR and APOA4 gene polymorphisms and their relationship with the risk of overweight, obesity and chronic diseases in adults of the State of Sucre, Venezuela , Biomedica: Vol. 36 No. 1 (2016)
- Doris Cardona, Ángela María Segura, Adriana Espinosa, Alejandra Segura, Homicide and suicide in 15 to 24 year-old people in Colombia, 1998-2008 , Biomedica: Vol. 33 No. 4 (2013)
- Ana Cecilia Aguilar, Alberto Pradilla, Mildrey Mosquera, Ana Beatriz Gracia, José Guillermo Ortega, Jaime Humberto Leiva, Robinson Ramírez-Vélez, Percentile values for physical condition for Cali, Colombian children and adolescents , Biomedica: Vol. 31 No. 2 (2011)
- Beatriz Eugenia Alvarado, Luis Reinel Vásquez, Social determinants, feeding practices and nutritional consequences of intestinal parasitism in young children. , Biomedica: Vol. 26 No. 1 (2006)
- Juan Manuel Anaya, Mauricio Uribe, Adriana Pérez, Juan F. Sánchez, Luis F. Pinto, José F. Molina, María C. Londoño, Martha E. Cadavid, Gustavo Matute, Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia. , Biomedica: Vol. 23 No. 3 (2003)
- Elizabeth Borrero, Gabriel Carrasquilla, Neal Alexander, Decentralization and health system reform: What is their impact on malaria incidence in Colombian municipalities? , Biomedica: Vol. 32 (2012): Suplemento 1, Malaria
- Mauricio Beltrán, María Cristina Navas, María Patricia Arbeláez, Jorge Donado, Sergio Jaramillo, Fernando De la Hoz, Cecilia Estrada, Lucía del Pilar Cortés, Amalia de Maldonado, Gloria Rey, Seroprevalence of hepatitis B virus and human immunodeficiency virus infection in a population of multiply-transfused patients in Colombia , Biomedica: Vol. 29 No. 2 (2009)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |