Neonatal late-onset infection with SARS CoV-2
Abstract
During the SARS COV-2 pandemic, the vast majority of infected patients are showing symptoms related to lung damage. At pediatric ages, especially newborns, symptoms from other organ systems without respiratory illness could make COVID-19 hard to diagnose.
We are reporting three cases of newborns who were attended in the course of the mitigation phase in the emergency service of a maternal hospital in Barranquilla, Colombia, for high temperature and general compromised condition. During their clinical course, they developed gastrointestinal symptoms without showing any respiratory manifestations.
They were not epidemiologically linked to a contact suspected to be a COVID-19 case and their mothers had had no respiratory symptoms since the public health emergency in our country was declared 45 days before. The absence of clinical respiratory manifestations in this group of patients with COVID-19 should draw clinicians’ attention to the need to suspect SARS CoV-2 infection in febrile newborns.
Downloads
References
de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: Recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14:523-34. https://doi.org/10.1038/nrmicro.2016.81
Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020. https://doi.org/10.1001/jamapediatrics.2020.0878
Coronado-Muñoz A, Nawaratne U, McMann D, Ellsworth M, Meliones J, Boukas K. Lateonset neonatal sepsis in a patient with Covid-19. N Engl J Med. 2020;382:e49. https://doi.org/10.1056/NEJMc2010614
Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020. https://doi.org/10.5858/arpa.2020-0901-SA
Wei M, Yuan J, Liu Y, Fu T, Yu X, Zhang ZJ. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323:1313-4. https://doi.org/10.1001/jama.2020.2131
Ministerio de Tecnologías de la Información y las Comunicaciones. Casos positivos de COVID-19 en Colombia | Datos Abiertos Colombia. Fecha de consulta: 14 de mayo de 2020. Disponible en: https://www.datos.gov.co/Salud-y-Protecci-n-Social/Casos-positivos-de-COVID-19-en-Colombia/gt2j-8ykr/data
Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects --Reviewing the evidence for causality. N Engl J Med. 2016;374:1981-7. https://doi.org/10.1056/NEJMsr1604338
Honein MA. Recognizing the global impact of Zika virus infection during pregnancy. N Engl J Med. 2018;378:1055-6. https://doi.org/10.1056/NEJMe1801398
Hosier H, Farhadian S, Morotti R, Deshmukh U, Lu-Culligan A, Campbell K, et al. SARS CoV-2 Infection of the placenta. medRxiv 2020. https://doi.org/10.1101/2020.04.30.20083907
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 2020;395:809-15. https://doi.org/10.1016/s0140-6736(20)30360-3
Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, Abbasi H, Mirjalili SR, Behforouz A, et al. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: A review. Fetal Pediatr Pathol. 2020:1-5. https://doi.org/10.1080/15513815.2020.1747120
Sutton D, Fuchs K, D’Alton M, Goffman D. Universal screening for SARS-CoV-2 in women admitted for delivery. N Engl J Med. 2020:382:2163-4 https://doi.org/10.1056/NEJMc2009316
Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203:631-7. https://doi.org/10.1002/path.1570
Tang A, Tong ZD, Wang HL, Dai YX, Li KF, Liu JN, et al. Detection of novel coronavirus by RT-PCR in stool specimen from asymptomatic child, China. Emerg Infect Dis. 2020;26:1337-9. https://doi.org/10.3201/eid2606.200301
Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARSCoV-2. Gastroenterology. 2020;158:1831-3. https://doi.org/10.1053/j.gastro.2020.02.055
Cai X, Ma Y, Li S, Chen Y, Rong Z, Li W. Clinical characteristics of 5 COVID-19 cases with non-respiratory symptoms as the first manifestation in children. Front Pediatr. 2020;8:258. https://doi.org/10.3389/fped.2020.00258
Xu Y, Li X, Zhu B, Liang H, Fang C, GongY, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26:502-5. https://doi.org/10.1038/s41591-020-0817-4
Yu Y, Chen P. Coronavirus disease 2019 (COVID-19) in neonates and children from China: A review. Front Pediatr. 2020;8:287. https://doi.org/10.3389/fped.2020.00287
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: Immunity, inflammation and intervention. Nat Rev Immunol. 2020;20:363-74. https://doi.org/10.1038/s41577-020-0311-8
Some similar items:
- Diego A. Álvarez-Díaz, Katherine Laiton-Donato, Carlos Franco-Muñoz, Marcela Mercado-Reyes, SARS-CoV-2 sequencing: The technological initiative to strengthen early warning systems for public health emergencies in Latin America and the Caribbean , Biomedica: Vol. 40 No. Supl. 2 (2020): SARS-CoV-2 y COVID-19
- Sergio Iván Agudelo, Carlos Federico Molina, Óscar Andrés Gamboa, Juan David Suárez, Direct costs of neonatal infection acquired in the community in full-term newborns and low risk at birth, Cundinamarca, Colombia , Biomedica: Vol. 41 No. 1 (2021)
- Francisco J. Díaz, Wbeimar Aguilar-Jiménez, Lizdany Flórez-Álvarez, Gladys Valencia, Katherine Laiton-Donato, Carlos Franco-Muñoz, Diego Álvarez-Díaz, Marcela Mercado-Reyes, María Teresa Rugeles, Isolation and characterization of an early SARS-CoV-2 isolate from the 2020 epidemic in Medellín, Colombia , Biomedica: Vol. 40 No. Supl. 2 (2020): SARS-CoV-2 y COVID-19
- Felipe Botero-Rodríguez, Oscar Franco, Carlos, Pandemic's glossary: The ABC of coronavirus concepts , Biomedica: Vol. 40 No. Supl. 2 (2020): SARS-CoV-2 y COVID-19
- José Moreno-Montoya, Epidemiology of self-care beyond the individual and the sanitary spheres , Biomedica: Vol. 40 No. Supl. 2 (2020): SARS-CoV-2 y COVID-19
- César Hernán Campo, María Fernanda Martínez, Juan Carlos Otero, Giovanna Rincón, Vagino-rectal colonization prevalence by Streptococcus agalactiae and its susceptibility profile in pregnant women attending a third-level hospital , Biomedica: Vol. 39 No. 4 (2019)
- Carolina Wiesner, Cancer research in the SARS-CoV pandemia , Biomedica: Vol. 40 No. 2 (2020)
- Lorena Peñaloza, Catalina Forero, Camila Céspedes, Characterization of patients diagnosed with congenital hypothyroidism at the Hospital Universitario San Ignacio between 2001 and 2017 , Biomedica: Vol. 40 No. 3 (2020)
- Alfredo G. Torres, Vaccines against SARS-CoV-2: Are they a reality for Latin America? , Biomedica: Vol. 40 No. 3 (2020)
- Luis Alberto Gómez, Editorial note about SARS-CoV-2 in the pandemic era , Biomedica: Vol. 40 No. Supl. 2 (2020): SARS-CoV-2 y COVID-19
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
