Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population

Luis Fernando Valladales-Restrepo , Juan Alberto Ospina-Cano , María José Londoño-Serna , Jorge Enrique Machado-Alba, .

Keywords: Sexually transmitted diseases, urethritis, recurrence, male, condoms, public health

Abstract

Introduction: Sexually transmitted infections are a public health problem worldwide. Their inadequate antimicrobial management has been associated with a higher risk of recurrence.
Objective: To characterize the main sexually transmitted infections, the adherence to clinical practice guidelines, and the factors associated with recurrence in Colombia.
Materials and methods: We conducted an observational study to identify the main sexually transmitted infections, the sociodemographic variables, and the pharmacological management in a patient cohort from a population database of 6.5 million people affiliated with the Colombian health system. We made a multivariate analysis to identify the variables associated with recurrence.
Results: We detected 3,158 patients with a mean age of 41.8 ± 14.5 years, of whom 63.1% were men. We found 4.030 episodes of sexually transmitted infections, predominantly urethral syndrome (27.5%). Only 13.6% of patients with urethral syndrome, ulcerative syndrome, or genital warts were managed in compliance with clinical practice guidelines and 20.6% were dispensed condoms; 16.7% of patients had recurrences and being male (OR=1.32; 95%CI 1.08-1.63), <30 years old (OR=1.72; 95%CI 1.40-2.13), being treated in municipalities other than capital cities (OR=1.43; 95%CI 1.06-1.94), and having received inadequate treatment for the first episode (OR=1.93; 95%CI 1.52-2.39) were associated with recurrence.
Conclusions: The majority of patients with sexually transmitted infections were not treated in compliance with clinical practice guidelines and those who did not have adequate management had a higher risk of recurrence.

Downloads

Download data is not yet available.
  • Luis Fernando Valladales-Restrepo Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Colombia; Grupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia https://orcid.org/0000-0002-4245-0101
  • Juan Alberto Ospina-Cano Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Colombia https://orcid.org/0000-0001-9043-8177
  • María José Londoño-Serna Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Colombia https://orcid.org/0000-0002-4503-8382
  • Jorge Enrique Machado-Alba Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Colombia https://orcid.org/0000-0002-8455-0936

References

Sexually Transmitted Diseases. Summary of 2015 CDC Treatment Guidelines. J Miss State Med Assoc. 2015;56:372-5.

American Sexual Health Association. STDs/STIs. Accessed on: June 1, 2020. Available from: http://www.ashasexualhealth.org/stdsstis/

Buder S, Schöfer H, Meyer T, Bremer V, Kohl PK, Skaletz-Rorowski A, et al. Bacterial sexually transmitted infections. J Dtsch Dermatol Ges. 2019;17:287-315. https://doi.org/10.1111/ddg.13804

Rowley J, Vander Hoorn S, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97:548-62. https://doi.org/10.2471/BLT.18.228486

de Amorim TF, Teles SA, Moraes LC, de Matos MA, Carneiro M, Nogueira DJ, et al. Symptomatic sexually transmitted infections in Brazil’s emerging rural populations. J Assoc Nurses AIDS Care. 2018;29:942-8. https://doi.org/10.1016/j.jana.2018.05.004

World Health Organization. Report on global sexually transmitted infection surveillance, 2018. Accessed on: June 1, 2020. Available from: https://www.who.int/reproductivehealth/publications/stis-surveillance-2018/en/

Korenromp EL, Ríos C, Apolinar ALS, Caicedo S, Cuéllar D, Cárdenas I, et al. Prevalence and incidence estimates for syphilis, chlamydia, gonorrhea, and congenital syphilis in Colombia, 1995-2016. Rev Panam Salud Pública. 2018;42:e118. https://doi.org/10.26633/RPSP.2018.118

Sieving RE, Gewirtz O’Brien JR, Saftner MA, Argo TA. Sexually transmitted diseases among us adolescents and young adults: Patterns, clinical considerations, and prevention. Nurs Clin North Am. 2019;54:207-25. https://doi.org/10.1016/j.cnur.2019.02.002

Tisler-Sala A, Ojavee SE, Uusküla A. Treatment of chlamydia and gonorrhoea, compliance with treatment guidelines and factors associated with non-compliant prescribing: Findings form a cross-sectional study. Sex Transm Infect. 2018;94:298-303. https://doi.org/10.1136/sextrans-2017-053247

Ministerio de Salud y Protección Social - Colciencias. Guía de práctica clínica para el abordaje sindrómico del diagnóstico y tratamiento de los pacientes con infecciones de transmisión sexual y otras infecciones del tracto genital, 2013. Accessed on: June 1, 2020. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/IETS/profesionales%20salud.pdf

Moreno-Ribera N, Fuertes-de Vega I, Blanco-Arévalo JL, Bosch-Mestres J, González-Cordón A, Estrach-Panella T, et al. Sexually transmitted infections: Experience in a multidisciplinary clinic in a tertiary hospital (2010-2013). Actas Dermosifiliogr. 2016;107:235-41. https://doi.org/10.1016/j.ad.2015.10.007

Jacob L, Duse DA, Kostev K. Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men. Ger Med Sci. 2018;16:1-7. https://doi.org/10.3205/000265

Boffin N, Moreels S, Deblonde J, van Casteren V. Four sexually transmitted infections (STIs) in Belgian general practice: First results (2013-2014) of a nationwide continuing surveillance study. BMJ Open. 2017;7:e012118. https://doi.org/10.1136/bmjopen-2016-012118

Wetten S, Mohammed H, Yung M, Mercer CH, Cassell JA, Hughes G. Diagnosis and treatment of chlamydia and gonorrhoea in general practice in England 2000-2011: A population-based study using data from the UK Clinical Practice Research Datalink. BMJ Open. 2015;5:e007776. https://doi.org/10.1136/bmjopen-2015-007776

Forster R, Ng D, Upton A, Franklin R, Thomas M. Treatment of gonorrhoea in Auckland, New Zealand: Marked variation in prescriber adherence to treatment guidelines. Intern Med J. 2017;47:640-8. https://doi.org/10.1111/imj.13433

Mohammed H, Sile B, Furegato M, Fifer H, Hughes G. Poor adherence to gonorrhoea treatment guidelines in general practice in England. Br J Gen Pract. 2016;66:352. https://doi.org/10.3399/bjgp16X686077

van Amerongen R, Gazendam RP, van Bergen JEAM. Trends in antimicrobial management of gonorrhoea by general practitioners in Amsterdam, the Netherlands, between 2010 and 2016: A cross-sectional study. BMC Fam Pract. 2019;20:12. https://doi.org/10.1186/s12875-018-0900-9

Almeida VC, Donalisio MR, Cordeiro R. Factors associated with reinfection of syphilis in reference centers for sexually transmitted infections. Rev Saúde Pública. 2017;51:64. https://doi.org/10.1590/S1518-8787.2017051006432

Généeux M, Leclerc P, Bédard L, Allard R. Upsurge of chlamydial reinfection in a large Canadian city: An indication of suboptimal Chlamydia screening practices? Can J Public Health. 2010;101:420-4. https://doi.org/10.1007/BF03404865

Amiri S, Pham CD, Amram O, Alcover KC, Oluwoye O, Bravo L, et al. Proximity to screening site, rurality, and neighborhood disadvantage: Treatment status among individuals with sexually transmitted infections in Yakima County, Washington. Int J Environ Res Public Health. 2020;17:2679. https://doi.org/10.3390/ijerph17082679

Panchanadeswaran S, Johnson SC, Mayer KH, Srikrishnan AK, Sivaran S, Zelaya CE, et al. Gender differences in the prevalence of sexually transmitted infections and genital symptoms in an urban setting in southern India. Sex Transm Infect. 2006;82:491-5. https://doi.org/10.1136/sti.2006.020768

Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC, et al. Sexually transmitted infections among US women and men: Prevalence and incidence estimates, 2008. Sex Transm Dis. 2013;40:187-93. https://doi.org/10.1097/OLQ.0b013e318286bb53

Sonnenberg P, Clifton S, Beddows S, Field N, Soldan K, Tanton C, et al. Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: Findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). Lancet. 2013;382:1795-806. https://doi.org/10.1016/S0140-6736(13)61947-9

Dolan G, Chauhan M, Foster K, Basta M, Bushby S, White C, et al. Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002-2014. Int J STD AIDS. 2018;29:790-99. https://doi.org/10.1177/0956462418757554

López-de-Munain J, Cámara-Pérez MD, Imaz-Pérez M, Pereda-Berroeta J, López-Azcarreta I, Muñoz-Sánchez J, et al. Chlamydia trachomatis re-infection in Spain: A STI clinic-based cohort study. Enferm Infecc Microbiol Clin. 2017;35:165-73. https://doi.org/10.1016/j.eimc.2016.08.011

How to Cite
1.
Valladales-Restrepo LF, Ospina-Cano JA, Londoño-Serna MJ, Machado-Alba JE. Characterization of sexually transmitted infections, their pharmacological treatment, and recurrence in a Colombian population. biomedica [Internet]. 2021 Oct. 15 [cited 2024 May 16];41(Sp. 2):130-9. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/5872

Some similar items:

Published
2021-10-15

Altmetric

Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views
Crossref Cited-by logo
QR Code