Determination of HLA-A, -B and -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014
Abstract
Introduction: Genes encoding for human leukocyte antigens (HLA) are highly polymorphic and of great importance in organ transplantation procedures, as determining allelic frequencies in defined populations is taken into account among the scientific criteria for organ allocation.
Objective: The objective of this study was to establish the antigen HLA-A, -B, and -DRB1 haplotype frequencies in organ donors representative of the Colombian population after brain death.
Materials and methods: We conducted a descriptive retrospective study involving 2,506 cadaveric organ donors including an allelic and haplotype analysis of HLA-A, -B and -DRB1; we also determined the Hardy-Weinberg equilibrium.
Results: We identified 21, 43 and 15 allelic loci for groups A*, B* and DRB1*, respectively. We detected 1,268 HLA-A, -B and -DR, 409 HLA-A-B, 383 HLA-DR-B, and 218 HLA-A-DR haplotypes. The three loci were found to be in Hardy-Weinberg equilibrium between the number of heterozygotes observed and the expected number, with p values of <0.05.
Conclusions: This study provides information on the allelic distribution of HLA class I and II in organ donors from the six regions in which Colombia is structurally divided to provide transplant services.
Downloads
References
Doxiadis II. Compatibility and kidney transplantation: The way to go. Front Immunol. 2012;14;3:111. http://dx.doi.org/10.3389/fimmu.2012.00111
Clark B, Unsworth DJ. HLA and kidney transplantation. J Clin Pathol. 2010;63:21-5. http://dx.doi.org/10.1136/jcp.2009.072785
Aydingoz SE, Takemoto SK, Pinsky BW, Salvalaggio PR, Lentine KL, Willoughby L, et al. The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage. Hum Immunol. 2007;68:491-9. http://dx.doi.org/10.1016/j.humimm.2007.02.004
Laperrousaz S, Tiercy J, Villard J, Ferrari S. HLA and non-HLA polymorphisms in renal transplantation. Swiss Med Wkly. 2012;142:368-79. http://dx.doi.org/10.4414/smw.2012.13668
Ministerio de Salud y Protección Social. Decreto 2493. Diario Oficial N°. 45631. Bogotá: Imprenta Nacional de Colombia; 2004.
Ministerio de Salud y Protección Social. Resolución 2640. Diario Oficial N° 46007. Bogotá: Imprenta Nacional de Colombia; 2005.
Instituto Nacional de Salud. Informe Red Donación y Trasplante, 2010. Bogotá: INS; 2010. Fecha de consulta: 10 de junio de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe%20FinalRed%20D%20Tx%20-%202010.pdf
Instituto Nacional de Salud. Informe anual Red de Donación y Trasplantes, 2011. Bogotá: INS; 2011. Fecha de consulta: 10 de junio de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe%20Red%20Donacion%20y%20Trasplantes%20%20Vol%201%202011.pdf
Instituto Nacional de Salud. Informe anual Red de Donación y Trasplantes, 2012. Bogotá: INS; 2012. Fecha de consulta: 10 de junio de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe_Red%20donacion%20y%20trasplantes%20Vol2_2012.pdf
Instituto Nacional de Salud. Informe anual Red de Donación y Trasplantes, 2013. Bogotá: INS; 2013. Fecha de consulta: 10 junio 2015. Disponible en: http://www.
ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/INFORME%20ANUAL%202013%20RED%20DE%20DONACION%20Y%20TRASPLANTES.%20Vol%2003.pdf.
Rodríguez LM, Giraldo MC, García N, Velásquez L, París SC, Álvarez CM, et al. Frecuencias alélicas, genotípicas y haplotípicas HLA-A, HLA-B, HLA-DRB1 en donantes fallecidos, Medellín, Colombia. Biomédica. 2007;27:537-47. http://dx.doi.org/10.7705/biomedica.v27i4.172
Ossa H, Manrique A, Quintanilla S, Peña A. Polimorfismos del sistema HLA (loci A*, B* y DRB1*) en población colombiana. NOVA. 2007;5:25-30.
Bermeo S, Guerra M, Ostos H. Frecuencias de HLA-A-B y DRB1 en una población de Huila, Colombia. Revista Facultad de Salud. 2010;2:9-19.
Arias Y, Castro M, Ríos M, López J, Echeverry S, Martínez O, et al. Analysis of HLA-A, HLA-B, HLA-DRB1 allelic, genotypic, and haplotypic frequencies in Colombian population. Colombia Médica. 2010;41:336-43.
Bengochea M, Álvarez I, Hidalgo PC, Cabrera A, Senatore O, Toledo R, et al. HLA-A, -B, -DR en receptores de trasplante de medula ósea en Uruguay. Rev Med Uruguay. 2003;19:149-58.
Alfaro EL, Dipierri JE, Gutiérrez N, Vullo CM. Frecuencias génicas y haplóticas del sistema HLA en el noroeste argentino. Antropo. 2004;6:15-23.
Weir BS. Genetic Data Analysis II. Sunderland, MA: Sinauer Associates; 1996.
de Pablo R, Beraún Y, Nieto A, Calzada JE, Rementería MC, Sanz L, et al. HLA class I and class II allele distribution in the Peruvian population. Tissue Antigens. 2000;56507-14. http://dx.doi.org/10.1034/j.1399-0039.2000.560604.x
Cao K, Hollenbach J, Shi X, Shi W, Chopek M, Fernández-Viña MA. Analysis of the frequencies of HLA-A, B and C alleles and haplotypes in the five mayor ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Hum Inmunol. 2000;62:1009-30. http://dx.doi.org/10.1016/S0198-8859(01)00298-1
Cao K, Hollenbach JA, Shi XJ, Shi WX, Chopek M, Fernández-Viña MA. HLA-A,-B and Cw allele frequencies in Hispanic population from the USA. Hum Inmunol. 2004;65:1206-8. http://dx.doi.org/10.1016/j.humimm.2004.08.160
Cao k, Hollenbach J, Shi X, Shi W, Chopek M, Fernández-Viña MA. Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Hum Immunol. 2001;62:1009-30. http://dx.doi.org/10.1016/S0198-8859(01)00298-1
Mori M, Beatty PG, Graves M, Boucher KM, Milford EL. HLA gene and haplotype frequencies in the North American population: The National Marrow Donor Program Donor Registry 1. Transplantation. 1997;64:1017-27.
Middleton D, Williams F, Meenagh A, Daar AS, Gorodezky C, Hammond M, et al. Analysis of the distribution of HLA-A alleles in populations from five continents. Hum Immunol. 2000;61:1048-52. http://dx.doi.org/10.1016/S0198-8859(00)00178-6
Zachary AA, Steinberg AG, Bias WB, Leffell MS. The frequencies of HLA alleles and haplotypes and their distribution among donors and renal patients in the UNOS registry. Transplantation. 1996;62:272-83.
Arrunátegui A, Villegas A, Ocampo L, Rodríguez L, Abdelmounim B. Frecuencias alélicas, genotípicas y haplotípicas del sistema HLA clase I y II en donantes de una población del suroccidente colombiano. Acta Med Colomb. 2013;38:16-21.
Some similar items:
- Martha Ruiz, Isis Arias, Gloria Rolón, Enio Hernández, Pilar Garavito, Carlos Silvera-Redondo, APOE gene polymorphism analysis in Barranquilla, Colombia , Biomedica: Vol. 36 No. 1 (2016)
- Karime Osorio-Arango, Mauricio Beltrán-Durán, Yazmín Arias-Murillo, Franklyn Prieto, Adriana Robayo, Survival in renal transplant recipients in Colombia, 2008-2012 , Biomedica: Vol. 37 No. 2 (2017)
- Jorge A. Vega, Simón Villegas-Ospina, Wbeimar Aguilar-Jiménez, María T. Rugeles, Gabriel Bedoya, Wildeman Zapata, Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort , Biomedica: Vol. 37 No. 2 (2017)
- María Atencia, Angie Toro-Cantillo, Richard Hoyos-López, Genetic diversity and population structure of Anopheles triannulatus s. l. in the department of Córdoba, Colombia, using DNA barcoding , Biomedica: Vol. 38 No. Sup. 2 (2018): Suplemento 2, Medicina tropical
- Juan J. Yunis, Luis E. Acevedo, David S. Campo, Emilio J. Yunis, Geno-geographic origin of Y-specific STR haplotypes in a sample of Caucasian-Mestizo and African-descent male individuals from Colombia , Biomedica: Vol. 33 No. 3 (2013)
- Lucero Rengifo, Duverney Gaviria, Herman Serrano, APOE gene polymorphisms associated with Down syndrome in Colombian populations , Biomedica: Vol. 32 No. 2 (2012)
- Raúl Murillo, Ricardo Cendales, Carolina Wiesner, Marion Piñeros, Sandra Tovar, Effectiveness of cytology-based cervical cancer screening in the Colombian health system , Biomedica: Vol. 29 No. 3 (2009)
- Jaime E. Bernal, Martha Lucía Tamayo , Ignacio Briceño , Escilda Benavides , Newborn screening in Colombia: The experience of a private program in Bogotá , Biomedica: Vol. 44 No. 1 (2024)
- Andrés Páez, Gloria Rey, Carlos Agudelo, Alvaro Dulce, Edgar Parra, Hernando Díaz-Granados, Damaris Heredia, Luis Polo, Outbreak of urban rabies transmitted by dogs in Santa Marta, northern Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Patricia Escobar, Katherine Paola Luna, Indira Paola Hernández, César Mauricio Rueda, María Magdalena Zorro, Simon L. Croft, In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole , Biomedica: Vol. 29 No. 3 (2009)
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
