Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calyces
Keywords:
Solanaceae, Physalis, inflammation, anti-inflammatory agents, plants medicinal
Abstract
Introduction. Cape gooseberry calyces (Physalis peruviana) have been used in folk medicine for their medicinal properties including anticancer, antimycobacterial, antipyretic, diuretic, immunomodulatory and antiinflammatory properties.Objective. The antiinflammatory effect was evaluated for extracts and fractions obtained from Physalis peruviana calyces in a mice model of acute inflammation. The fractions responsible for antiinflammatory activity were extracted for possible identification.
Materials and Methods. The Physalis peruviana calyces were extracted by percolation with organic solvents. The primary hydroalcoholic fraction was purified by column chromatography. The antiinflammatory effect of extracts and fractions was evaluated using the 12-Otetradecanoylphorbol-13-acetate-induced mouse model of ear edema.
Results. Thirty-eight secondary fractions were obtained by column chromatography of primary hydroalcoholic fraction. Six fractions, evaluated in 12-O-tetradecanoylphorbol-13-acetateinduced inflammation assay, showed significant antiinflammatory activity (p<0.05). The major fraction, Pp-D28-LF, showed a significant dose-dependent response at doses over 250 μg/ear.
Conclusion. The antiinflammatory activity attributed to Physalis peruviana calyces was confirmed and validated its use in folk medicine. Fractions responsible for the antiinflammatory action were identified and seem promising for phytomedicinal development. Further studies are needed to isolate and identify the active constituents of these fractions as well as to ascertain the mechanisms involved in the antiinflammatory effect.
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References
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4. Wu SJ, Tsai JY, Chang SP, Lin DL, Wang SS, Huang SN et al. Supercritical carbon dioxide extract exhibits enhance antioxidant and anti-inflammatory activities of Physalis peruviana. J Ethnopharmacol 2006;108:407-13.
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7. Wu SJ, Ng LT, Lin DL, Huang SN, Wang SS, Lin CC. Physalis peruviana extract induces in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway. Cancer
Lett 2004;215:199-208.
8. Yesilada E, Üstun O, Sezik E, Takaishi Y, Ono Y, Honda G. Inhibitory effects of Turkish folk remedies on inflammatory cytokine: interleukin-1a, interleukin-1b and tumour necrosis factor a. J Ethnopharmacol 1997;58:59-73.
9. Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan SK, Prakash VR. Evaluation of antiinflammatory activity of Pongamia pinnata leaves in rats. J Ethnopharmacol 2001;78:151-7.
10. Choi EM, Hwang J. Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida. J Ethnopharmacol 2003;89:171-5.
11. Sautebin L. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia 2000;71(Suppl. 1):S48-57.
12. Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br J Pharmacol 2003;139:209-18.
13. Maity S, Ukil A, Karmakar S, Datta N, Chaudhuri T, Vedasiromoni JR et al. Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur J Pharmacol 2003;470:103-12.
14. De Young LM, Kheifets JB, Ballaron SJ, Young JM. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separated and can be differentially modulated by pharmacologic agents. Agents Actions 1989;26:335-41.
15. Payá M, Ferrándiz ML, Sanz MJ, Bustos G, Blasco R, Ríos JL et al. Study of the antioedema activity of some seaweed and sponge extracts from the mediterranean coast in mice. Phytother Res
1993;7:159-62.
16. Jiménez-Estrada M, Chilpa RR, Apan TR, Lledias F, Hansberg W, Arrieta D et al. Anti-inflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositum. J Ethnopharmacol 2006;105:34-8.
17. Recio MC, Cérda-Nicolas M, Potterat O, Hamburger M, Rios JL. Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and Tryptanthrin. Planta Med 2006;72:539-46.
18. García MD, Fernandez M, Alvarez A, Saenz M. Antinociceptive and anti-inflammatory effect of the aqueous extract from leaves of Pimenta racemosa var. ozua (Mirtaceae). J Ethnopharmacol 2004;91:69-73.
2. Bastos GN, Santos AR, Ferrerira VM, Costa AM, Bispo CI, Silveira AJ et al. Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice. J Ethnopharmacol 2006;103:241-5.
3. Wu SJ, Ng LT, Huang YM, Lin DL, Wang SS, Huang SN et al. Antioxidant activities of Physalis peruviana. Biol Pharm Bull 2005;28:963-6.
4. Wu SJ, Tsai JY, Chang SP, Lin DL, Wang SS, Huang SN et al. Supercritical carbon dioxide extract exhibits enhance antioxidant and anti-inflammatory activities of Physalis peruviana. J Ethnopharmacol 2006;108:407-13.
5. Mayorga H, Duque C, Knapp H, Winterhalter P. Hydroxyester disaccharides from fruits of cape gooseberry (Physalis peruviana) . Phytochemistry 2002;59:439-45.
6. Pérez-Castorena AL, García M, Martínez M, Maldonado E. Physalins from Physalis solanaceus. Biochem Syst Ecol 2004;32:1231-4.
7. Wu SJ, Ng LT, Lin DL, Huang SN, Wang SS, Lin CC. Physalis peruviana extract induces in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway. Cancer
Lett 2004;215:199-208.
8. Yesilada E, Üstun O, Sezik E, Takaishi Y, Ono Y, Honda G. Inhibitory effects of Turkish folk remedies on inflammatory cytokine: interleukin-1a, interleukin-1b and tumour necrosis factor a. J Ethnopharmacol 1997;58:59-73.
9. Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan SK, Prakash VR. Evaluation of antiinflammatory activity of Pongamia pinnata leaves in rats. J Ethnopharmacol 2001;78:151-7.
10. Choi EM, Hwang J. Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida. J Ethnopharmacol 2003;89:171-5.
11. Sautebin L. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia 2000;71(Suppl. 1):S48-57.
12. Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br J Pharmacol 2003;139:209-18.
13. Maity S, Ukil A, Karmakar S, Datta N, Chaudhuri T, Vedasiromoni JR et al. Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur J Pharmacol 2003;470:103-12.
14. De Young LM, Kheifets JB, Ballaron SJ, Young JM. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separated and can be differentially modulated by pharmacologic agents. Agents Actions 1989;26:335-41.
15. Payá M, Ferrándiz ML, Sanz MJ, Bustos G, Blasco R, Ríos JL et al. Study of the antioedema activity of some seaweed and sponge extracts from the mediterranean coast in mice. Phytother Res
1993;7:159-62.
16. Jiménez-Estrada M, Chilpa RR, Apan TR, Lledias F, Hansberg W, Arrieta D et al. Anti-inflammatory activity of cacalol and cacalone sesquiterpenes isolated from Psacalium decompositum. J Ethnopharmacol 2006;105:34-8.
17. Recio MC, Cérda-Nicolas M, Potterat O, Hamburger M, Rios JL. Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and Tryptanthrin. Planta Med 2006;72:539-46.
18. García MD, Fernandez M, Alvarez A, Saenz M. Antinociceptive and anti-inflammatory effect of the aqueous extract from leaves of Pimenta racemosa var. ozua (Mirtaceae). J Ethnopharmacol 2004;91:69-73.
How to Cite
1.
Franco LA, Matiz GE, Calle J, Pinzón R, Ospina LF. Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calyces. biomedica [Internet]. 2007 Mar. 1 [cited 2024 May 18];27(1):110-5. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/237
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2007-03-01
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