Severe disseminated acute toxoplasmosis in an adult immunocompetent patient from the Colombian Pacific

Armando Daniel Cortés, Natalia Aguirre, .

Keywords: Toxoplasma, toxoplasmosis, myocarditis, Colombia

Abstract

We present the case of a 72-year-old immunocompetent patient from Chocó, Colombia, with a 12-day course of fever, headache, progressive neurological deterioration, and rapid evolution to multiorgan failure and death.
In the histopathological study of tissues obtained at necropsy, tissue cysts morphologically suggestive of being bradyzoites of Toxoplasma gondii were identified and confirmed by immunohistochemistry in heart, brain, and striated muscle.

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  • Armando Daniel Cortés Facultad de Salud, Departamento de Patología, Universidad del Valle, Cali, Colombia
  • Natalia Aguirre Programa de Anatomía Patológica y Patología Clínica, Universidad del Valle, Cali, Colombia

References

Sobanski V, Ajzenberg D, Delhaes L, Bautin N, Just N. Severe toxoplasmosis in immunocompetent hosts: Be aware of atypical strains. Am J Respir Crit Care Med. 2013;

:1143-5. https://doi.org/10.1164/rccm.201209-1635LE

Carme B, Bissuel F, Ajzenberg D, Bouyne R, Aznar C, Demar M, et al. Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana. J Clin Microbiol. 2002;40:4037-44. https://doi.org/10.1128/JCM.40.11.4037-4044.2002

Montoya J, Liesenfeld O. Toxoplasmosis. Lancet. 2004;363:1965-76. https://doi.org/10.1016/S0140-6736(04)16412-X

Saadatnia G, Golkar M. A review on human toxoplasmosis. Scand J Infect Dis. 2012;44:805-14. https://doi.org/10.3109/00365548.2012.693197

Nunura J, Endo S, Salazar D, Rodríguez A, Pereyra S, Solís H, et al. Disseminated toxoplasmosis in an immunocompetent patient from Peruvian Amazon. Rev Inst Med Trop Sao Paulo. 2010;52:107-10. https://doi.org/10.1590/S0036-46652010000200008

Montoya J. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis. 2002;185(Suppl.1):S73-82. https://doi.org/10.1086/338827

Petersen E, Ajzenberg D, Mandelbrot L, Gómez-Marín JE. Protozoan diseases: Toxoplasmosis. International Encyclopedia of Public Health. Second edition. Elsevier; 2017. p.114-32. https://doi.org/10.1016/B978-0-12-803678-5.00361-1

Demar M, Ajzenberg D, Maubon D, Djossou F, Panchoe D, Punwasi W, et al. Fatal outbreak of human toxoplasmosis along the Maroni River: Epidemiological, clinical, and parasitological aspects. Clin Infect Dis. 2007;45:88-95. https://doi.org/10.1086/521246

Leal F, Cavazzana C, Franco De Andrade H, Galisteo AJ Jr, de Mendonça JS, Kallas EG. Toxoplasma gondii pneumonia in immunocompetent subjects: Case report and review. Clin Infect Dis. 2007;44:e62-6. https://doi.org/10.1086/511871

Demar M, Hommel D, Djossou F, Peneau C, Boukhari R, Louvel D, et al. Acute toxoplasmoses in immunocompetent patients hospitalized in an intensive care unit in French Guiana. Clin Microbiol Infect. 2012;18:E221-31. https://doi.org/10.1111/j.1469-0691.2011.03648.x

Pena HF, Gennari SM, Dubey JP, Su C. Population structure and mouse-virulence of Toxoplasma gondii in Brazil. Int J Parasitol. 2008;38:561-9. https://doi.org/10.1016/j.ijpara.2007.09.004

De la Torre A, Sauer A, Bourcier T, Speeg-Schatz C, Ballonzoli L, Ajzenberg D, et al. Severe South American ocular toxoplasmosis is associated with decreased IFNgamma/IL-17A and increased IL-6/IL-13 intraocular levels. PLoS Neglected Trop Dis. 2013;7:e2541. https://doi.org/10.1371/journal.pntd.0002541

Pino L, Salinas J, López M. Description of an epidemic outbreak of acute toxoplasmosis in immunocompetent patients from Colombian Armed Forces during jungle operations. Infectio. 2009;13:83-91. https://doi.org/10.1016/S0123-9392(09)70729-5

Zea F. Inmunocompentencia en adultos: más que VIH negativo. Colombia Médica. 2016;47:176.

Darde ML. Toxoplasma gondii, “new” genotypes and virulence. Parasite. 2008;15:366-71. https://doi.org/10.1051/parasite/2008153366

How to Cite
1.
Cortés AD, Aguirre N. Severe disseminated acute toxoplasmosis in an adult immunocompetent patient from the Colombian Pacific. biomedica [Internet]. 2018 Aug. 1 [cited 2024 May 17];38(Sup. 2):19-23. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/4087

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Published
2018-08-01

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