Peripheral facial nerve lesion induced long-term dendritic retraction in pyramidal cortico-facial neurons
Abstract
Introduction. Little evidence is available concerning the morphological modifications of motor cortex neurons associated with peripheral nerve injuries, and the consequences of those injuries on postlesion functional recovery.
Objective. Dendritic branching of cortico-facial neurons was characterized with respect to the effects of irreversible facial nerve injury.
Materials and methods. Twenty-four adult male rats were distributed into four groups: sham (no lesion surgery), and dendritic assessment at 1, 3 and 5 weeks post surgery. Eighteen lesion animals underwent surgical transection of the mandibular and buccal branches of the facial nerve. Dendritic branching was examined by contralateral primary motor cortex slices stained with the Golgi-Cox technique. Layer V pyramidal (cortico-facial) neurons from sham and injured animals were reconstructed and their dendritic branching was compared using Sholl analysis.
Results. Animals with facial nerve lesions displayed persistent vibrissal paralysis throughout the fiveweek observation period. Compared with control animal neurons, cortico-facial pyramidal neurons
of surgically injured animals displayed shrinkage of their dendritic branches at statistically significant levels. This shrinkage persisted for at least five weeks after facial nerve injury.
Discussion. Irreversible facial motoneuron axonal damage induced persistent dendritic arborization shrinkage in contralateral cortico-facial neurons. This morphological reorganization may be the
physiological basis of functional sequelae observed in peripheral facial palsy patients.
Downloads
References
2. Moran LB, Graeber MB. The facial nerve axotomy model. Brain Res Brain Res Rev. 2004;44:154-78.
3. Carvell GE, Simons DJ. Biometric analyses of vibrissal tactile discrimination in the rat. J Neurosci. 1990;10:2638-48.
4. Grinevich V, Brecht M, Osten P. Monosynaptic pathway from rat vibrissa motor cortex to facial motor neurons revealed by lentivirus-based axonal tracing. J Neurosci. 2005;25:8250-8.
5. Hattox AM, Priest CA, Keller A. Functional circuitry involved in the regulation of whisker movements. J Comp Neurol. 2002;442:266-76.
6. Wineski LE. Facial morphology and vibrissal movement in the golden hamster. J Morphol. 1985;183:199-217.
7. Dörfl J. The innervation of the mystacial region of the white mouse. A topographical study. J Anat. 1985;142:173-84.
8. Rice FL, Mance A, Munger BL. A comparative light microscopic analysis of the sensory innervation of the mystacial pad: Innervation of vibrissal follicle-sinus complexes. J Comp Neurol. 1986;252:154-74.
9. Izraeli R, Porter LL. Vibrissal motor cortex in the rat: Connections with the barrel field. Exp Brain Res. 1995;104:41-54.
10. Farkas T, Perge J, Kis Z, Wolff JR, Toldi J. Facial nerve injury-induced disinhibition in the primary motor cortices of both hemispheres. Eur J Neurosci. 2000;12:2190-4.
11. Landgrebe M, Laskawi R, Wolff JR. Transient changes in cortical distribution of S100 proteins during reorganization of somatotopy in the primary motor cortex induced by facial nerve transection in adult rats. Eur J Neurosci. 2000;12:3729-40.
12. Toldi J, Farkas T, Perge J, Wolff JR. Facial nerve injury produces a latent somatosensory input through recruitment of the motor cortex in the rat. Neuroreport. 1999;10:2143-7.
13. Donoghue JP, Suner S, Sanes JN. Dynamic organization of primary motor cortex output to target muscles in adult rats II. Rapid reorganization following motor nerve lesions. Exp Brain Res. 1990;79:492-503.
14. Sanes JN, Wang J, Donoghue JP. Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations. Cereb Cortex. 1992;2:141-52.
15. Toldi J, Laskawi R, Landgrebe M, Wolff JR. Biphasic reorganization of somatotopy in the primary motor cortex follows facial nerve lesions in adult rats. Neurosci Lett. 1996;203:179-82.
16. Keller A, Weintraub ND, Miyashita E. Tactile experience determines the organization of movement representations in rat motor cortex. Neuroreport. 1996;7:2373-8.
17. Franchi G. Persistence of vibrissal motor representation following vibrissal pad deafferentation in adult rats. Exp Brain Res. 2001; 137:180-9.
18. Tailby C, Wright LL, Metha AB, Calford MB. Activitydependent maintenance and growth of dendrites in adult cortex. Proc Natl Acad Sci USA. 2005;102:4631-6.
19. Holtmaat A, Wilbrecht L, Knott GW, Welker E, Svoboda K. Experience-dependent and cell-type-specific spine growth in the neocortex. Nature. 2006;441:979-83.
20. Troncoso J, Múnera A. Cambios inducidos en la corteza motora primaria de la cara por lesión periférica del nervio facial contralateral. Acta Biológica Colombiana. 2008;13:220.
21. Alonso JR. Los métodos de Golgi. Salamanca: Ediciones Universidad de Salamanca; 1994.
22. Sholl DA. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat. 1953;87:387-406.
23. Bose M, Muñoz-Llancao P, Roychowdhury S, Nichols JA, Jakkamsetti V, Porter B, et al. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse. 2010;64:97-110.
24. Sánchez F, Gómez-Villalobos M de J, Juárez I, Quevedo L, Flores G. Dendritic morphology of neurons in medial prefrontal cortex, hippocampus, and nucleus accumbens in adult SH rats. Synapse. 2011;65:198-206.
25. Brännström T, Kellerth JO. Recovery of synapses in axotomized adult cat spinal motoneurons after reinnervation into muscle. Exp Brain Res. 1999;125:19-27.
26. Peyghambari F, Valojerdi MR, Tiraihi T. A morphometric study on the early stages of dendrite changes in the axotomized motoneuron of the spinal cord in newborn rats. Neurol Res. 2005;27:586-90.
27. Kobayashi NR, Bedard AM, Hincke MT, Tetzlaff W. Increased expression of BDNF and trkB mRNA in rat facial motoneurons after axotomy. Eur J Neurosci. 1996;8:1018-29.
28. Schmitt AB, Breuer S, Liman J, Buss A, Schlangen C, Pech K, et al. Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat. BMC Neurosci. 2003;4:8-20.
29. Gustafsson B. Changes in motoneurone electrical properties following axotomy. J Physiol. 1979;293:197-215.
30. Laiwand R, Werman R, Yarom Y. Electrophysiology of degenerating neurones in the vagal motor nucleus of the guinea-pig following axotomy. J Physiol. 1988;404:749-66.
31. Mentis GZ, Díaz E, Moran LB, Navarrete R. Early alterations in the electrophysiological properties of rat spinal motoneurones following neonatal axotomy. J Physiol. 2007;582:1141-61.
32. Kassa RM, Bentivoglio M, Mariotti R. Changes in the expression of P2X1 and P2X2 purinergic receptors in facial motoneurons after nerve lesions in rodents and correlation with motoneuron degeneration. Neurobiol Dis. 2007;25:121-33.
33. Mattsson P, Delfani K, Janson AM, Svensson M. Motor neuronal and glial apoptosis in the adult facial nucleus after intracranial nerve transection. J Neurosurg. 2006;104:411-8.
34. de la Cruz RR, Pastor AM, Delgado-García JM. Influence of the postsynaptic target on the functional properties of neurons in the adult mammalian central nervous system. Rev Neurosci. 1996;7:115-49.
35. Huntley GW. Correlation between patterns of horizontal connectivity and the extent of short-term representational plasticity in rat motor cortex. Cereb Cortex. 1997;7:143-56.
36. Mountcastle VB. The columnar organization of the neocortex. Brain. 1997;120:701-22.
37. Troncoso J, Múnera A, Delgado-García JM. Learningdependent potentiation in the vibrissal motor cortex is closely related to the acquisition of conditioned whisker responses in behaving mice. Learn Mem. 2007;14:84-93.
38. Pardal-Fernández JM, García-Álvarez G, Jerez-García P, Marco-Giner J, Almodóvar-Álvarez C. Parálisis facial periférica. Utilidad de la neurofisiología clínica. Rev Neurol. 2003;36:991-6.
39. Cárdenas CA, Múnera A. Changes in cutaneous sensibility in patients with Bell's palsy. FENS Abstr. 2010;5:136.
Some similar items:
- Jeimmy Cerón, Julieta Troncoso, Facial nerve injury-associated hippocampal microglial activation , Biomedica: Vol. 42 No. 1 (2022)
- Elpidia Poveda, Pilar Trujillo, Francisco Ruiz, Elizabeth Lopez, Glucose and insulin levels in Wistar rats submitted to high fat diet and treatment with mimetic leptin peptides , Biomedica: Vol. 28 No. 1 (2008)
- Mario Francisco Guerrero, Elements for the effective evaluation of natural products with possible antihypertensive effects , Biomedica: Vol. 29 No. 4 (2009)
- Lauro Figueroa, Francisco Díaz, Avelardo Camacho, Eliseo Díaz, Rolando Marvin, Activity induced by androsterone and hemisuccinate of androsterone on perfusion pressure and vascular resistance , Biomedica: Vol. 29 No. 4 (2009)
- Biviana Andrea Duque, Diego Aranzazu, Piedad Agudelo-Flórez, Andrés F. Londoño, Víctor H. Quiroz, Juan David Rodas, Rattus norvegicus as an indicator of circulation of Capillaria hepatica and Taenia taeniaeformis on a groceries trade center of Medellín, Colombia , Biomedica: Vol. 32 No. 4 (2012)
- Elpidia Poveda, Paola Ayala, Milena Rodríguez, Edgar Ordóñez, Cesar Baracaldo, Willman Delgado, Martha Guerra, Effects of vegetal oil supplementation on the lipid profile of Wistar rats . , Biomedica: Vol. 25 No. 1 (2005)
- Silvana Marisa Montenegro, María Cristina Tarrés, Juan Carlos Picena, Stella Maris Martínez, Feeding behavior and glycemic profile in two lines of rats with genetic diabetes. , Biomedica: Vol. 25 No. 4 (2005)
- Angélica María Sabogal, Cesar Augusto Arango, Gloria Patricia Cardona, Ángel Enrique Céspedes, Atorvastatin protects GABAergic and dopaminergic neurons in the nigrostriatal system in an experimental rat model of transient focal cerebral ischemia , Biomedica: Vol. 34 No. 2 (2014)
- Leticia Bequer, Tahiry Gómez, José Luis Molina, Daniel Artiles, Rosa Bermúdez, Sonia Clapés, Streptozotocin diabetogenic action in an experimental neonatal induction model , Biomedica: Vol. 36 No. 2 (2016)
- Jeimmy Cerón, Julieta Troncoso, Facial nerve injuries cause changes in central nervous system microglial cells , Biomedica: Vol. 36 No. 4 (2016)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |