Exogenous pigmentation by silver nitrate: Dermatological and toxicological aspects, case report

Ángela Londoño, Camila Pérez, Rodrigo Restrepo, Nathalie Morales, Miguel Martínez, Daniela Morales, .

Keywords: Silver nitrate, argyria, melanoma, case reports, Colombia

Abstract

Exogenous pigmentation by silver nitrate is a rare disease whose clinical manifestations appear even years after the contact, making its diagnosis difficult on occasions. It is characterized by the presence of blue-gray macules or plaques on the skin or mucosa in the contact area, sometimes very similar to melanocytic lesions and melanoma, which constitute the main differential diagnosis.
We report the case of a male patient from Medellín, Colombia, with a family history of melanoma and the presence of these lesions throughout his body.

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References

Salvaneschi MB, Jaled M, Olivares L, Candiz ME, Maronna E. Argiria cutánea generalizada por aplicación prolongada de sulfadiazina de plata. Dermatología Argentina. 2017;23:89-91.

Hill WR, Pillsburg DM. Argyria; The pharmacology of silver. Baltimore: The Williams & Wilkins Company; 1939.

Jung I, Joo EJ, Suh BS, Ham CB, Han JM, Kim YG, et al. A case of generalized argyria presenting with muscle weakness. Ann Occup Environ Med. 2017;29:45. https://doi.org/10.1186/S40557-017-0201-0

Enei ML, Paschoal FM, Valdés R. Argyria mimicking a blue nevis: Dermoscopy features. An Bras Dermatol. 2013;88:452-5. https://doi.org/10.1590/Abd1806-4841.20132022

Okan D, Sibbald Rg. So what if you are blue? Oral colloidal silver and argyria are out: Safe dressings are in. Adv Skin Wound Care. 2007;20:326-30. https://doi.org/10.1097/01.Asw.0000276415.91750.0f

Drake PL, Hazelwood KJ. Exposure-related health effects of silver and silver compounds: A review. Ann Occup Hyg. 2005;49:575-85. https://doi.org/10.1093/annhyg/mei019

Fisher NM, Marsh E, Lazova R. Scar-localized argyria secondary to silver sulfadiazine cream. J Am Acad Dermatol. 2003;49:730-2. https://doi.org/10.1067/S0190-9622(02)61574-9

Glehr M, Leithner A, Friesenbichler J, Goessler W, Avian A, Andreou D, et al. Argyria following the use of silver-coated megaprostheses: No association between the development of local argyria and elevated silver levels. Bone Jt J. 2013;95-B:988-92. https://doi.org/10.1302/0301-620X.95B7.31124

Marshall JP, Schneider RP. Systemic argyria secondary to topical silver nitrate. Arch Dermatol. 1977;113:1077-9.

Macintire D, Mclay AL, East BW, Williams ED, Boddy K. Silver poisoning associated with an antismoking lozenge. Br Med J. 1978;2:1749-50. https://doi.org/10.1136/bmj.2.6154.1749-a

Park MY, Lee JS, Jin HJ, You HS, Kim GW, Ko HC, et al. Localized argyria: Troublesome side-effect of acupuncture. J Eur Acad Dermatol Venereol. 2018;32:e62-5. https://doi.org/10.1111/jdv.14526

Hadrup N, Lam HR. Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review. Regul Toxicol Pharmacol. 2014;68:1-7. https://doi.org/10.1016/j.yrtph.2013.11.002

Hadrup N, Sharma AK, Loeschner K. Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review. Regul Toxicol Pharmacol. 2018;98:257-67. https://doi.org/10.1016/j.yrtph.2018.08.007

Dempsey EW, Wislocki GB. The use of silver nitratre as a vital stain, and its distribution in several mammalian tissues as studied with the electron microscope J Biophys Biochem Cytol. 1955;1:111-8. https://doi.org/10.1083/jcb.1.2.111

Matuk Y, Ghosh M, McCulloch C. Distribution of silver in the eyes and plasma proteins of the albino rat. Can J Ophthalmol. 1981;16:145-50.

Furchner JE, Richmond CR, Drake GA. Comparative metabolism of radionuclides in mammals-IV. Retention of silver-110m in the mouse, rat, monkey, and dog. Health Phys. 1968;15:505-14. https://doi.org/10.1097/00004032-196812000-00005

Posada A. Pigmentación oscura del estrato córneo, ¿cuál es su diagnóstico? Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 2014;22:256-7.

McClain CM, Kantrow SM, Abraham JL, Price J, Parker ER, Robbins JB. Localized cutaneous argyria: Two case reports and clinicopathologic review. Am J Dermatopathol. 2013;35:e115-8. https://doi.org/10.1097/DAD.0b013e318284e37b

Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB. Myoclonic status epilepticus following repeated oral ingestion of colloidal silver. Neurology. 2004;62:1408-10. https://doi.org/10.1212/01.WNL.0000120671.73335.EC

García-Martínez P, López-Aventín D, Segura S, Gómez-Martín I, Lloreta J, Ibáñez J, et al. In vivo reflectance confocal microscopy characterization of silver deposits in localized cutaneous argyria. Br J Dermatol. 2016;175:1052-5. https://doi.org/10.1111/bjd.14571

Alghamdi SA, Zoroquiain P, Dias ABT, Alhumaid SR, Aldrees S, Burnier Jr MN. Diagnostic value of SOX-10 immunohistochemical staining for the detection of uveal melanoma. Ecancermedicalscience. 2015;9:566. https://doi.org/10.3332/ecancer.2015.566

Griffiths MR, Milne JT, Porter WM. Penile argyria. Br J Dermatol. 2006;155:1074-5. https://doi.org/10.1111/j.1365-2133.2006.07463.x

Liu J, Wang Z, Liu FD, Kane AB, Hurt RH. Chemical transformations of nanosilver in biological environments. ACS Nano. 2012;6:9887-99. https://doi.org/10.1021/nn303449n

Tajirian AL, Campbell RM, Robinson-Bostom L. Localized argyria after exposure to aerosolized solder. Cutis. 2006;78:305-8.

How to Cite
1.
Londoño Ángela, Pérez C, Restrepo R, Morales N, Martínez M, Morales D. Exogenous pigmentation by silver nitrate: Dermatological and toxicological aspects, case report. biomedica [Internet]. 2021 Jun. 29 [cited 2024 May 17];41(2):234-9. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/5876

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Published
2021-06-29
Section
Case presentation

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