Risk factors associated with pulmonary tuberculosis relapses in Cali, Colombia
Abstract
Introduction: Relapses in tuberculosis occur due to endogenous reactivations or exogenous reinfections and represent up to 27% of tuberculosis cases. Its importance lies in the risk of the appearance of multidrug-resistant Mycobacterium tuberculosis strains.
According to the reports published in 2011 by the Colombian Instituto Nacional de Salud, there were 572 relapse cases reported in the country, i.e., a rate of 4.9%. Data of the tuberculosis control program from the Secretaría de Salud Municipal in Cali reported a relapse rate of 6%, higher than the national one, during 2013 and 2014.
Objective: To determine the risk factors associated with relapse in patients with pulmonary tuberculosis in Cali.
Materials and methods: We conducted an observational, analytical, and case-control study (1:1), which comprised 81 cases of pulmonary tuberculosis relapses detected in 2013 and 2014. Additionally, we collected data on socio-demographic and clinical variables, as well as lifestyle and health services, to identify the potential risk factors associated with tuberculosis relapses. We used logistic regression to identify the risk factors.
Results: After adjustments for some variables, our multivariate logistic regression analysis showed that the body mass index (BMI) (OR=0.90, 95%CI: 0.81–0.99) and population density (OR=0.99, 95%CI: 0.98–1.00) were inversely associated with tuberculosis relapses. Alcohol consumption increased the likelihood of tuberculosis relapse (OR=5.56, 95%CI: 1.18–26.26).
Conclusions: Body mass index and population density were inversely associated with pulmonary tuberculosis relapses in Cali. On the contrary, alcohol consumption increased the likelihood of tuberculosis relapses.
Downloads
References
Fadul S, Martínez M, Pacheco O, Quijada H. Protocolo de Vigilancia en Salud Pública. Tuberculosis. Bogotá: Instituto Nacinal de Salud, Ministerio de Salud; 2016.
Patel KR, Patel A, Gadhiya NB. Risk factors for sputum positive pulmonary tuberculosis retreatment cases and factors responsible for treatment outcome. J Assoc Physicians India. 2019;67:56-8.
Torres A, Pilar RD. Factores de riesgo asociados a recaídas por tuberculosis pulmonar en pacientes atendidos en el hospital regional docente de Trujillo (tesis). Trujillo: Universidad Nacional de Trujillo; 2012. Fecha de consulta: 13 de octubre de 2019. Disponible en: http://dspace.unitru.edu.pe/handle/UNITRU/5493
Toledano Y, Assef S, Benítez E, Mulet E, Nápoles N. Recaída y factores de riesgo asociados en pacientes con tuberculosis en Santiago de Cuba (2002-2008). MEDISAN. 2010;14:1045-53.
Ampuero G, Pacheco A. Factores asociados a recaídas por tuberculosis en el Hospital Nacional Sergio E. Bernales 2016 (tesis). Lina: Universidad Nacional Mayor de San Marcos; 2016. Fecha de consulta: 13 de octubre de 2019. Disponible en: http://cybertesis.unmsm.edu.pe/bitstream/handle/cybertesis/6128/Ampuero_pg.pdf?sequence=1&isAllowed=y
San Martín A, Zapata E. Factores predisponentes en recaídas de tuberculosis de pacientes adultos con esquema I, Hospital Regional “Jamo” II-2 Tumbes, enero de 2008 a enero de 2014 (tesis). Trujillo: Universidad Privada Antenor Orrego; 2015. Fecha de consulta: 13 de octubre de 2019. Disponible en: http://repositorio.upao.edu.pe/handle/upaorep/3720
Muñoz P, Gili M, Calzada M, Ruiz L, Villanueva A, Salido A, et al. Índice de masa corporal y riesgo de tuberculosis pulmonar. Resultados de un estudio de casos y testigos. Archivos de Bronconeumología. 1991;27:166-70. https://doi.org/10.1016/S0300-2896(15)31507-6
Bhargava A, Benedetti A, Oxlade O, Pai M, Menzies D. Undernutrition and the incidence of tuberculosis in India: National and subnational estimates of the population- attributable fraction related to undernutrition. Natl Med J India. 2014;27:120-33.
Ministerio de la Protección Social. Circular 058 de 2009. Lineamientos para el manejo programático de la tuberculosis y lepra en Colombia. Bogotá: Ministerio de la Protección Social; 2009. Fecha de consulta: 13 de octubre de 2019. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/circular-058-2009.pdf
Kelsey. JL, Thompson WD, Evans AS. Methods in observational epidemiology. New York: Oxford University Press; 1986.
Thomas PR. Sample size determination and power. New Jersey: John Wiley & Sons, Inc.; 1982.
James J. Case-control studies: Design, conduct, analysis. New York: Oxford University Press; 1982.
Checkoway H, Pierce N, Douglas J. Research methods in occupational epidemiology. Monographs in Epidemiology and Biostatistics. Vol. 13. New York: Oxford University Press; 1989.
David G., Lawrence L, Morgenstern H. Epidemiologic Research: Principles and quantitative methods. New York: Van Nostrand Reinhold; 1982.
IBM Corp. SPSS, v. 26 package. Armonk: IBM Corp.; 2012.
Mitchell H. Mutivariable analysis: A practical guide for clinicians. Second edition. New York: Cambridge University Press; 2006.
Palta M. Quantitative methods in population health”extensions of ordinary regression. Hoboken: John Wiley & Sons; 2003.
Thomas A, Gopi PG, Santha T, Chandrasekaran V, Subramani R, Selvakumar N, et al. Predictors of relapse among pulmonary tuberculosis patients treated in a DOTS programme in South India. Int J Tuberc Lung Dis. 2005;9:556-61.
World Health Organization. Rio Political Declaration on Social Determinants of Health. Rio de Janeiro: WHO; 2011. Accessed: March 28, 2017. Available at: https://www.who.int/sdhconference/declaration/Rio_political_declaration.pdf?ua=1
Millet JP, Moreno A, Fina L, del Baño L, Orcau AA, de Olalla P, et al. Factors that influence current tuberculosis epidemiology. Eur Spine J. 2013;22:539-48. https://doi.org/10.1007/s00586-012-2334-8
Gadoev J, Asadov D, Harries A, Parpieva N, Tayler-Smith K, Isaakidis P, et al. Recurrent tuberculosis and associated factors: A five-year countrywide study in Uzbekistan. PLoS One. 2017;12:e0176473. https://doi.org/10.1371/journal.pone.0176473
Kim L, Moonan P, Heilig C, Yelk Woodruff R RS, Kammerer J, Haddad M. Factors associated with recurrent tuberculosis more than 12 months after treatment completion. Int J Tuberc Lung Dis. 2016;20:49-56. https://doi.org/10.5588/ijtld.15.0442
Núñez E. Factores asociados a recaídas por tuberculosis en el Hospital Nacional Guillermo Almenara Irigoyen (tesis). Lima: Universidad Nacional Federico Villarreal; 2018. Fecha de consulta: 13 de octubre de 2019. Disponible en: http://repositorio.unfv.edu.pe/handle/UNFV/1881
Mehdi M, Ruxana T. Patients at high risk of tuberculosis recurrence. Int J Mycobacteriol. 2018;7:1-6. https://doi.org/10.4103/ijmy.ijmy_164_17
Bestrashniy JR, Nguyen VN, Nguyen TL, Pham TL, Nguyen TA, Pham DC, et al. Recurrence of tuberculosis among patients following treatment completion in eight provinces of Vietnam: A nested case-control study. Int J Infect Dis. 2018;74:31-7. https://doi.org/10.1016/j.ijid.2018.06.013
Naidoo K, Dookie N. Insights into recurrent tuberculosis: Relapse versus reinfection and related risk factors. In: Ntumba Kayembe JM, editor. Tuberculosis. IntechOpen. 2018. https://doi.org/10.5772/intechopen.73601
Some similar items:
- Ana Yibby Forero Torres, Luis Carlos Forero, Comparison between anthropometric measurements and indices to evaluate general and abdominal obesity, Colombia ENSIN 2015 , Biomedica: Vol. 43 No. Sp. 3 (2023): Enfermedades crónicas no transmisibles
- Constanza Pardo, Ricardo Cendales, Survival analysis of cervical cancer patients , Biomedica: Vol. 29 No. 3 (2009)
- Raúl Murillo, Ricardo Cendales, Carolina Wiesner, Marion Piñeros, Sandra Tovar, Effectiveness of cytology-based cervical cancer screening in the Colombian health system , Biomedica: Vol. 29 No. 3 (2009)
- Sandra Lorena Girón, Julio César Mateus, Fabián Méndez, Impact of an open waste disposal site on the occurrence of respiratory symptoms and on health care costs of children , Biomedica: Vol. 29 No. 3 (2009)
- José Joaquín Carvajal, Ligia Inés Moncada, Mauricio Humberto Rodríguez, Ligia del Pilar Pérez, Víctor Alberto Olano, Characterization of Aedes albopictus (Skuse, 1894) (Diptera:Culicidae) larval habitats near the Amazon River in Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Andrés Páez, Gloria Rey, Carlos Agudelo, Alvaro Dulce, Edgar Parra, Hernando Díaz-Granados, Damaris Heredia, Luis Polo, Outbreak of urban rabies transmitted by dogs in Santa Marta, northern Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Patricia Escobar, Katherine Paola Luna, Indira Paola Hernández, César Mauricio Rueda, María Magdalena Zorro, Simon L. Croft, In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole , Biomedica: Vol. 29 No. 3 (2009)
- Gustavo Pradilla, Julio César Mantilla, Reynaldo Badillo, Human rabies encephalitis by a vampire bat bite in an urban area of Colombia , Biomedica: Vol. 29 No. 2 (2009)
- Mauricio Beltrán, María Cristina Navas, María Patricia Arbeláez, Jorge Donado, Sergio Jaramillo, Fernando De la Hoz, Cecilia Estrada, Lucía del Pilar Cortés, Amalia de Maldonado, Gloria Rey, Seroprevalence of hepatitis B virus and human immunodeficiency virus infection in a population of multiply-transfused patients in Colombia , Biomedica: Vol. 29 No. 2 (2009)
- Rosa Magdalena Uscátegui, Adriana M. Correa, Jaime Carmona-Fonseca, Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria , Biomedica: Vol. 29 No. 2 (2009)
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
