Drug-resistant tuberculosis in Colombia, 2013-2018: Case-control study
Abstract
Introduction. Multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) is difficult to control, has high morbidity and mortality, and demands priority public health intervention. In Colombia, MDR/RR-TB has been becoming more widespread annually. Before the COVID-19 pandemic, over an 8-year period, the number of cases of multidrug-resistant tuberculosis in Colombia was close to a thousand cases. Timely identification of the different risk factors for MDR/RR-TB will contribute fundamentally to the systematic management.
Objective. To determine which risk factors were associated with the presentation of MDR in Colombia between 2013 and 2018.
Materials and methods. A retrospective case-control study was carried out, for which the data from the routine surveillance of MDR/events in the country were used.
Results. The cases of multidrug-resistant tuberculosis were mainly in young people, Afrodescendants, and males. Of the clinical conditions, comorbidities such as malnutrition, diabetes, and HIV, presence of at least one factor, such as drug dependence, taking immunosuppressive medications, belonging to the black race, afro, and living in an area of high disease burden were risk factors.
Conclusion. In addition to the diagnosis and timely provision of MDR-TB treatment, it is necessary that public health programs at the local level pay special attention to patients with the identified risk factors.
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References
World Health Organization. Tuberculosis. Accessed: August 30, 2023. Available from: https://www.who.int/es/news-room/fact-sheets/detail/tuberculosis
World Health Organization. Global Tuberculosis Report 2021. Accessed: August 30, 2023. Available from: https://www.who.int/publications/i/item/9789240037021
World Health Organization. Global Tuberculosis report 2020. Accessed: August 30, 2023. Available from: https://www.who.int/publications/i/item/9789240013131
Instituto Nacional de Salud. Informe de evento. Tuberculosis farmacorresistente, Colombia, 2020. Accessed: August 30, 2023. Available from: http://www.ins.gov.co/buscador-eventos/Informesdeevento/TUBERCULOSIS%20FARMACORRESISTENTE_2020.pdf
Seung KJ, Keshavjee S, Rich ML. Multidrug-resistant tuberculosis and extensively drugresistant tuberculosis. Cold Spring Harb Perspect Med. 2015;7:1-20. https://doi.org/10.1101/cshperspect.a017863
World Health Organization. Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis. Geneva: WHO; 2014. p. 1–452.
Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública, Tuberculosis farmacorresistente, código 813. Accessed: June 24, 2023. Available from: https://www.ins.gov.co/buscador-eventos/Lineamientos/PRO_Tuberculosis_farmacorresistente.pdf
Instituto Nacional de Salud. Ficha de notificación individual – Datos complementarios. Tuberculosis Cod INS 813. Accessed: June 24, 2023. Available from: https://www.ins.gov.co/buscador-eventos/Lineamientos/813%20Tuberculosis%202023.pdf
Lazcano E, Salazar E, Hernández M. Estudios epidemiológicos de casos y controles. Fundamento teórico, variantes y aplicaciones. Salud Pública Méx. 2001;43:135-50.
Martínez MÁ, Sánchez A, Faulin FJ. Introducción a los modelos multivariables. In: Díaz de Santos SA, editor. Bioestadística amigable. Segunda edición. Madrid: Universidad de Navarra; 2006.
Ministerio de Salud y Protección Social. Resolución 227 de 2020. Lineamientos técnicos y operativos del programa nacional de prevención y control de la tuberculosis. Accessed: August 30, 2023. Available from: https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%C3%B3n%20No.%20227%20de%202020.pdf
Ministerio de Salud y Protección Social. Plan estratégico “Hacia el fin de la Tuberculosis”. Colombia 2016-2025. Accessed: August 30, 2023. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/INTOR/Plan-estrategico-fin-tuberculosiscolombia-2016-2025.pdf
Ferro BE, Nieto LM, Rozo JC, Forero L, van Soolingen D. Multidrug-resistant Mycobacterium tuberculosis, southwestern Colombia. Emerg Infect Dis. 2011;17:1259–62. https://doi.org/10.3201/eid1707.101797
Baya B, Achenbach CJ, Kone B, Toloba Y, Dabitao DK, Diarra B, et al. Clinical risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Mali. Int J Infect Dis. 2019;81:149-55. https://doi.org/10.1016/j.ijid.2019.02.004
Rifat M, Milton AH, Hall J, Oldmeadow C, Islam MA, Husain A, et al. Development of multidrug resistant tuberculosis in Bangladesh: A case-control study on risk factors. PLoS One. 2014;9:e105214. https://doi.org/10.1371/journal.pone.0105214
van den Hof S, Collins D, Hafidz F, Beyene D, Tursynbayeva A, Tiemersma E. The socioeconomic impact of multidrug resistant tuberculosis on patients: Results from Ethiopia, Indonesia and Kazakhstan. BMC Infect Dis. 2016;16:470-83. https://doi.org/10.1186/s12879-016-1802-x
He XC, Zhang XX, Zhao JN, Liu Y, Yu CB, Yang GR, et al. Epidemiological trends of drugresistant tuberculosis in China from 2007 to 2014. Medicine (Baltimore). 2016;95:15-22. https://doi.org/10.1097/md.0000000000003336
Ali MH, Alrasheedy AA, Hassali MA, Kibuule D, Godman B. Predictors of multidrug-resistant tuberculosis (MDR-TB) in Sudan. Antibiotics (Basel). 2019;8:90-100. https://doi.org/10.3390/antibiotics8030090
Elduma AH, Mansournia MA, Foroushani AR, Ali HMH, Elegail AMA, Elsony A, et al. Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: A case-control study. Epidemiol Health. 2019;41:1-9. https://doi.org/10.4178/epih.e2019014
Congreso de la República de Colombia. Ley número 1122 de 2007. Accessed: June 24, 2023. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/ley-1122-de-2007.pdf
Departamento Administrativo Nacional de Estadística - DANE. Boletín Técnico, Medición de empleo informal y seguridad social, Trimestre abril - junio 2021 Accessed: June 24, 2023. Available from: https://www.dane.gov.co/files/investigaciones/boletines/ech/ech_informalidad/bol_geih_informalidad_abr21_jun21.pdf
Ministerio de Salud y Protección Social. Política de atención integral en salud “un sistema de salud al servicio de la gente. Accessed: June 24, 2023. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/modelo-pais-2016.pdf
Organización Mundial de la Salud. La COVID-19 pone de relieve la necesidad urgente de reactivar los esfuerzos mundiales por acabar con la tuberculosis. Accessed: June 24, 2023. Available from: https://www.who.int/es/news/item/22-03-2021-covid-19-highlights-urgentneed-to-reboot-global-effort-to-end-tuberculosis
Mesfin EA, Beyene D, Tesfaye A, Admasu A, Addise D, Amare M, et al. Drug-resistance patterns of Mycobacterium tuberculosis strains and associated risk factors among multi drug-resistant tuberculosis suspected patients from Ethiopia. PLoS One. 2018;13:e0197737. https://doi.org/10.1371/journal.pone.0197737
Lönnroth K, Williams BG, Cegielski P, Dye C. A consistent log-linear relationship between tuberculosis incidence and body mass index. Int J Epidemiol. 2010;39:149-55. https://doi.org/10.1093/ije/dyp308
Tegegne BS, Mengesha MM, Teferra AA, Awoke MA, Habtewold TD. Association between diabetes mellitus and multi-drug-resistant tuberculosis: Evidence from a systematic review and meta-analysis. Syst Rev. 2018;7:161-74. https://doi.org/10.1186/s13643-018-0828-0
Gómez-Gómez A, Magaña-Aquino M, López-Meza S, Aranda-Álvarez M, Díaz-Ornelas DE, Hernández-Segura MG, et al. Diabetes and other risk factors for multi-drug resistant tuberculosis in a Mexican population with pulmonary tuberculosis: Case control study. Arch Med Res. 2015;46:142–8. https://doi.org/10.1016/j.arcmed.2015.01.006
Organización Mundial de la Salud. Diabetes, Colombia 2016, perfil de país. Accessed: February 7, 2023. Available from: https://www.who.int/es/publications/m/item/diabetes-colcountry-profile-colombia-2016
Organización Mundial de la Salud. Diabetes, México 2016, perfil de país. Accessed: August 30, 2023. Available from: https://www.who.int/es/publications/m/item/diabetes-mex-countryprofile-mexico-2016
Caminero JA. Multidrug-resistant tuberculosis: Epidemiology, risk factors and case finding. Int J Tuberc Lung Dis. 2010;14:382-90.
Bergonzoli G, Castellanos LG, Rodríguez R, García LM. Determinants of tuberculosis in countries of Latin America and the Caribbean. Rev Panam Salud Pública. 2016;39:101-5.
Sultana ZZ, Hoque FU, Beyene J, Akhlak-Ul-Islam M, Khan MHR, Ahmed S, et al. HIV infection and multidrug resistant tuberculosis: A systematic review and meta-analysis. BMC Infect Dis. 2021;21:51-64. https://doi.org/10.1186/s12879-020-05749-2
Faustini A, Hall AJ, Perucci CA. Risk factors for multidrug resistant tuberculosis in Europe: A systematic review. Thorax. 2006;61:158-163. https://doi.org/10.1136/thx.2005.045963
Departamento Administrativo Nacional de Estadística - DANE. Estadísticas Demografía y Población - Grupos étnicos - Información técnica. Accessed: August 30, 2023. Available from: http://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/grupos-etnicos/informacion-tecnica
Departamento Administrativo Nacional de Estadística - DANE. Encuesta nacional de calidad de vida (ECV) 2018. Accessed: August 30, 2023. Available from: https://www.dane.gov.co/index.php/estadisticas-por-tema/salud/calidad-de-vida-ecv/encuesta-nacional-de-calidadde-vida-ecv-2018
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